miRNA Expression Characterizes Histological Subtypes and Metastasis in Penile Squamous Cell Carcinoma.
HPV
PSCC
miRNA
microarray
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Mar 2021
23 Mar 2021
Historique:
received:
02
02
2021
revised:
12
03
2021
accepted:
18
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Although microRNAs are described as promising biomarkers in many tumor types, little is known about their role in PSCC. Thus, we attempted to identify miRNAs involved in tumor development and metastasis in distinct histological subtypes considering the impact of HPV infection. In a first step, microarray analyses were performed on RNA from formalin-fixed, paraffin-embedded tumor (22), and normal (8) tissue samples. Microarray data were validated for selected miRNAs by qRT-PCR on an enlarged cohort, including 27 tumor and 18 normal tissues. We found 876 significantly differentially expressed miRNAs (
Identifiants
pubmed: 33807023
pii: cancers13061480
doi: 10.3390/cancers13061480
pmc: PMC8004785
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Universität des Saarlandes
ID : HOMFOR
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