Caspase-Cleaved Keratin 18 Measurements Identified Ongoing Liver Injury after Bariatric Surgery.
M30
NAFLD
NASH
cytokeratin 18
gastric bypass
keratin 18
non-alcoholic fatty liver disease
non-invasive biomarkers
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
16 Mar 2021
16 Mar 2021
Historique:
received:
18
02
2021
revised:
09
03
2021
accepted:
11
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Bariatric surgery has emerged as an effective treatment option in morbidly obese patients with non-alcoholic fatty liver disease (NAFLD). However, worsening or new onset of non-alcoholic steatohepatitis (NASH) and fibrosis have been observed. Caspase-cleaved keratin 18 (ccK18) has been established as a marker of hepatocyte apoptosis, a key event in NASH development. Thus, ccK18 measurements might be feasible to monitor bariatric surgery patients. Clinical data and laboratory parameters were collected from 39 patients undergoing laparoscopic Roux-en-Y gastric bypass at six timepoints, prior to surgery until one year after the procedure. ccK18 levels were measured and a high-throughput analysis of serum adipokines and cytokines was carried out. Half of the cohort's patients (20/39) presented with ccK18 levels indicative of progressed liver disease. 21% had a NAFLD-fibrosis score greater than 0.676, suggesting significant fibrosis. One year after surgery, a mean weight loss of 36.87% was achieved. Six and twelve months after surgery, ccK18 fragments were significantly reduced compared to preoperative levels (
Identifiants
pubmed: 33809676
pii: jcm10061233
doi: 10.3390/jcm10061233
pmc: PMC8002276
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Von-Behring-Röntgen-Stiftung
ID : 66-0008
Organisme : Deutsche Forschungsgemeinschaft
ID : RO957/10-1
Organisme : Uniklinikum Giessen und Marburg
ID : 10/2013 GI
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