A First Phenotypic and Functional Characterization of Placental Extracellular Vesicles from Women with Multiple Sclerosis.
Cell Communication
/ genetics
Coculture Techniques
Cytokines
/ genetics
Decidua
/ immunology
Extracellular Vesicles
/ genetics
Female
Humans
Immunity
/ genetics
Immunomodulation
/ genetics
Multiple Sclerosis
/ genetics
Placenta
/ immunology
Pregnancy
Proteome
/ genetics
T-Lymphocytes, Regulatory
/ immunology
Trophoblasts
/ immunology
decidua
extracellular vesicles
multiple sclerosis
placenta
pregnancy
trophoblast
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Mar 2021
12 Mar 2021
Historique:
received:
23
02
2021
revised:
08
03
2021
accepted:
09
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
21
4
2021
Statut:
epublish
Résumé
Pregnancy is a unique situation of physiological immunomodulation, as well as a strong Multiple Sclerosis (MS) disease modulator whose mechanisms are still unclear. Both maternal (decidua) and fetal (trophoblast) placental cells secrete extracellular vesicles (EVs), which are known to mediate cellular communication and modulate the maternal immune response. Their contribution to the MS disease course during pregnancy, however, is unexplored. Here, we provide a first phenotypic and functional characterization of EVs isolated from cultures of term placenta samples of women with MS, differentiating between decidua and trophoblast. In particular, we analyzed the expression profile of 37 surface proteins and tested the functional role of placental EVs on mono-cultures of CD14
Identifiants
pubmed: 33809077
pii: ijms22062875
doi: 10.3390/ijms22062875
pmc: PMC8001892
pii:
doi:
Substances chimiques
Cytokines
0
Proteome
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione Italiana Sclerosi Multipla
ID : 2017/R/26
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