Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats.
Animals
Biomarkers
/ metabolism
CD36 Antigens
/ genetics
Chemokine CCL2
/ genetics
Diet, High-Fat
/ adverse effects
Dietary Supplements
Fruit and Vegetable Juices
Gene Expression Regulation
Intra-Abdominal Fat
/ drug effects
Macrophages
/ drug effects
Male
Obesity
/ diet therapy
Panniculitis
/ diet therapy
Prunus avium
/ chemistry
Rats, Wistar
Seeds
inflammation
obesity
tart cherries
visceral adipose tissue
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
04
12
2020
revised:
03
02
2021
accepted:
25
02
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
2
6
2021
Statut:
epublish
Résumé
Tart cherries ( This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation. Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.
Sections du résumé
BACKGROUND
BACKGROUND
Tart cherries (
METHODS
METHODS
This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed
RESULTS
RESULTS
No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation.
CONCLUSION
CONCLUSIONS
Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.
Identifiants
pubmed: 33807712
pii: molecules26051403
doi: 10.3390/molecules26051403
pmc: PMC7961347
pii:
doi:
Substances chimiques
Biomarkers
0
CD36 Antigens
0
Ccl2 protein, rat
0
Chemokine CCL2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Camerino
ID : Fondo Ateneo Per la Ricerca 2014/2015
Références
Eur J Nutr. 2016 Jun;55(4):1695-705
pubmed: 26163338
Crit Rev Food Sci Nutr. 2019;59(22):3549-3563
pubmed: 30040438
Development. 2013 Oct;140(19):3939-49
pubmed: 24046315
J AOAC Int. 2005 Sep-Oct;88(5):1269-78
pubmed: 16385975
Front Cardiovasc Med. 2020 Feb 25;7:22
pubmed: 32158768
Annu Rev Food Sci Technol. 2010;1:163-87
pubmed: 22129334
Food Funct. 2019 Jul 17;10(7):4423-4431
pubmed: 31287117
Metabolism. 2019 Mar;92:61-70
pubmed: 30586573
JAMA. 2013 Jan 2;309(1):71-82
pubmed: 23280227
J Agric Food Chem. 2002 Oct 9;50(21):6172-81
pubmed: 12358498
Nutrients. 2020 Feb 27;12(3):
pubmed: 32120798
Nutr Hosp. 2012 Jul-Aug;27(4):978-90
pubmed: 23165533
J Endocrinol. 2004 Apr;181(1):1-10
pubmed: 15072562
Infect Disord Drug Targets. 2009 Aug;9(4):400-14
pubmed: 19689382
Front Immunol. 2015 Feb 25;6:80
pubmed: 25762999
Phytochemistry. 2003 Nov;64(5):923-33
pubmed: 14561507
Front Pharmacol. 2018 Dec 04;9:1310
pubmed: 30564116
J Agric Food Chem. 2014 Dec 24;62(51):12332-45
pubmed: 25495123
J Clin Invest. 2003 Dec;112(12):1821-30
pubmed: 14679177
J Med Food. 2009 Oct;12(5):935-42
pubmed: 19857054
J Agric Food Chem. 2010 Apr 14;58(7):3970-6
pubmed: 20148514
J Clin Invest. 2003 Dec;112(12):1785-8
pubmed: 14679172
J Clin Med. 2019 Aug 24;8(9):
pubmed: 31450565
Br J Sports Med. 2006 Aug;40(8):679-83; discussion 683
pubmed: 16790484
Eur J Nutr. 2021 Aug;60(5):2695-2707
pubmed: 33386893
Nutrients. 2018 Mar 17;10(3):
pubmed: 29562604
FEBS Lett. 2017 Oct;591(19):3061-3088
pubmed: 28677122
Front Endocrinol (Lausanne). 2015 Feb 19;6:19
pubmed: 25745415
Diabetes. 1997 Jan;46(1):3-10
pubmed: 8971073
Nutrients. 2020 May 04;12(5):
pubmed: 32375317
Br J Nutr. 2015 Oct 28;114(8):1123-31
pubmed: 26314315
Plant Foods Hum Nutr. 2009 Dec;64(4):231-7
pubmed: 19763832
Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E975-88
pubmed: 24595303
Nat Prod Rep. 2004 Aug;21(4):539-73
pubmed: 15282635
Science. 1993 Jan 1;259(5091):87-91
pubmed: 7678183
Mol Cell Biol. 1990 Feb;10(2):561-8
pubmed: 2405250
Food Res Int. 2017 Jul;97:15-26
pubmed: 28578036
Nutrients. 2019 Aug 21;11(9):
pubmed: 31438590
Diabetologia. 2014 Mar;57(3):562-71
pubmed: 24343232
J Nat Prod. 1999 May;62(5):802
pubmed: 10347382
Clin Chem. 2008 Jun;54(6):945-55
pubmed: 18436717
Prostaglandins Leukot Essent Fatty Acids. 2014 Feb-Mar;90(2-3):77-84
pubmed: 24411719
Am J Clin Nutr. 2012 Apr;95(4):925-33
pubmed: 22357723
Food Funct. 2018 Oct 17;9(10):5290-5300
pubmed: 30255184
J Med Food. 2010 Aug;13(4):905-10
pubmed: 20482278
Nature. 2008 Jun 5;453(7196):783-7
pubmed: 18454136
Biomed Res Int. 2013;2013:985093
pubmed: 24527432
J Agric Food Chem. 2008 Feb 13;56(3):647-53
pubmed: 18211017
Food Technol Biotechnol. 2015 Jun;53(2):215-222
pubmed: 27904351
Drug Metab Rev. 2014 Nov;46(4):508-20
pubmed: 25347327
Nutrients. 2017 Oct 01;9(10):
pubmed: 28974032
J Nutr. 2009 Aug;139(8):1510-6
pubmed: 19515743
Metabolism. 2008 Dec;57(12):1704-10
pubmed: 19013294
Nutr Metab (Lond). 2010 Jan 20;7:5
pubmed: 20180981
Nutrients. 2018 Oct 25;10(11):
pubmed: 30366378
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4
pubmed: 388439
Front Endocrinol (Lausanne). 2015 Apr 24;6:55
pubmed: 25964776
Curr Opin Lipidol. 2013 Feb;24(1):25-33
pubmed: 23254472
Lancet. 2011 Mar 26;377(9771):1085-95
pubmed: 21397319
Mol Cell Endocrinol. 2010 Mar 25;316(2):129-39
pubmed: 19723556
Circulation. 2006 Feb 14;113(6):898-918
pubmed: 16380542
Nutr Neurosci. 2005 Apr;8(2):111-20
pubmed: 16053243
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
J Clin Invest. 2006 Jan;116(1):115-24
pubmed: 16341265
Diabetes. 2007 Sep;56(9):2260-73
pubmed: 17563062
Pol J Vet Sci. 2016;19(2):441-6
pubmed: 27487522
J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56
pubmed: 15181022
Molecules. 2010 Oct 12;15(10):6993-7005
pubmed: 20944519
J Clin Invest. 2004 Dec;114(12):1752-61
pubmed: 15599400
Circulation. 2000 Nov 14;102(20):2555-9
pubmed: 11076833
Lipids Health Dis. 2009 Jun 26;8:25
pubmed: 19558671
Cell. 2014 Jan 16;156(1-2):20-44
pubmed: 24439368