Role of the ROS-JNK Signaling Pathway in Hypoxia-Induced Atrial Fibrotic Responses in HL-1 Cardiomyocytes.
atrial fibrillation
fibrosis
hypoxia
signal transduction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Mar 2021
23 Mar 2021
Historique:
received:
13
02
2021
revised:
11
03
2021
accepted:
18
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
11
5
2021
Statut:
epublish
Résumé
By promoting atrial structural remodeling, atrial hypoxia contributes to the development of the atrial fibrillation substrate. Our study aimed to investigate the modulatory effect of hypoxia on profibrotic activity in cultured HL-1 cardiomyocytes and explore the possible signaling transduction mechanisms of profibrotic activity in vitro. Hypoxia (1% O
Identifiants
pubmed: 33806765
pii: ijms22063249
doi: 10.3390/ijms22063249
pmc: PMC8004875
pii:
doi:
Substances chimiques
Biomarkers
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Council
ID : National Science Council (NSC) (NSC-101-2314-B-040-018-MY3), Taiwan, R.O.C.
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