Nosocomial Pneumonia in the Era of Multidrug-Resistance: Updates in Diagnosis and Management.
hospital-acquired pneumonia
low-radiation CT
lung ultrasound
nosocomial pneumonia
novel antibiotics
rapid microbiological diagnosis
syndromic multiplex PCR panels
ventilator-associated pneumonia
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
05
01
2021
revised:
25
02
2021
accepted:
03
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Nosocomial pneumonia (NP), including hospital-acquired pneumonia in non-intubated patients and ventilator-associated pneumonia, is one of the most frequent hospital-acquired infections, especially in the intensive care unit. NP has a significant impact on morbidity, mortality and health care costs, especially when the implicated pathogens are multidrug-resistant ones. This narrative review aims to critically review what is new in the field of NP, specifically, diagnosis and antibiotic treatment. Regarding novel imaging modalities, the current role of lung ultrasound and low radiation computed tomography are discussed, while regarding etiological diagnosis, recent developments in rapid microbiological confirmation, such as syndromic rapid multiplex Polymerase Chain Reaction panels are presented and compared with conventional cultures. Additionally, the volatile compounds/electronic nose, a promising diagnostic tool for the future is briefly presented. With respect to NP management, antibiotics approved for the indication of NP during the last decade are discussed, namely, ceftobiprole medocaril, telavancin, ceftolozane/tazobactam, ceftazidime/avibactam, and meropenem/vaborbactam.
Identifiants
pubmed: 33807623
pii: microorganisms9030534
doi: 10.3390/microorganisms9030534
pmc: PMC8001201
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Infect Control Hosp Epidemiol. 2012 Mar;33(3):250-6
pubmed: 22314062
Antimicrob Agents Chemother. 2015 Dec;59(12):7232-9
pubmed: 26349830
J Clin Pharmacol. 2016 Jan;56(1):56-66
pubmed: 26096377
JAMA. 2007 Apr 11;297(14):1583-93
pubmed: 17426278
Eur Respir J. 2001 Jul;18(1):196-208
pubmed: 11510793
Respir Res. 2020 Feb 7;21(1):45
pubmed: 32033607
J Antimicrob Chemother. 2019 Nov 1;74(11):3211-3216
pubmed: 31365094
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992391
Tex Heart Inst J. 2004;31(4):345-8
pubmed: 15745283
Clin Infect Dis. 2016 Sep 1;63(5):e61-e111
pubmed: 27418577
Lancet Infect Dis. 2018 Mar;18(3):285-295
pubmed: 29254862
J Glob Antimicrob Resist. 2020 Mar;20:209-213
pubmed: 31351246
Chest. 1992 Feb;101(2):458-63
pubmed: 1735272
Sci Rep. 2015 Nov 26;5:17179
pubmed: 26608483
Antimicrob Agents Chemother. 2017 May 24;61(6):
pubmed: 28373193
Intensive Care Med. 2020 Jun;46(6):1170-1179
pubmed: 32306086
Thorax. 2017 Nov;72(11):1046-1048
pubmed: 27974525
Int J Antimicrob Agents. 2009 Jul;34(1):1-7
pubmed: 19261449
J Transl Med. 2020 May 27;18(1):213
pubmed: 32460856
Biochemistry. 1991 Oct 29;30(43):10408-15
pubmed: 1931965
Biomol Detect Quantif. 2017 Jun 28;13:1-6
pubmed: 29021968
Drugs. 2018 Apr;78(6):675-692
pubmed: 29671219
Antimicrob Agents Chemother. 2014 Jun;58(6):3091-9
pubmed: 24637685
Lancet Infect Dis. 2013 Aug;13(8):665-71
pubmed: 23622939
Drugs. 2007;67(7):1027-52
pubmed: 17488146
Clin Infect Dis. 2011 May;52 Suppl 4:S373-83
pubmed: 21460299
Antimicrob Agents Chemother. 2014 Jul;58(7):3882-8
pubmed: 24777091
Semin Respir Crit Care Med. 2009 Feb;30(1):36-45
pubmed: 19199185
Intensive Care Med. 2018 Dec;44(12):2302-2304
pubmed: 30350171
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3227-31
pubmed: 26976862
Clin Infect Dis. 2013 Nov;57(9):1237-45
pubmed: 23899684
Diagn Microbiol Infect Dis. 2019 Jul;94(3):304-313
pubmed: 30808530
Am J Health Syst Pharm. 2007 Nov 15;64(22):2335-48
pubmed: 17989443
Antimicrob Agents Chemother. 2019 Feb 26;63(3):
pubmed: 30642936
Int J Crit Illn Inj Sci. 2015 Oct-Dec;5(4):256-64
pubmed: 26807395
Intensive Care Med. 2019 Sep;45(9):1200-1211
pubmed: 31418060
J Clin Pharmacol. 2009 Jul;49(7):816-23
pubmed: 19443680
Biomed Eng Online. 2002 Oct 16;1:4
pubmed: 12437783
Antimicrob Agents Chemother. 2018 Nov 26;62(12):
pubmed: 30275082
Eur J Clin Microbiol Infect Dis. 2021 Jan;40(1):219-224
pubmed: 32729059
Int J Antimicrob Agents. 2019 Mar;53(3):211-224
pubmed: 30394301
Clin Infect Dis. 2014 Jul 1;59(1):51-61
pubmed: 24723282
Drugs. 2014 Jan;74(1):31-51
pubmed: 24352909
Int J Infect Dis. 2017 Sep;62:39-43
pubmed: 28610832
Respir Med. 2015 Nov;109(11):1454-9
pubmed: 26440675
Antimicrob Resist Infect Control. 2019 Jan 5;8:4
pubmed: 30627428
Crit Care Med. 2009 Aug;37(8):2360-8
pubmed: 19531951
PLoS One. 2016 Feb 18;11(2):e0149541
pubmed: 26890675
J Hosp Infect. 2016 Mar;92(3):273-9
pubmed: 26810613
J Clin Microbiol. 2019 Jul 26;57(8):
pubmed: 31167848
Anesthesiology. 2015 Feb;122(2):437-47
pubmed: 25501898
Am J Respir Crit Care Med. 2005 Feb 15;171(4):388-416
pubmed: 15699079
Antimicrob Agents Chemother. 2015 Oct;59(10):6248-55
pubmed: 26248364
Antimicrob Agents Chemother. 2017 Oct 24;61(11):
pubmed: 28848018
Pharmacotherapy. 2010 Feb;30(2):136-43
pubmed: 20099988
J Antimicrob Chemother. 2008 Jul;62(1):5-34
pubmed: 18445577
Clin Infect Dis. 2017 Jul 1;65(1):110-120
pubmed: 29017262
Antimicrob Agents Chemother. 2007 Mar;51(3):826-30
pubmed: 17145788
Antimicrob Resist Infect Control. 2019 Jul 29;8:127
pubmed: 31384432
AJR Am J Roentgenol. 1997 Oct;169(4):967-75
pubmed: 9308446
Expert Rev Anti Infect Ther. 2020 Jul;18(7):643-655
pubmed: 32297801
J Antimicrob Chemother. 2015;70(6):1650-8
pubmed: 25645206
Antimicrob Agents Chemother. 2015 Aug;59(8):4856-60
pubmed: 26033723
Front Microbiol. 2015 Aug 05;6:791
pubmed: 26300860
Chest. 2005 Jan;127(1):213-9
pubmed: 15653986
Biophys J. 2019 May 7;116(9):1650-1657
pubmed: 31010666
Future Microbiol. 2010 Nov;5(11):1733-54
pubmed: 21133692
J Antimicrob Chemother. 2012 Jun;67(6):1354-8
pubmed: 22441578
N Engl J Med. 1996 Dec 19;335(25):1864-9
pubmed: 8948561
Antimicrob Agents Chemother. 2009 Oct;53(10):4217-24
pubmed: 19620338
J Antimicrob Chemother. 2017 Aug 1;72(8):2278-2289
pubmed: 28520867
Crit Care Med. 1982 Jan;10(1):29-30
pubmed: 7056051
Curr Opin Crit Care. 2020 Oct;26(5):442-449
pubmed: 32739969
Int J Antimicrob Agents. 2012 Jan;39(1):86-9
pubmed: 22041508
Curr Opin Microbiol. 2011 Oct;14(5):550-5
pubmed: 21840248
J Antimicrob Chemother. 2017 Nov 1;72(11):3079-3084
pubmed: 28961968
Int J Antimicrob Agents. 2015 Jun;45(6):641-6
pubmed: 25748553
J Clin Microbiol. 2006 Jun;44(6):2039-45
pubmed: 16757595
J Breath Res. 2016 Jun 07;10(2):027102
pubmed: 27272697
Chest. 2002 Jul;122(1):262-8
pubmed: 12114368
Am J Respir Crit Care Med. 2019 Mar 15;199(6):701-714
pubmed: 30372119
J Antimicrob Chemother. 2012 Oct;67(10):2463-9
pubmed: 22773741
Int J Antimicrob Agents. 2012 Mar;39(3):240-6
pubmed: 22230331
Laryngoscope. 2002 Jun;112(6):975-9
pubmed: 12160294
Clin Infect Dis. 2015 Sep 15;61 Suppl 2:S58-68
pubmed: 26316559
Pharmacotherapy. 2019 Dec;39(12):1216-1222
pubmed: 31596506
Neurologia. 2012 Jan;27(1):34-8
pubmed: 21570745
Antimicrob Agents Chemother. 2019 Feb 26;63(3):
pubmed: 30617090
Antimicrob Agents Chemother. 2020 Apr 21;64(5):
pubmed: 32094135
Antimicrob Agents Chemother. 2012 Jun;56(6):3086-91
pubmed: 22450972
Antimicrob Agents Chemother. 2005 Mar;49(3):1127-34
pubmed: 15728913
Intensive Care Med. 2020 May;46(5):888-906
pubmed: 32157357
J Thorac Imaging. 2019 May;34(3):179-186
pubmed: 30870305
Intensive Care Med. 2020 Jun;46(6):1127-1153
pubmed: 32383061
J Intensive Care Med. 2021 Mar;36(3):304-312
pubmed: 31818178
Diagn Microbiol Infect Dis. 2011 Mar;69(3):348-55
pubmed: 21353964
Expert Rev Anti Infect Ther. 2018 Apr;16(4):307-320
pubmed: 29493397
J Thorac Dis. 2016 Jun;8(6):1356-65
pubmed: 27293860
J Thorac Dis. 2016 Oct;8(10):2822-2831
pubmed: 27867558
Diagn Microbiol Infect Dis. 2015 May;82(1):65-9
pubmed: 25737290
Trends Mol Med. 2015 Oct;21(10):633-644
pubmed: 26432020
Crit Care Med. 2018 Jul;46(7):e707-e714
pubmed: 29601314
Antimicrob Agents Chemother. 2017 May 24;61(6):
pubmed: 28396547
Rev Esp Quimioter. 2019 Sep;32 Suppl 3:3-10
pubmed: 31364335
Antimicrob Agents Chemother. 2018 Sep 24;62(10):
pubmed: 30082292
Antimicrob Agents Chemother. 2017 Nov 22;61(12):
pubmed: 29038260
Front Pharmacol. 2020 May 29;11:786
pubmed: 32547394
Drugs. 1995 Apr;49(4):577-617
pubmed: 7789291
Clin Infect Dis. 2015 May 15;60(10):1462-71
pubmed: 25670823
Int J Infect Dis. 2020 Jun;95:326-331
pubmed: 32179139
JAMA Intern Med. 2013 Dec 9-23;173(22):2039-46
pubmed: 23999949
Sensors (Basel). 2017 Nov 24;17(12):
pubmed: 29186754
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8
pubmed: 22753474
J Breath Res. 2016 Jun 16;10(3):036001
pubmed: 27310311
Crit Care. 2021 Jan 11;25(1):25
pubmed: 33430915
Antimicrob Agents Chemother. 2009 Aug;53(8):3294-301
pubmed: 19451287
Ann Transl Med. 2018 Nov;6(21):418
pubmed: 30581826
Chest. 1995 Nov;108(5):1345-8
pubmed: 7587439
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3163-9
pubmed: 26926648
Curr Opin Pulm Med. 2020 May;26(3):241-248
pubmed: 32068574
J Pharmacol Pharmacother. 2011 Apr;2(2):135-7
pubmed: 21772784
Eur J Clin Pharmacol. 2018 Dec;74(12):1671-1672
pubmed: 30094703
Antimicrob Agents Chemother. 2017 Nov 22;61(12):
pubmed: 28947473
Lung Cancer. 2018 Nov;125:223-229
pubmed: 30429025
Chest. 2014 Dec;146(6):1578-1585
pubmed: 25144666
Diagn Microbiol Infect Dis. 2018 May;91(1):77-84
pubmed: 29395713
JAMA. 2018 Feb 27;319(8):788-799
pubmed: 29486041
Antimicrob Agents Chemother. 2018 Mar 27;62(4):
pubmed: 29437614
J Food Drug Anal. 2019 Apr;27(2):404-414
pubmed: 30987712
Antimicrob Agents Chemother. 2017 Aug 24;61(9):
pubmed: 28674053
J Breath Res. 2014 Sep;8(3):034001
pubmed: 24946087
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4490-500
pubmed: 27161636
Antimicrob Agents Chemother. 2008 Jun;52(6):2089-96
pubmed: 18378703
Antimicrob Agents Chemother. 2017 Sep 22;61(10):
pubmed: 28739787
Clin Pharmacokinet. 2016 Dec;55(12):1507-1520
pubmed: 27272266
Clin Pharmacokinet. 2011 Oct;50(10):637-64
pubmed: 21895037
J Biol Chem. 2013 Sep 27;288(39):27960-71
pubmed: 23913691
Bioorg Med Chem Lett. 2003 Dec 1;13(23):4165-8
pubmed: 14622994
Expert Rev Anti Infect Ther. 2019 Jul;17(7):523-533
pubmed: 31237462
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4743-9
pubmed: 27216074
J Clin Microbiol. 2013 May;51(5):1490-5
pubmed: 23467602
Infect Drug Resist. 2018 Sep 12;11:1461-1472
pubmed: 30254477
Ther Clin Risk Manag. 2016 Dec 01;12:1811-1826
pubmed: 27942218
Chest. 2009 Oct;136(4):1014-1020
pubmed: 19809049
Antimicrob Agents Chemother. 2017 Jun 27;61(7):
pubmed: 28416553
Respir Care. 2019 May;64(5):519-527
pubmed: 30670664
Crit Care Med. 2014 Mar;42(3):601-9
pubmed: 24158167
Chem Rev. 2005 Feb;105(2):395-424
pubmed: 15700950
Crit Care Med. 2018 Nov;46(11):1761-1768
pubmed: 30048331
Eur Respir J. 2018 May 30;51(5):
pubmed: 29650558
J Microbiol Immunol Infect. 2019 Dec;52(6):920-928
pubmed: 31806539
Microorganisms. 2019 Aug 18;7(8):
pubmed: 31426596
Breathe (Sheff). 2019 Mar;15(1):81-83
pubmed: 30838065
Int J Antimicrob Agents. 2019 Apr;53(4):408-415
pubmed: 30415002
Infect Dis Ther. 2018 Dec;7(4):439-455
pubmed: 30270406
J Antimicrob Chemother. 2020 Jun 1;75(6):1546-1553
pubmed: 32211756
Antimicrob Agents Chemother. 2017 Feb 23;61(3):
pubmed: 28031201
Antimicrob Agents Chemother. 2017 Aug 24;61(9):
pubmed: 28674059
Clin Infect Dis. 2010 Nov 1;51(9):1074-80
pubmed: 20879856
Drugs. 2018 Aug;78(12):1259-1270
pubmed: 30128699
J Clin Microbiol. 2020 Jun 24;58(7):
pubmed: 32350043
Crit Care. 2019 Dec 12;23(1):406
pubmed: 31831032
Antimicrob Agents Chemother. 2014;58(2):1218-23
pubmed: 24277025
Eur J Clin Microbiol Infect Dis. 2017 Nov;36(11):1999-2006
pubmed: 27287765
Eur J Clin Microbiol Infect Dis. 2020 Feb;39(2):281-286
pubmed: 31654147
Intensive Care Med. 2020 May;46(5):1063-1064
pubmed: 32193564
PLoS One. 2016 Aug 04;11(8):e0160643
pubmed: 27490684
Antimicrob Agents Chemother. 2017 Apr 24;61(5):
pubmed: 28223379
Eur J Clin Microbiol Infect Dis. 2019 Jun;38(6):1171-1178
pubmed: 30859358
Microbiology (Reading). 2012 Dec;158(Pt 12):3044-3053
pubmed: 23059976
J Clin Med. 2019 Oct 16;8(10):
pubmed: 31623141
Curr Opin Pulm Med. 2007 May;13(3):159-69
pubmed: 17414122
Crit Care. 2020 Jan 10;24(1):11
pubmed: 31924240
J Clin Microbiol. 2008 Apr;46(4):1232-40
pubmed: 18256230
Infect Dis (Lond). 2020 Jul;52(7):479-488
pubmed: 32319831
Clin Infect Dis. 2009 Aug 15;49(4):543-51
pubmed: 19583519
Antimicrob Agents Chemother. 2016 Apr 22;60(5):2849-57
pubmed: 26926635
J Vis Exp. 2019 Jan 16;(143):
pubmed: 30735183
Clin Pharmacokinet. 2018 Jul;57(7):797-816
pubmed: 29332251
BMJ Open. 2019 Mar 8;9(3):e025486
pubmed: 30852546
Eur Respir J. 2017 Sep 10;50(3):
pubmed: 28890434
J Antimicrob Chemother. 2004 Aug;54(2):410-7
pubmed: 15254025
Eur Respir Rev. 2020 Aug 4;29(157):
pubmed: 32759376
Future Microbiol. 2018 Jul;13:971-983
pubmed: 29692218
Radiologe. 2017 Jan;57(1):13-21
pubmed: 27921227
J Antimicrob Chemother. 2004 May;53(5):797-803
pubmed: 15028667
Chest. 2009 Jun;135(6):1421-1425
pubmed: 19225063
Crit Care. 2020 Jun 19;24(1):366
pubmed: 32560662
J Antimicrob Chemother. 2015 Oct;70(10):2862-9
pubmed: 26133566
Matrix Biol. 2018 Aug;68-69:404-421
pubmed: 29408012
Lancet Infect Dis. 2019 Dec;19(12):1299-1311
pubmed: 31563344
Crit Care. 2020 Jun 26;24(1):378
pubmed: 32586347
J Antimicrob Chemother. 2014 Nov;69(11):3006-10
pubmed: 24990867
Clin Ther. 2018 Mar;40(3):406-414.e2
pubmed: 29454592
Respirology. 2016 Feb;21(2):321-8
pubmed: 26545565
Antimicrob Agents Chemother. 2019 Jul 25;63(8):
pubmed: 31182535
J Breath Res. 2015 Jan 05;9(1):016004
pubmed: 25557917