Oral and Intravenous Iron Therapy Differentially Alter the On- and Off-Tumor Microbiota in Anemic Colorectal Cancer Patients.
16S rRNA
anemia
colorectal cancer
gut microbiome
iron deficiency
iron supplementation
tumor microbiota
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Mar 2021
16 Mar 2021
Historique:
received:
04
02
2021
revised:
03
03
2021
accepted:
12
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Iron deficiency anemia is a common complication of colorectal cancer and may require iron therapy. Oral iron can increase the iron available to gut bacteria and may alter the colonic microbiota. We performed an intervention study to compare oral and intravenous iron therapy on the colonic tumor-associated (on-tumor) and paired non-tumor-associated adjacent (off-tumor) microbiota. Anemic patients with colorectal adenocarcinoma received either oral ferrous sulphate (
Identifiants
pubmed: 33809624
pii: cancers13061341
doi: 10.3390/cancers13061341
pmc: PMC8002270
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical Research Council
ID : MR/M009157/1
Pays : United Kingdom
Organisme : Research for Patient Benefit Programme
ID : PB-PG-0110-21041
Références
Front Microbiol. 2015 Nov 17;6:1282
pubmed: 26635751
J Agric Food Chem. 2010 Sep 22;58(18):10277-81
pubmed: 20799709
J Mol Biol. 2007 Feb 16;366(2):481-93
pubmed: 17173928
Front Cell Infect Microbiol. 2016 Dec 09;6:179
pubmed: 28018861
Nutrients. 2020 Aug 20;12(9):
pubmed: 32825236
Nat Rev Microbiol. 2012 Jun 25;10(8):575-82
pubmed: 22728587
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Front Microbiol. 2015 Oct 08;6:1046
pubmed: 26500615
Cancers (Basel). 2020 Oct 16;12(10):
pubmed: 33081401
Gut. 2020 Aug;69(8):1510-1519
pubmed: 32409589
Sci Rep. 2020 Feb 18;10(1):2860
pubmed: 32071370
Microbiol Mol Biol Rev. 2007 Sep;71(3):413-51
pubmed: 17804665
Bioinformatics. 2014 Nov 1;30(21):3123-4
pubmed: 25061070
Cancer Res. 2007 Apr 1;67(7):3263-8
pubmed: 17409434
Lancet. 2020 Sep 4;:
pubmed: 32896294
Nat Rev Cancer. 2013 May;13(5):342-55
pubmed: 23594855
Cell Host Microbe. 2013 May 15;13(5):509-519
pubmed: 23684303
Cancers (Basel). 2020 May 29;12(6):
pubmed: 32486066
Biomed Pharmacother. 2020 Apr;124:109873
pubmed: 31986412
Cancers (Basel). 2020 Dec 09;12(12):
pubmed: 33317136
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
Gut Microbes. 2018 Jul 4;9(4):369-373
pubmed: 29420132
Front Microbiol. 2020 Mar 26;11:512
pubmed: 32273874
Oncogene. 2008 Feb 7;27(7):966-75
pubmed: 17700530
Cell Rep. 2012 Aug 30;2(2):270-82
pubmed: 22884366
Gut. 2017 May;66(5):863-871
pubmed: 26848182
Acc Chem Res. 2017 Feb 21;50(2):331-340
pubmed: 28177216
PLoS One. 2018 Oct 11;13(10):e0202460
pubmed: 30308045
Int J Colorectal Dis. 2017 Nov;32(11):1617-1624
pubmed: 28889320
Gut. 2017 Apr;66(4):633-643
pubmed: 26992426
Gastroenterology. 2020 Jan;158(2):322-340
pubmed: 31586566
Cancer Causes Control. 2018 Mar;29(3):389-397
pubmed: 29411204
Environ Microbiol. 2017 Jan;19(1):29-41
pubmed: 27928878
Gut Microbes. 2020 Jul 3;11(4):944-961
pubmed: 32138587
PLoS One. 2013 Nov 06;8(11):e78850
pubmed: 24223168
Pak J Med Sci. 2016 May-Jun;32(3):604-7
pubmed: 27375698
Microorganisms. 2019 Feb 28;7(3):
pubmed: 30823471
J Altern Complement Med. 2014 Jun;20(6):479-85
pubmed: 24738579
mSystems. 2018 Mar 27;3(2):
pubmed: 29629420
Biochem Pharmacol. 2016 Mar 1;103:53-63
pubmed: 26774455
Br J Surg. 2017 Feb;104(3):214-221
pubmed: 28092401
Front Immunol. 2016 Dec 27;7:651
pubmed: 28082985
FASEB J. 2020 Feb;34(2):3006-3020
pubmed: 31912587
Nat Biotechnol. 2019 Aug;37(8):852-857
pubmed: 31341288