Liquid Biopsy Biomarkers in Urine: A Route towards Molecular Diagnosis and Personalized Medicine of Bladder Cancer.
bladder cancer
free nucleic acids
liquid biopsy
urinary biomarkers
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
23 Mar 2021
23 Mar 2021
Historique:
received:
28
01
2021
revised:
10
03
2021
accepted:
19
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Bladder cancer (BC) is characterized by high incidence and recurrence rates together with genomic instability and elevated mutation degree. Currently, cystoscopy combined with cytology is routinely used for diagnosis, prognosis and disease surveillance. Such an approach is often associated with several side effects, discomfort for the patient and high economic burden. Thus, there is an essential demand of non-invasive, sensitive, fast and inexpensive biomarkers for clinical management of BC patients. In this context, liquid biopsy represents a very promising tool that has been widely investigated over the last decade. Liquid biopsy will likely be at the basis of patient selection for precision medicine, both in terms of treatment choice and real-time monitoring of therapeutic effects. Several different urinary biomarkers have been proposed for liquid biopsy in BC, including DNA methylation and mutations, protein-based assays, non-coding RNAs and mRNA signatures. In this review, we summarized the state of the art on different available tests concerning their potential clinical applications for BC detection, prognosis, surveillance and response to therapy.
Identifiants
pubmed: 33806972
pii: jpm11030237
doi: 10.3390/jpm11030237
pmc: PMC8004687
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Pediatr Pulmonol. 2012 Sep;47(9):856-63
pubmed: 22431382
BMC Med Res Methodol. 2015 May 12;15:45
pubmed: 25962444
J Transl Med. 2016 Oct 7;14(1):287
pubmed: 27717367
BJU Int. 2019 Jun;123(6):959-967
pubmed: 30653818
EBioMedicine. 2020 Mar;53:102643
pubmed: 32081602
Cancer Cytopathol. 2020 May;128(5):341-347
pubmed: 31977131
J Urol. 2018 Feb;199(2):401-406
pubmed: 28847481
J Urol. 2016 Mar;195(3):601-7
pubmed: 26327355
Eur Urol. 2017 Mar;71(3):447-461
pubmed: 27324428
Diagn Cytopathol. 2020 Nov;48(11):1034-1040
pubmed: 32562513
Oncotarget. 2016 Apr 12;7(15):20636-54
pubmed: 26943042
World J Urol. 2018 Dec;36(12):1981-1995
pubmed: 29931526
J Clin Pathol. 2019 Feb;72(2):140-144
pubmed: 30355587
Transl Res. 2017 Jun;184:108-117
pubmed: 28438520
Ann N Y Acad Sci. 2006 Sep;1075:334-40
pubmed: 17108229
Front Oncol. 2020 May 19;10:755
pubmed: 32509577
Eur Urol Oncol. 2018 Sep;1(4):307-313
pubmed: 31100252
J Urol. 2020 Oct;204(4):685-690
pubmed: 32314931
Nature. 2013 May 2;497(7447):108-12
pubmed: 23563269
Urol Oncol. 2010 Nov-Dec;28(6):655-61
pubmed: 19375957
J Urol. 2001 Apr;165(4):1067-77
pubmed: 11257640
BMC Cancer. 2016 Sep 01;16:704
pubmed: 27586786
Am J Pathol. 2001 Jun;158(6):1955-9
pubmed: 11395371
J Thorac Dis. 2017 Oct;9(Suppl 13):S1323-S1331
pubmed: 29184671
Clin Cancer Res. 2008 Feb 1;14(3):742-9
pubmed: 18245534
Diagnostics (Basel). 2020 Sep 24;10(10):
pubmed: 32987933
J Clin Oncol. 2016 Jun 20;34(18):2165-71
pubmed: 27044931
Nat Rev Clin Oncol. 2013 Aug;10(8):472-84
pubmed: 23836314
J Urol. 2017 Mar;197(3 Pt 1):590-595
pubmed: 27746284
J Urol. 1996 Oct;156(4):1280-5
pubmed: 8808854
Tumour Biol. 2015 Dec;36(12):9545-52
pubmed: 26138586
Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2786-94
pubmed: 18843024
J Clin Oncol. 2006 Aug 1;24(22):3664-71
pubmed: 16877735
Nat Rev Urol. 2020 May;17(5):259-270
pubmed: 32235944
BJU Int. 2018 Jan;121(1):29-37
pubmed: 28941000
World J Urol. 2012 Dec;30(6):869-73
pubmed: 22932760
Mod Pathol. 2019 Oct;32(10):1544-1550
pubmed: 31028363
J Urol. 2018 Mar;199(3):655-662
pubmed: 29061538
J Urol. 2007 Dec;178(6):2314-30
pubmed: 17993339
Tumour Biol. 2014 Nov;35(11):11435-42
pubmed: 25123267
Eur Urol. 2019 May;75(5):853-860
pubmed: 30553612
Clin Cancer Res. 2006 Aug 15;12(16):4851-8
pubmed: 16914571
Eur Urol Oncol. 2021 Feb;4(1):93-101
pubmed: 33004290
Cancer Sci. 2019 Oct;110(10):3235-3243
pubmed: 31368627
Nat Rev Nephrol. 2015 Apr;11(4):221-32
pubmed: 25643662
Cancer Discov. 2019 Apr;9(4):500-509
pubmed: 30578357
Cancer Commun (Lond). 2021 Feb;41(2):91-108
pubmed: 33377623
Cancer Manag Res. 2018 Nov 26;10:6357-6365
pubmed: 30568497
Urol Oncol. 2007 Jul-Aug;25(4):344-7
pubmed: 17628306
Front Cell Infect Microbiol. 2018 May 31;8:167
pubmed: 29904624
Adv Anat Pathol. 2008 Sep;15(5):279-86
pubmed: 18724101
Rev Urol. 2008 Spring;10(2):120-35
pubmed: 18660854
Genes (Basel). 2016 Dec 14;7(12):
pubmed: 27983635
Cancers (Basel). 2019 Dec 29;12(1):
pubmed: 31905736
Cancer Cytopathol. 2013 Oct;121(10):591-7
pubmed: 23801650
Clin Chem. 1999 Apr;45(4):472-7
pubmed: 10102906
Urol Oncol. 2008 Nov-Dec;26(6):646-51
pubmed: 18367109
Virus Res. 2014 Jun 24;186:20-31
pubmed: 24361981
Nat Genet. 1999 Sep;23(1):18-20
pubmed: 10471491
Theranostics. 2017 Jun 25;7(10):2606-2619
pubmed: 28819450
Pract Lab Med. 2020 Nov 13;22:e00189
pubmed: 33294574
Annu Rev Biochem. 1999;68:649-86
pubmed: 10872463
Eur Urol. 2013 Feb;63(2):234-41
pubmed: 22877502
Sci Rep. 2019 May 21;9(1):7635
pubmed: 31114012
Bladder Cancer. 2016 Jul 27;2(3):301-317
pubmed: 27500198
Lancet. 1999 Oct 30;354(9189):1524-5
pubmed: 10551502
Nat Rev Urol. 2019 Aug;16(8):484-504
pubmed: 31110275
Sci Transl Med. 2017 Aug 16;9(403):
pubmed: 28814544
Urol Oncol. 2017 Aug;35(8):531.e15-531.e22
pubmed: 28366272
CA Cancer J Clin. 2014 Sep-Oct;64(5):311-36
pubmed: 25104502
Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1483-91
pubmed: 21586619
Clin Chim Acta. 2000 Jul;297(1-2):55-66
pubmed: 10841908
J Urol. 2012 Sep;188(3):741-7
pubmed: 22818138
Cancer Epidemiol Biomarkers Prev. 2019 Jun;28(6):1036-1044
pubmed: 30593457
Cancer Res. 2013 Dec 15;73(24):7162-7
pubmed: 24121487
Int J Mol Sci. 2020 Sep 08;21(18):
pubmed: 32911596
J Urol. 2001 Jul;166(1):75-8
pubmed: 11435827
Tumour Biol. 2017 Jun;39(6):1010428317709990
pubmed: 28639914
J Natl Cancer Inst. 2002 Jul 17;94(14):1071-9
pubmed: 12122098
Transl Androl Urol. 2019 Dec;8(Suppl 5):S546-S549
pubmed: 32042643
Cancer Treat Rev. 2018 Nov;70:1-8
pubmed: 30053724
World J Urol. 2020 Sep;38(9):2215-2220
pubmed: 31691083
Mod Pathol. 2015 Apr;28(4):515-22
pubmed: 25394776
J Urol. 2017 Jun;197(6):1419-1426
pubmed: 27986532
BMC Urol. 2020 Feb 11;20(1):12
pubmed: 32046687
Cancer Cytopathol. 2019 Jul;127(7):465-469
pubmed: 31154670
Eur Urol. 2019 Jan;75(1):18-22
pubmed: 30266310
Clin Cancer Res. 2010 May 1;16(9):2624-33
pubmed: 20406841
Eur J Hum Genet. 2016 Aug;24(8):1167-74
pubmed: 26757983
Int J Mol Sci. 2018 Aug 24;19(9):
pubmed: 30149597
Eur Urol. 2021 Jan;79(1):62-79
pubmed: 32593530
Med Oncol. 2020 Nov 20;37(12):118
pubmed: 33216248
EBioMedicine. 2019 Jun;44:431-438
pubmed: 31122840
Front Oncol. 2019 Nov 19;9:1266
pubmed: 31803629
Chronic Obstr Pulm Dis. 2016 Mar 1;3(2):560-569
pubmed: 28848880
Health Technol Assess. 2010 Jan;14(4):1-331, iii-iv
pubmed: 20082749
BMC Med Genet. 2020 May 24;21(1):112
pubmed: 32448160
J Urol. 2017 Jun;197(6):1410-1418
pubmed: 28049011
Urol Oncol. 2021 Jan 9;:
pubmed: 33436328
Urology. 2015 Dec;86(6):1185-90
pubmed: 26364695
BJU Int. 2009 Aug;104(3):336-9
pubmed: 19220253
Clin Cancer Res. 2016 Aug 15;22(16):4077-86
pubmed: 27026199
Immunology. 2005 May;115(1):55-62
pubmed: 15819697
Int J Cancer. 2015 Oct 1;137(7):1621-9
pubmed: 25809917
J Cell Sci. 2001 Jun;114(Pt 11):2027-41
pubmed: 11493639
J Urol. 1995 Aug;154(2 Pt 1):379-83; discussion 383-4
pubmed: 7609102
Eur Urol. 2012 Jan;61(1):128-45
pubmed: 22000498
Cancers (Basel). 2020 Nov 27;12(12):
pubmed: 33260905
Urol Oncol. 2016 Apr;34(4):165.e19-23
pubmed: 26687318
Int J Cancer. 2009 Jun 15;124(12):2899-904
pubmed: 19230026
World J Urol. 2007 Dec;25(6):581-93
pubmed: 17912529
Eur Urol Oncol. 2020 Feb;3(1):42-46
pubmed: 31307961
Nat Biotechnol. 2007 Oct;25(10):1165-70
pubmed: 17891134
Clin Cancer Res. 1998 Oct;4(10):2511-20
pubmed: 9796985
Genes (Basel). 2017 Feb 17;8(2):
pubmed: 28218662
Int J Mol Sci. 2017 Jul 13;18(7):
pubmed: 28703782
Eur Urol. 2016 Feb;69(2):197-200
pubmed: 26119560
Pharmacoeconomics. 2014 Nov;32(11):1093-104
pubmed: 25056838
Sci Rep. 2017 Mar 24;7(1):395
pubmed: 28341852
PLoS One. 2012;7(7):e40305
pubmed: 22792272