Pathogenic and therapeutic roles of cytokines in acute myeloid leukemia.
Acute myeloid leukemia
Cytokine
Cytokine therapy
Targeted therapy
Therapeutics
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
28
10
2020
revised:
14
03
2021
accepted:
15
03
2021
pubmed:
4
4
2021
medline:
19
1
2022
entrez:
3
4
2021
Statut:
ppublish
Résumé
Acute myeloid leukemia (AML) is a heterogeneous disease with high mortality that accounts for the most common acute leukemia in adults. Despite all progress in the therapeutic strategies and increased rate of complete remission, many patients will eventually relapse and die from the disease. Cytokines as molecular messengers play a pivotal role in the immune system. The imbalance release of cytokine has been shown to exert a significant influence on the progression of hematopoietic malignancies including acute myeloid leukemia. This article aimed to summarize current knowledge about cytokines and their critical roles in the pathogenesis, treatment, and survival of AML patients.
Identifiants
pubmed: 33810945
pii: S1043-4666(21)00088-0
doi: 10.1016/j.cyto.2021.155508
pii:
doi:
Substances chimiques
Cytokines
0
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155508Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.