Luminescent lanthanide complexes for reactive oxygen species biosensing and possible application in Alzheimer's diseases.
amyloid-beta peptide
biomolecules
lanthanide
luminescence
oxidative stress
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
19
02
2021
received:
14
12
2020
accepted:
01
04
2021
pubmed:
4
4
2021
medline:
6
5
2022
entrez:
3
4
2021
Statut:
ppublish
Résumé
Histopathological hallmarks of Alzheimer's disease (AD) are intracellular neurofibrillary tangles and extracellular formation of senile plaques composed of the aggregated amyloid-beta peptide along with metal ions (copper, iron or zinc). In addition, oxidative stress is considered as an important factor in the etiology of AD and a multitude of metalloproteins and transporters is affected, leading to metal ion misregulation. Redox-active metal ions (e.g., copper) can catalyze the production of reactive oxygen species (ROS) in the presence of molecular oxygen and a reductant such as ascorbate. The ROS thus produced, in particular the hydroxyl radical which is the most reactive one, may contribute to oxidative stress conditions. Thus, detecting ROS in vivo or in biological models of AD is of interest for better understanding AD etiology. The use of biocompatible and highly specific and sensitive probes is needed for such a purpose, since ROS are transient species whose steady-state concentrations are very low. Luminescent lanthanide complexes are sensitive probes that can meet these criteria. The present review focuses on the recent advances in the use of luminescent lanthanide complexes for ROS biosensing. It shows why the use of luminescent lanthanide complexes is of particular interest for selectively detecting ROS (
Substances chimiques
Amyloid beta-Peptides
0
Lanthanoid Series Elements
0
Reactive Oxygen Species
0
Copper
789U1901C5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2516-2539Informations de copyright
© 2021 Federation of European Biochemical Societies.
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