Age-Related Palatal Wound Healing: An Experimental In Vivo Study.
inflammation
myofibroblasts
palate
rats
wound healing
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
19 Mar 2021
19 Mar 2021
Historique:
received:
09
02
2021
revised:
05
03
2021
accepted:
16
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
We assessed age-related excisional palatal mucoperiosteal wound closure in rats. A 4.2 mm diameter punch was used to create a secondary healing defect in the palate of Wistar rats. Study group-21, 18-month-old vs. control 21, 2-month-old males. The 2-dimensional area, maximum length and width of the soft tissue defect served as clinical outcome parameters. The dynamics of the initial three healing weeks were assessed. Semi-quantitative histomorphometric analysis of inflammation and myofibroblasts served for the evaluation of the inflammatory and proliferative wound healing phases. Complete wound closure was faster in the old rats. A dimensional related wound closure was observed in the young rats versus a symmetrical wound closure in the old rats. Inflammatory response was significantly delayed and of lower intensity in the old rats. Myofibroblastic response, representing the proliferative stage, was delayed and of lower intensity in the old rats, albeit not statistically significant. Reduced initial tissue damage due to decreased and delayed inflammatory response in the old rats ultimately led to faster clinical wound healing compared to the young rats, despite a statistically non-significant lower proliferative response in the old rats.
Identifiants
pubmed: 33808882
pii: biology10030240
doi: 10.3390/biology10030240
pmc: PMC8003724
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Periodontol. 1997 Feb;68(2):145-51
pubmed: 9058332
Eur J Oral Sci. 1999 Oct;107(5):344-51
pubmed: 10515199
Comp Biochem Physiol A Physiol. 1995 Jul;111(3):415-9
pubmed: 7614034
J Clin Periodontol. 2007 Feb;34(2):164-71
pubmed: 17309591
Arch Oral Biol. 2019 Sep;105:72-80
pubmed: 31288144
Int J Periodontics Restorative Dent. 1996 Apr;16(2):130-7
pubmed: 9084301
Arch Oral Biol. 1993 Jan;38(1):17-21
pubmed: 8442717
Periodontol 2000. 2016 Oct;72(1):96-107
pubmed: 27501493
Int J Oral Surg. 1982 Feb;11(1):44-51
pubmed: 6811457
J Clin Periodontol. 2018 Aug;45(8):977-985
pubmed: 29908088
J Dent Res. 2014 Jul;93(7):691-7
pubmed: 24776985
J Periodontol. 1978 Aug;49(8):403-5
pubmed: 288907
J Clin Periodontol. 1992 May;19(5):345-7
pubmed: 1517480
J Clin Periodontol. 2016 Nov;43(11):976-984
pubmed: 27330024
N Engl J Med. 1999 Sep 2;341(10):738-46
pubmed: 10471461
Aesthetic Plast Surg. 2000 Jan-Feb;24(1):34-8
pubmed: 10742467
J Craniomaxillofac Surg. 1995 Feb;23(1):27-30
pubmed: 7699079
J Periodontol. 1992 Apr;63(4 Suppl):322-31
pubmed: 1573546
J Cutan Med Surg. 2006 Mar-Apr;10(2):69-72
pubmed: 17241577
J Clin Periodontol. 2014 Apr;41 Suppl 15:S1-5
pubmed: 24640995
J Oral Maxillofac Surg. 2004 Jan;62(1):73-80
pubmed: 14699553
Plast Reconstr Surg. 1990 Sep;86(3):558-62
pubmed: 2385675
Periodontol 2000. 2017 Oct;75(1):317-329
pubmed: 28758299
Cancer Med. 2012 Oct;1(2):128-40
pubmed: 23342263
Clin Exp Otorhinolaryngol. 2016 Dec;9(4):358-365
pubmed: 27416739
Osteoarthritis Cartilage. 2012 Apr;20(4):256-60
pubmed: 22424462
Periodontol 2000. 2018 Feb;76(1):131-149
pubmed: 29193331
Clin Oral Investig. 2020 Dec;24(12):4385-4393
pubmed: 32333177
Int J Periodontics Restorative Dent. 2000 Jun;20(3):297-305
pubmed: 11203571
Brain Behav Immun. 2009 Jul;23(5):629-35
pubmed: 19111925
J Dent Res. 2015 Mar;94(3):395-402
pubmed: 25527254
J Indian Soc Periodontol. 2019 Mar-Apr;23(2):93-99
pubmed: 30983778