Machine Learning Reduced Gene/Non-Coding RNA Features That Classify Schizophrenia Patients Accurately and Highlight Insightful Gene Clusters.
Algorithms
Biomarkers
/ metabolism
Computational Biology
/ methods
Diagnosis, Computer-Assisted
Factor Analysis, Statistical
Humans
Machine Learning
Multigene Family
Prefrontal Cortex
/ metabolism
RNA, Long Noncoding
/ genetics
RNA, Messenger
/ genetics
RNA, Untranslated
/ genetics
RNA-Seq
Schizophrenia
/ diagnosis
Transcriptome
long non-coding RNAs
machine learning
schizophrenia
transcriptome
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Mar 2021
25 Mar 2021
Historique:
received:
03
03
2021
revised:
20
03
2021
accepted:
23
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
12
6
2021
Statut:
epublish
Résumé
RNA-seq has been a powerful method to detect the differentially expressed genes/long non-coding RNAs (lncRNAs) in schizophrenia (SCZ) patients; however, due to overfitting problems differentially expressed targets (DETs) cannot be used properly as biomarkers. This study used machine learning to reduce gene/non-coding RNA features. Dorsolateral prefrontal cortex (dlpfc) RNA-seq data from 254 individuals was obtained from the CommonMind consortium. The average predictive accuracy for SCZ patients was 67% based on coding genes, and 96% based on long non-coding RNAs (lncRNAs). Machine learning is a powerful algorithm to reduce functional biomarkers in SCZ patients. The lncRNAs capture the characteristics of SCZ tissue more accurately than mRNA as the former regulate every level of gene expression, not limited to mRNA levels.
Identifiants
pubmed: 33805976
pii: ijms22073364
doi: 10.3390/ijms22073364
pmc: PMC8037538
pii:
doi:
Substances chimiques
Biomarkers
0
RNA, Long Noncoding
0
RNA, Messenger
0
RNA, Untranslated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : R37 MH057881
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH075916
Pays : United States
Organisme : The study and the APC were supported by Institutional Development Funds from the Children's Hospital of Philadel-phia to the Center for Applied Genomics, The Children's Hospital of Philadelphia Endowed Chair in Genomic Research to HH.
ID : na
Organisme : NIMH NIH HHS
ID : P50 MH084053
Pays : United States
Organisme : NIDA NIH HHS
ID : HHSN271201300031C
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH066392
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH080405
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085542
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH097276
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG002219
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH093725
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005138
Pays : United States
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