Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs.
microRNA
preeclampsia
two-stage model
uterine artery remodeling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Mar 2021
19 Mar 2021
Historique:
received:
28
02
2021
revised:
15
03
2021
accepted:
17
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
29
4
2021
Statut:
epublish
Résumé
Preeclampsia affects about 3-8% of all pregnancies. It represents a complex and multifaceted syndrome with at least several potential pathways leading to the development of disease. The main dogma in preeclampsia is the two-stage model of disease. Stage 1 (placental stage) takes place in early pregnancy and is thought to be impaired placentation due to inadequate trophoblastic invasion of the maternal spiral arteries that leads to reduced placental perfusion and release of numerous biological factors causing endothelial damage and development of acute maternal syndrome with systemic multiorgan failure (stage 2-the onset of maternal clinical symptoms, maternal stage). Recently, in the light of the vast body of evidence, two-stage model of preeclampsia has been updated with a few novel pathways leading to clinical manifestation in the second part of pregnancy. This paper reviews current state of knowledge about pathophysiology of preeclampsia and places particular focus on the recent advances in understanding of uterine artery remodeling alterations, as well as the role of microRNAs in preeclampsia.
Identifiants
pubmed: 33808559
pii: ijms22063132
doi: 10.3390/ijms22063132
pmc: PMC8003365
pii:
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Lancet. 2013 Jul 13;382(9887):104-6
pubmed: 23727168
Eur J Heart Fail. 2010 Aug;12(8):826-32
pubmed: 20525986
J Reprod Immunol. 2019 Sep;134-135:1-10
pubmed: 31301487
Gene. 2017 Sep 5;627:543-548
pubmed: 28694210
J Biomed Biotechnol. 2012;2012:305964
pubmed: 22570525
Clin Epigenetics. 2018 Mar 2;10:28
pubmed: 29507646
Mol Med Rep. 2019 Jun;19(6):4655-4662
pubmed: 31059003
Hypertension. 2014 Oct;64(4):839-45
pubmed: 24980667
BMJ. 2001 Nov 24;323(7323):1213-7
pubmed: 11719411
Placenta. 2017 Apr;52:139-145
pubmed: 28131318
Biol Reprod. 2013 May 23;88(5):130
pubmed: 23575145
Exp Ther Med. 2019 Jul;18(1):826-832
pubmed: 31281456
PLoS One. 2015 Apr 10;10(4):e0119547
pubmed: 25860260
PLoS One. 2017 Feb 9;12(2):e0171756
pubmed: 28182660
J Matern Fetal Neonatal Med. 2020 Sep;33(18):3116-3124
pubmed: 30700172
Hypertens Pregnancy. 2020 Nov;39(4):379-386
pubmed: 32538210
Cell Death Dis. 2018 Jan 16;9(2):16
pubmed: 29339719
Int J Mol Sci. 2019 Feb 02;20(3):
pubmed: 30717334
Obstet Gynecol. 2017 Apr;129(4):e90-e95
pubmed: 28333820
J Obstet Gynaecol Can. 2018 Sep;40(9):1129-1138
pubmed: 29934233
Am J Obstet Gynecol. 2008 Aug;199(2):122.e1-122.e11
pubmed: 18539259
N Engl J Med. 2017 Aug 17;377(7):613-622
pubmed: 28657417
Biomed Rep. 2020 Nov;13(5):41
pubmed: 32934814
Placenta. 1991 Jul-Aug;12(4):301-8
pubmed: 1946241
Sci Rep. 2021 Feb 4;11(1):3048
pubmed: 33542402
Mol Cell Endocrinol. 2019 Jun 15;490:57-67
pubmed: 30981734
Mol Cell Endocrinol. 2020 Mar 1;503:110699
pubmed: 31899258
Int J Mol Sci. 2021 Jan 12;22(2):
pubmed: 33445783
PLoS One. 2015 Sep 22;10(9):e0138383
pubmed: 26394310
Exp Ther Med. 2019 Apr;17(4):2623-2631
pubmed: 30906454
Circulation. 2004 Nov 9;110(19):3121-8
pubmed: 15520318
Biofactors. 2019 Sep;45(5):712-724
pubmed: 31343798
J Pregnancy. 2020 Dec 16;2020:8369645
pubmed: 33381317
Mediators Inflamm. 2020 Oct 5;2020:3864941
pubmed: 33082708
Hypertens Pregnancy. 2017 Feb;36(1):90-99
pubmed: 27835046
J Cell Physiol. 2019 Feb;234(2):1052-1061
pubmed: 30256424
Cells. 2019 Sep 13;8(9):
pubmed: 31540324
Mol Ther. 2018 Sep 5;26(9):2189-2205
pubmed: 30061037
Hypertens Res. 2019 Feb;42(2):155-164
pubmed: 30518985
Comp Biochem Physiol Part D Genomics Proteomics. 2015 Dec;16:83-98
pubmed: 26363379
Medicine (Baltimore). 2017 May;96(18):e6509
pubmed: 28471953
Circ Cardiovasc Qual Outcomes. 2017 Feb;10(2):
pubmed: 28228456
Placenta. 2007 May-Jun;28(5-6):399-407
pubmed: 17098281
Front Immunol. 2019 Jun 19;10:1240
pubmed: 31275299
Inflamm Res. 2014 Mar;63(3):179-89
pubmed: 24270813
Reprod Sci. 2019 Aug;26(8):1121-1129
pubmed: 30376765
Int J Cardiol. 2017 Dec 15;249:402-409
pubmed: 29121743
Anesthesiol Clin. 2017 Mar;35(1):95-106
pubmed: 28131123
Hypertension. 2020 Mar;75(3):762-771
pubmed: 31983308
Medicine (Baltimore). 2017 Jul;96(28):e7515
pubmed: 28700503
Int J Mol Sci. 2019 Aug 30;20(17):
pubmed: 31480243
Epigenomics. 2021 Feb;13(4):257-269
pubmed: 33471580
Physiol Res. 2021 Mar 17;70(1):67-78
pubmed: 33453713
Free Radic Biol Med. 2017 Mar;104:185-198
pubmed: 28087411
Int J Mol Sci. 2020 Dec 26;22(1):
pubmed: 33375253
Physiol Rev. 2016 Oct;96(4):1297-325
pubmed: 27535639
Cardiovasc Res. 2008 May 1;78(2):333-40
pubmed: 18006432
Cytokine. 2014 Jul;68(1):9-15
pubmed: 24787051
Reprod Sci. 2020 Oct;27(10):1932-1942
pubmed: 32548805
Prz Menopauzalny. 2019 Jun;18(2):99-109
pubmed: 31485207
Am J Pathol. 2015 May;185(5):1334-43
pubmed: 25769431
J Hypertens. 2009 Oct;27(10):1955-9
pubmed: 19893428
Microrna. 2019;8(1):28-35
pubmed: 30101723
Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165354
pubmed: 30590104
Pregnancy Hypertens. 2018 Jul;13:291-310
pubmed: 29803330
Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):845-50
pubmed: 25561558
Reproduction. 2020 Dec;160(6):905-917
pubmed: 33112793
Int J Mol Cell Med. 2019 Fall;8(4):247-257
pubmed: 32587835
Hum Genet. 2021 Jan 12;:
pubmed: 33433680
Int J Mol Sci. 2018 May 17;19(5):
pubmed: 29772777
Int J Cardiol. 2019 Sep 15;291:158-167
pubmed: 31151766
Am J Obstet Gynecol. 2020 Oct 20;:
pubmed: 33096092
BMJ. 2019 Jul 15;366:l2381
pubmed: 31307997
Biol Reprod. 2006 May;74(5):896-904
pubmed: 16452465
Glycobiology. 2014 Oct;24(10):886-91
pubmed: 25138305
J Biol Chem. 2011 Dec 2;286(48):41862-41870
pubmed: 22002058
BJOG. 2021 Feb 4;:
pubmed: 33539617
Am J Obstet Gynecol. 2014 Feb;210(2):147.e1-8
pubmed: 24060448
Placenta. 2020 Sep 1;98:60-68
pubmed: 33039033
Curr Hypertens Rev. 2019;15(2):105-112
pubmed: 30663572
Am J Transl Res. 2020 Aug 15;12(8):4715-4727
pubmed: 32913544
BJOG. 2017 Jul;124(8):1246-1253
pubmed: 27770512
Adv Clin Exp Med. 2018 Jul;27(7):867-872
pubmed: 29962114
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S9.e1, S9-11
pubmed: 26428507
Curr Hypertens Rep. 2020 Sep 7;22(11):89
pubmed: 32893333
Reproduction. 2016 Jul;152(1):11-22
pubmed: 27256632
Am J Obstet Gynecol. 2020 May;222(5):497.e1-497.e12
pubmed: 31836544
Int J Mol Sci. 2019 Jun 11;20(11):
pubmed: 31212604
Med Sci Monit. 2020 Aug 03;26:e923901
pubmed: 32744262
J Clin Med. 2020 Jul 15;9(7):
pubmed: 32679789
Reprod Sci. 2019 Jun;26(6):766-773
pubmed: 30223723
Placenta. 2014 Nov;35(11):855-65
pubmed: 25266889
N Engl J Med. 2006 Sep 7;355(10):992-1005
pubmed: 16957146
Nat Rev Nephrol. 2014 Aug;10(8):466-80
pubmed: 25003615
Pregnancy Hypertens. 2019 Jul;17:49-53
pubmed: 31487655
Cells. 2020 Apr 16;9(4):
pubmed: 32316263
Arch Gynecol Obstet. 2021 Jan 26;:
pubmed: 33496844
Hypertension. 2014 Jun;63(6):1276-84
pubmed: 24664294
Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R336-R343
pubmed: 29718698
Int J Mol Sci. 2020 May 20;21(10):
pubmed: 32443673
Placenta. 2014 Feb;35 Suppl:S20-5
pubmed: 24477207
Placenta. 2009 Mar;30 Suppl A:S43-8
pubmed: 19081132
Lancet. 1993 Jun 5;341(8858):1447-51
pubmed: 8099148
Curr Drug Targets. 2017;18(10):1165-1170
pubmed: 28382860
Pregnancy Hypertens. 2017 Oct;10:207-212
pubmed: 29153681
Biochim Biophys Acta. 2006 Apr;1760(4):616-35
pubmed: 16478649
Cell Death Dis. 2020 Jul 23;11(7):560
pubmed: 32703931
Am J Obstet Gynecol. 2010 May;202(5):466.e1-7
pubmed: 20452491