Vaccines and allergic reactions: The past, the current COVID-19 pandemic, and future perspectives.


Journal

Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028

Informations de publication

Date de publication:
06 2021
Historique:
revised: 23 03 2021
received: 07 02 2021
accepted: 28 03 2021
pubmed: 4 4 2021
medline: 22 6 2021
entrez: 3 4 2021
Statut: ppublish

Résumé

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.

Identifiants

pubmed: 33811364
doi: 10.1111/all.14840
pmc: PMC8251022
doi:

Substances chimiques

COVID-19 Vaccines 0
Vaccines 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1640-1660

Informations de copyright

© 2021 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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Auteurs

Vanitha Sampath (V)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.

Grace Rabinowitz (G)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.

Mihir Shah (M)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.

Surabhi Jain (S)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.

Zuzana Diamant (Z)

Departmentt of Microbiology Immunology & Transplantation, KU Leuven, Catholic University of Leuven, Leuven, Belgium.
Department of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden.
Department of Clinical Pharmacy &Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.

Milos Jesenak (M)

Department of Pediatrics and Department of Clinical Immunology and Allergology, Jessenius Faculty of Medicine in Martin, Center for Vaccination in Special Situations, University Hospital in Martin, Comenius University in Bratislava, Bratislava, Slovakia.

Ronald Rabin (R)

Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

Stefan Vieths (S)

Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.

Ioana Agache (I)

Transylvania University, Brasov, Romania.

Mübeccel Akdis (M)

Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Zurich, Switzerland.

Domingo Barber (D)

Departamento de CienciasMédicasBásicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities, Madrid, España.
Instituto de Salud Carlos III, RETIC ARADYAL, Madrid, Spain.

Heimo Breiteneder (H)

Division of Medical Biotechnology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Sharon Chinthrajah (S)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA, USA.

Tomas Chivato (T)

School of Medicine, University CEU San Pablo, Madrid, Spain.

William Collins (W)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.
Department of Medicine, Division of Hospital Medicine, Stanford University, Stanford, CA, USA.

Thomas Eiwegger (T)

Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Toronto, ON, Canada.
Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Immunology, University of Toronto, Toronto, ON, Canada.

Katharine Fast (K)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.

Wytske Fokkens (W)

Department of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Robyn E O'Hehir (RE)

Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, and Alfred Health, Melbourne, Vic, Australia.

Markus Ollert (M)

Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, Odense University Hospital, University of Southern Denmark, Odense, Denmark.

Liam O'Mahony (L)

Department of Medicine and School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.

Oscar Palomares (O)

Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University, Madrid, Spain.

Oliver Pfaar (O)

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.

Carmen Riggioni (C)

Department of Paediatrics, Allergy and Clinical Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

Mohamed H Shamji (MH)

Department of National Heart and Lung Institute, Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Imperial College London, London, UK.
Centre in Allergic Mechanisms of Asthma, London, UK.

Milena Sokolowska (M)

Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Zurich, Switzerland.

Maria Jose Torres (M)

Allergy Unit, Malaga Regional University Hospital-UMA-ARADyAL, Málaga, Spain.

Claudia Traidl-Hoffmann (C)

Department of Environmental Medicine, Medical Faculty, University Augsburg, Augsburg, Germany.
Institute of Environmental Medicine, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.

Menno van Zelm (M)

Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia.
Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, VIC, Australia.

De Yun Wang (Y)

Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Luo Zhang (L)

Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Cezmi A Akdis (CA)

Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Zurich, Switzerland.

Kari C Nadeau (KC)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA, USA.
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA, USA.

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