Molecular Signatures of Natural Killer Cells in CMV-Associated Anterior Uveitis, A New Type of CMV-Induced Disease in Immunocompetent Individuals.
Adult
Aged
Aged, 80 and over
CD57 Antigens
/ genetics
Cohort Studies
Cytomegalovirus
/ immunology
Cytomegalovirus Infections
/ immunology
Female
Genes, MHC Class I
/ genetics
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Immunocompromised Host
/ immunology
Killer Cells, Natural
/ immunology
Lectins, C-Type
/ genetics
Male
Middle Aged
NK Cell Lectin-Like Receptor Subfamily C
/ genetics
Receptors, Immunologic
/ genetics
Receptors, KIR
/ genetics
Transplantation, Homologous
/ adverse effects
Uveitis, Anterior
/ genetics
CD57
HLA class I
KLRG1
NKG2C
cytomegalovirus
cytomegalovirus-associated anterior uveitis
killer cell immunoglobulin-like receptors
natural killer cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Mar 2021
31 Mar 2021
Historique:
received:
28
02
2021
revised:
29
03
2021
accepted:
29
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
14
5
2021
Statut:
epublish
Résumé
Cytomegalovirus (CMV) causes clinical issues primarily in immune-suppressed conditions. CMV-associated anterior uveitis (CMV-AU) is a notable new disease entity manifesting recurrent ocular inflammation in immunocompetent individuals. As patient demographics indicated contributions from genetic background and immunosenescence as possible underlying pathological mechanisms, we analyzed the immunogenetics of the cohort in conjunction with cell phenotypes to identify molecular signatures of CMV-AU. Among the immune cell types, natural killer (NK) cells are main responders against CMV. Therefore, we first characterized variants of polymorphic genes that encode differences in CMV-related human NK cell responses (Killer cell Immunoglobulin-like Receptors (
Identifiants
pubmed: 33807229
pii: ijms22073623
doi: 10.3390/ijms22073623
pmc: PMC8037729
pii:
doi:
Substances chimiques
CD57 Antigens
0
KLRC2 protein, human
0
KLRG1 protein, human
0
Lectins, C-Type
0
NK Cell Lectin-Like Receptor Subfamily C
0
Receptors, Immunologic
0
Receptors, KIR
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Medical Research Council
ID : NMRC/TA/010/2012
Organisme : Japan Society for the Promotion of Science
ID : 17H07303
Organisme : Japan Society for the Promotion of Science
ID : 18K09467
Organisme : Japan Agency for Medical Research and Development
ID : JP20jk0210029
Références
Am J Ophthalmol. 2008 May;145(5):834-40
pubmed: 18255045
J Biol Chem. 2013 Mar 22;288(12):8679-8690
pubmed: 23335510
Trends Immunol. 2016 Mar;37(3):233-243
pubmed: 26869205
Trends Microbiol. 2008 Dec;16(12):620-7
pubmed: 18976921
Immunogenetics. 2002 Nov;54(8):543-50
pubmed: 12439616
Immunity. 2006 Aug;25(2):331-42
pubmed: 16901727
Jpn J Ophthalmol. 2021 Mar;65(2):184-190
pubmed: 33694024
Blood. 2006 May 1;107(9):3624-31
pubmed: 16384928
Immunol Rev. 2002 Dec;190:40-52
pubmed: 12493005
Science. 2000 Feb 11;287(5455):1031
pubmed: 10669413
J Immunol. 2019 Oct 15;203(8):2301-2309
pubmed: 31519864
Crit Rev Immunol. 2002;22(5-6):463-82
pubmed: 12803322
Immunology. 2019 Apr;156(4):319-328
pubmed: 30570753
Tissue Antigens. 2005 Jun;65(6):556-63
pubmed: 15896204
Hum Immunol. 2015 Sep;76(9):663-6
pubmed: 26416088
Transplantation. 2007 Apr 15;83(7):964-72
pubmed: 17460569
Immunol Rev. 2006 Dec;214:56-72
pubmed: 17100876
J Exp Med. 2006 Mar 20;203(3):633-45
pubmed: 16533882
Tissue Antigens. 2007 Nov;70(5):415-22
pubmed: 17854430
Singapore Med J. 2000 Apr;41(4):151-5
pubmed: 11063178
Am J Ophthalmol. 2008 Dec;146(6):883-9.e1
pubmed: 19027423
Blood. 2008 Sep 15;112(6):2369-80
pubmed: 18583565
Hum Immunol. 2015 Dec;76(12):928-38
pubmed: 26027777
N Engl J Med. 1989 Jun 29;320(26):1731-5
pubmed: 2543925
Genes Immun. 2014 Oct;15(7):495-9
pubmed: 25008861
J Allergy Clin Immunol. 2013 Sep;132(3):515-525
pubmed: 23993353
Blood. 2010 Oct 7;116(14):2411-9
pubmed: 20581313
Blood. 2004 Dec 1;104(12):3664-71
pubmed: 15304389
Nature. 2005 Aug 4;436(7051):709-13
pubmed: 16079848
Mucosal Immunol. 2016 Jan;9(1):159-70
pubmed: 26080707
Ophthalmology. 2008 Feb;115(2):292-297.e3
pubmed: 17669498
Nature. 1986 Feb 20-26;319(6055):675-8
pubmed: 3951539
Nat Rev Immunol. 2020 Feb;20(2):113-127
pubmed: 31666730
J Immunol. 2018 Jun 15;200(12):3881-3889
pubmed: 29866770
Blood. 2013 Apr 4;121(14):2678-88
pubmed: 23325834
Br J Ophthalmol. 2010 Dec;94(12):1648-52
pubmed: 20576767
Ocul Immunol Inflamm. 2018;26(1):107-115
pubmed: 29172842
J Exp Med. 1998 Aug 3;188(3):497-503
pubmed: 9687527
Blood. 2006 Feb 1;107(3):1230-2
pubmed: 16239436
Am J Ophthalmol. 2012 Jun;153(6):1016-24.e5
pubmed: 22310076
J Infect Dis. 2014 Oct 1;210(7):1083-9
pubmed: 24737799
Nat Genet. 2007 Sep;39(9):1092-9
pubmed: 17694054
Immunogenetics. 2016 Feb;68(2):133-44
pubmed: 26649563
Am J Transplant. 2014 Jan;14(1):156-62
pubmed: 24369024
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14725-32
pubmed: 21825173
J Immunol. 2001 Mar 1;166(5):2992-3001
pubmed: 11207248
Nat Rev Immunol. 2005 Mar;5(3):201-14
pubmed: 15719024
J Immunol. 2016 Apr 15;196(8):3398-410
pubmed: 26962229
Nature. 2009 Jan 29;457(7229):557-61
pubmed: 19136945
Aging Cell. 2013 Jun;12(3):381-7
pubmed: 23442093
Semin Immunol. 2014 Apr;26(2):145-51
pubmed: 24666761