The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health.
Clostridium perfringens
RiPP
Ruminococcus gnavus E1
antibiotics
antimicrobial resistance
microbiome
peritonitis infection
sactipeptide
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Mar 2021
23 Mar 2021
Historique:
received:
23
02
2021
revised:
11
03
2021
accepted:
18
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
11
5
2021
Statut:
epublish
Résumé
The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized and post-translationally modified peptides (RiPPs). Interestingly, the highly potent in vitro antibacterial activity and safety of ruminococcin C1, a recently discovered RiPP belonging to the sactipeptide subclass, has been demonstrated. The present results show that ruminococcin C1 is efficient at curing infection and at protecting challenged mice from
Identifiants
pubmed: 33806791
pii: ijms22063253
doi: 10.3390/ijms22063253
pmc: PMC8005207
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Bacteriocins
0
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-15-CE21-0020
Organisme : Agence Nationale de la Recherche
ID : ANR-20-CE44-0021
Organisme : Agence Nationale de la Recherche
ID : ANR-10-INBS-08
Organisme : LABoratoires d'EXcellence ARCANE
ID : ANR-17-EURE-0003
Organisme : Association Nationale de la Recherche et de la Technologie
ID : 2016/0657
Références
Mucosal Immunol. 2017 Jan;10(1):18-26
pubmed: 27554295
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9352-7
pubmed: 20435915
Trends Microbiol. 2019 Apr;27(4):323-338
pubmed: 30683453
Nat Rev Drug Discov. 2013 May;12(5):371-87
pubmed: 23629505
Pharmaceutics. 2019 Jul 10;11(7):
pubmed: 31295834
J Clin Med. 2018 Apr 10;7(4):
pubmed: 29642570
Gut Pathog. 2013 Aug 13;5(1):23
pubmed: 23941657
Molecules. 2017 Oct 18;22(10):
pubmed: 29057807
Curr Opin Immunol. 2001 Feb;13(1):104-8
pubmed: 11154925
Mol Plant Pathol. 2005 Jul 1;6(4):395-409
pubmed: 20565666
Adv Nutr. 2018 Jan 1;9(1):21-29
pubmed: 29438462
Vet Microbiol. 2006 Mar 10;113(1-2):143-52
pubmed: 16337097
Front Cell Infect Microbiol. 2015 Jan 13;4:194
pubmed: 25629011
J Antimicrob Chemother. 2007 Feb;59(2):297-300
pubmed: 17213266
Appl Environ Microbiol. 1993 Sep;59(9):2876-83
pubmed: 8215361
Eur J Med Chem. 2018 Mar 25;148:306-313
pubmed: 29471119
Int J Biochem Cell Biol. 2010 Apr;42(4):506-18
pubmed: 19837184
Anal Biochem. 2020 Jan 1;588:113468
pubmed: 31585097
Nat Prod Rep. 2013 Jan;30(1):108-60
pubmed: 23165928
J Anim Sci. 2015 May;93(5):2363-74
pubmed: 26020332
Int J Microbiol. 2019 Jul 1;2019:7395127
pubmed: 31354831
Int J Syst Bacteriol. 1994 Oct;44(4):812-26
pubmed: 7981107
Exp Dermatol. 2016 Mar;25(3):167-73
pubmed: 26738772
Obesity (Silver Spring). 2010 Jan;18(1):190-5
pubmed: 19498350
mBio. 2018 Jul 24;9(4):
pubmed: 30042197
Infect Drug Resist. 2018 Oct 10;11:1645-1658
pubmed: 30349322
Front Cell Infect Microbiol. 2019 Apr 24;9:99
pubmed: 31069173
Molecules. 2019 Apr 18;24(8):
pubmed: 31003555
Front Microbiol. 2010 Dec 08;1:134
pubmed: 21687759
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4639-44
pubmed: 20616009
Expert Opin Investig Drugs. 2008 Mar;17(3):297-302
pubmed: 18321229
J Anim Sci Biotechnol. 2020 Feb 20;11:24
pubmed: 32099648
Sci Adv. 2019 Sep 25;5(9):eaaw9969
pubmed: 31579822
Annu Rev Phytopathol. 2013;51:39-59
pubmed: 23642002
Arch Tierernahr. 1994;46(1):37-50
pubmed: 7733811
Int J Syst Evol Microbiol. 2017 Oct;67(10):4146-4153
pubmed: 28905695
Microorganisms. 2019 Aug 19;7(8):
pubmed: 31430948
Biochimie. 2011 Sep;93(9):1487-94
pubmed: 21586310
F1000Res. 2017 Jan 17;6:51
pubmed: 28163908
Front Microbiol. 2019 Aug 07;10:1676
pubmed: 31447793
Microbiology (Reading). 2014 Feb;160(Pt 2):439-445
pubmed: 24287693
J Immunol Res. 2019 Dec 1;2019:7247238
pubmed: 31886308
P T. 2015 Apr;40(4):277-83
pubmed: 25859123
PLoS Biol. 2017 Aug 23;15(8):e2003775
pubmed: 28832581
J Clin Microbiol. 1999 Jun;37(6):1771-6
pubmed: 10325322
Biochem Pharmacol. 2017 Jun 1;133:4-19
pubmed: 27720719
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19168-19177
pubmed: 32719135
Infect Drug Resist. 2019 Dec 20;12:3903-3910
pubmed: 31908502
Int J Syst Evol Microbiol. 2010 Apr;60(Pt 4):845-849
pubmed: 19661493