Niclosamide-Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment.
Tween 60
bioavailability
drug delivery
montmorillonite
niclosamide
poorly-soluble drug
solubility enhancement
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
26 Mar 2021
26 Mar 2021
Historique:
received:
28
02
2021
revised:
22
03
2021
accepted:
23
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
4
2021
Statut:
epublish
Résumé
Niclosamide (NIC), a conventional anthelmintic agent, is emerging as a repurposed drug for COVID-19 treatment. However, the clinical efficacy is very limited due to its low oral bioavailability resulting from its poor aqueous solubility. In the present study, a new hybrid drug delivery system made of NIC, montmorillonite (MMT), and Tween 60 is proposed to overcome this obstacle. At first, NIC molecules were immobilized into the interlayer space of cationic clay, MMT, to form NIC-MMT hybrids, which could enhance the solubility of NIC, and then the polymer surfactant, Tween 60, was further coated on the external surface of NIC-MMT to improve the release rate and the solubility of NIC and eventually the bioavailability under gastrointestinal condition when orally administered. Finally, we have performed an in vivo pharmacokinetic study to compare the oral bioavailability of NIC for the Tween 60-coated NIC-MMT hybrid with Yomesan
Identifiants
pubmed: 33810527
pii: polym13071044
doi: 10.3390/polym13071044
pmc: PMC8036780
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research Foundation of Korea
ID : 2020R1I1A2074844
Organisme : National Research Foundation of Korea
ID : 2020R1F1A1075509
Organisme : National Research Foundation of Korea
ID : 2017K2A9A2A10013104
Références
Drug Deliv. 2020 Dec;27(1):652-661
pubmed: 32347126
ACS Infect Dis. 2020 May 8;6(5):909-915
pubmed: 32125140
Int J Pharm. 2009 Dec 1;382(1-2):45-9
pubmed: 19666092
Curr Drug Deliv. 2020 Sep 15;:
pubmed: 32938349
Carbohydr Polym. 2019 May 15;212:252-259
pubmed: 30832855
Oncotarget. 2016 Feb 23;7(8):8993-9006
pubmed: 26848771
Chem Asian J. 2015 Oct;10(10):2264-71
pubmed: 25965188
Pharmaceutics. 2021 Jan 14;13(1):
pubmed: 33466598
Int J Nanomedicine. 2020 Nov 11;15:8767-8781
pubmed: 33204087
Adv Pharm Bull. 2015 Sep;5(3):435-41
pubmed: 26504767
Antimicrob Agents Chemother. 2020 May 21;64(6):
pubmed: 32312781
CPT Pharmacometrics Syst Pharmacol. 2021 Feb;10(2):89-99
pubmed: 33296558
Eur J Pharm Sci. 2019 Jul 1;135:91-102
pubmed: 31078644
Biomaterials. 2005 Oct;26(30):6068-76
pubmed: 15894372
Int J Pharm. 2012 Feb 28;423(2):303-11
pubmed: 22155414
Int J Nanomedicine. 2019 Jul 10;14:5051-5060
pubmed: 31371946
J Pharm Sci. 1978 Aug;67(8):1081-7
pubmed: 27625
J Microencapsul. 2018 Aug;35(5):439-453
pubmed: 30289012
Mater Sci Eng C Mater Biol Appl. 2020 May;110:110609
pubmed: 32204060
Chemistry. 2013 Apr 8;19(15):4869-75
pubmed: 23436433
J King Saud Univ Sci. 2021 Mar;33(2):101297
pubmed: 33519145
Lancet. 2020 May 16;395(10236):1569-1578
pubmed: 32423584
Int J Pharm. 2010 Dec 15;402(1-2):117-22
pubmed: 20933070
Drug Resist Updat. 2020 Dec;53:100719
pubmed: 32717568
Int J Pharm. 2021 Mar 15;597:120278
pubmed: 33540007
Eur J Pharmacol. 2021 Apr 5;896:173899
pubmed: 33508281
J Med Virol. 2021 Mar;93(3):1403-1408
pubmed: 32767684
Int J Pharm. 2012 Apr 4;425(1-2):29-34
pubmed: 22266539
Environ Sci Technol. 2010 Oct 15;44(20):7839-45
pubmed: 20866047
Int J Nanomedicine. 2012;7:1635-49
pubmed: 22619517
Nat Commun. 2019 Dec 18;10(1):5770
pubmed: 31852899
Clays Clay Miner. 2016;64(2):115-130
pubmed: 32218609
ACS Appl Mater Interfaces. 2020 Nov 4;12(44):49431-49441
pubmed: 33089977
Med Hypotheses. 2020 Apr 22;140:109765
pubmed: 32361588
Polymers (Basel). 2020 Oct 20;12(10):
pubmed: 33092310
Mol Med Rep. 2020 Oct;22(4):3035-3048
pubmed: 32945405
Polymers (Basel). 2020 Sep 07;12(9):
pubmed: 32906728
Colloids Surf B Biointerfaces. 2021 May;201:111629
pubmed: 33639514
Eur J Pharmacol. 2006 Dec 3;551(1-3):156-61
pubmed: 17027745
J Nanosci Nanotechnol. 2020 Aug 1;20(8):5246-5251
pubmed: 32126726
Life Sci. 2020 Jun 15;251:117627
pubmed: 32251634
Mol Pharm. 2018 Sep 4;15(9):4148-4160
pubmed: 30067372
Biomaterials. 2008 Feb;29(4):475-86
pubmed: 17953985
J Korean Med Sci. 2019 Jan 25;34(5):e37
pubmed: 30718990
R Soc Open Sci. 2017 Nov 8;4(11):170611
pubmed: 29291056
Arch Pharm Res. 2003 Sep;26(9):768-72
pubmed: 14560928
Langmuir. 2010 Apr 20;26(8):5782-90
pubmed: 20235552
J Biomed Mater Res A. 2020 Jan;108(1):30-38
pubmed: 31433913
J Mater Chem B. 2020 Sep 21;8(35):7914-7920
pubmed: 32726382
Eur J Clin Microbiol Infect Dis. 2020 Sep;39(9):1629-1635
pubmed: 32333222
Pharmaceutics. 2020 Sep 17;12(9):
pubmed: 32957491
J Mater Chem B. 2016 Jan 28;4(4):726-742
pubmed: 32262954
Curr Drug Deliv. 2020 Oct 06;:
pubmed: 33023445
Chem Biol Drug Des. 2021 Apr;97(4):836-853
pubmed: 33289334
Acta Biomater. 2011 Aug;7(8):3036-41
pubmed: 21549864