Emerging Roles of TRIM8 in Health and Disease.
JAK-STAT
NF-κB
TRIM8
p53
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 03 2021
05 03 2021
Historique:
received:
22
01
2021
revised:
24
02
2021
accepted:
01
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
20
11
2021
Statut:
epublish
Résumé
The superfamily of TRIM (TRIpartite Motif-containing) proteins is one of the largest groups of E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly increased in recent years. In this review, we analyze the regulation of TRIM8 gene expression and how it is involved in many cell reactions in response to different stimuli such as genotoxic stress and attacks by viruses or bacteria, playing a central role in the immune response and orchestrating various fundamental biological processes such as cell survival, carcinogenesis, autophagy, apoptosis, differentiation and inflammation. Moreover, we show how TRIM8 functions are not limited to ubiquitination, and contrasting data highlight its role either as an oncogene or as a tumor suppressor gene, acting as a "double-edged weapon". This is linked to its involvement in the selective regulation of three pivotal cellular signaling pathways: the p53 tumor suppressor, NF-κB and JAK-STAT pathways. Lastly, we describe how TRIM8 dysfunctions are linked to inflammatory processes, autoimmune disorders, rare developmental and cardiovascular diseases, ischemia, intellectual disability and cancer.
Identifiants
pubmed: 33807506
pii: cells10030561
doi: 10.3390/cells10030561
pmc: PMC7998878
pii:
doi:
Substances chimiques
Carrier Proteins
0
Nerve Tissue Proteins
0
TRIM8 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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