Are the oxidative stress levels in the tumor center and tumor boundary different from those in healthy tissue?
Cancer
Head and neck
Localization
Oxidative stress
Tumor
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
17
11
2020
accepted:
11
03
2021
pubmed:
4
4
2021
medline:
3
11
2021
entrez:
3
4
2021
Statut:
ppublish
Résumé
This study aimed to investigate the relationship between oxidative stress levels in the tumor center, tumor edge, and healthy tissue. This study included a total of 53 patients with head and neck cancer. Samples of 5 × 5 × 5 mm were collected from the tumor center, tumor edge, and the healthy tissue. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were evaluated. (1) Oxidative stress values in the center and edge of all tumors and in healthy tissues were compared according to localization. (2) Tumors were divided into two groups as malignant (Group 1 [n = 28]: Laryngeal and tongue squamous cell cancers) and benign (Group 2 [n = 25]: Pleomorphic adenoma and Warthin tumors). The groups were compared according to the localization of the tissues. The TOS value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue. The TAS value in tissue located in the tumor edge was significantly higher than in the healthy tissue. The OSI value in the tumor edge was significantly higher than those in the tumor center and the healthy tissue. In all three localizations (tumor center, tumor edge, and healthy tissue), TOS and OSI values in Group 1 were significantly higher than Group 2. Oxidative stress values in the tumor edge are significantly higher than the center of the tumor and healthy tissue. In malignant tumors, oxidative stress values are significantly higher in all localizations compared to benign tumors.
Identifiants
pubmed: 33811549
doi: 10.1007/s00405-021-06749-x
pii: 10.1007/s00405-021-06749-x
doi:
Substances chimiques
Antioxidants
0
Oxidants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5013-5020Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Yang J, Lam EW, Hammad HM et al (2002) Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium. J Oral Pathol Med 31:71–77
doi: 10.1034/j.1600-0714.2002.310202.x
Kubica K, Rogoziński P, Bruliński K (2019) Activity of Antioxidant Enzymes in the Tumor and Adjacent Noncancerous Tissues of Non-Small-Cell Lung Cancer. Oxid Med Cell Longev 2019:2901840. https://doi.org/10.1155/2019/2901840
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 49(11):1603–1616
doi: 10.1016/j.freeradbiomed.2010.09.006
Gaya-Bover A, Hernández-López R, Alorda-Clara M et al (2020) Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer. Int J Biochem Cell Biol 120:105698
doi: 10.1016/j.biocel.2020.105698
Dogan R, Meriç Hafiz A, Tugrul S, Ozturan O, Keskin S, Kocyigit A (2016) Can oxidative stress parameters be used as biomarkers for the discrimination of malignant head and neck tumors. J Craniofac Surg 27(3):316–320
doi: 10.1097/SCS.0000000000002575
Gokul S, Patil VS, Jailkhani R et al (2010) Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients. Oral Dis 16:29–33
doi: 10.1111/j.1601-0825.2009.01598.x
Corsi MM, Pagani D, Iorio EL, Dogliotti G, Verna R, Sambataro G (2006) Blood reactive oxygen metabolites (ROMs) and total antioxidant status (TAS) in patients with laryngeal squamous cell carcinoma after surgical treatment. Clin Chem Lab Med 44(8):1047–1048
doi: 10.1515/CCLM.2006.181
Hartree EF (1972) Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem 48(2):422–427
doi: 10.1016/0003-2697(72)90094-2
Erel O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38(12):1103–1111
doi: 10.1016/j.clinbiochem.2005.08.008
Erel O (2004) A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 37(2):112–119
doi: 10.1016/j.clinbiochem.2003.10.014
Mantovani G, Macciò A, Lai P, Massa M, Ghiani M, Santona MC (1998) Cytokine activity in cancer-related anorexia/ cachexia: role of megestrol acetate and medroxyprogesterone acetate. Semin Oncol 25:45–52
pubmed: 9625383
Pelicano H, Carney D, Huang P (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist Update 7:97–110
doi: 10.1016/j.drup.2004.01.004
Mantovani G, Macciò A, Madeddu C, Mura L, Massa E, Gramignano G et al (2002) Reactive oxygen species, antioxidant mechanisms and serum cytokine levels in cancer patients: impact of an antioxidant treatment. J Cell Mol Med 6:570–582
doi: 10.1111/j.1582-4934.2002.tb00455.x
Egeblad M, Nakasone ES, Werb Z (2010) Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 18:884–901
doi: 10.1016/j.devcel.2010.05.012
Chung-man Ho J, Zheng S, Comhair SA, Farver C, Erzurum SC (2001) Differential expression of manganese superoxide dismutase and catalase in lung cancer. Cancer Res 61(23):8578–8585
pubmed: 11731445
Santandreu FM, Brell M, Gene AH et al (2008) Differences in mitochondrial function and antioxidant systems between regions of human glioma. Cell Physiol Biochem 22(5–6):757–768
doi: 10.1159/000185559
Chowdhury FN, Reisinger J, Gomez KE, Chimed TS, Thomas CM, Le PN (2019) Leading edge or tumor core: intratumor cancer stem cell niches in oral cavity squamous cell carcinoma and their association with stem cell function. Oral Oncol 98:118–124
doi: 10.1016/j.oraloncology.2019.09.011
Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454(7203):436–444
doi: 10.1038/nature07205
Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883–899
doi: 10.1016/j.cell.2010.01.025
Hinni ML, Ferlito A, Brandwein-Gensler MS, Takes RP, Silver CE, Westra WH et al (2012) Surgical margins in head and neck cancer: a contemporary review. Head Neck 35:1362–1370
doi: 10.1002/hed.23110
Melo SA, Sugimoto H, O’Connell JT et al (2014) Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 26(5):707–721
doi: 10.1016/j.ccell.2014.09.005
Guo W, Gao Y, Li N et al (2017) Exosomes: new players in cancer (review). Oncol Rep 38(2):665–675
doi: 10.3892/or.2017.5714
Srivastava KC, Austin RD, Shrivastava D, Sethupathy S, Rajesh S (2012) A case control study to evaluate oxidative stress in plasma samples of oral malignancy. Contemp Clin Dent 3(3):271–276
doi: 10.4103/0976-237X.103617
Yun M, Choi AJ, Lee YC, Kong M, Sung JY, Kim SS et al (2018) Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma. J Exp Clin Cancer Res 37(1):264
doi: 10.1186/s13046-018-0942-9
Conklin KA (2004) Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther 3(4):294–300
doi: 10.1177/1534735404270335
Kotamraju S, Chitambar CR, Kalivendi SV, Joseph J, Kalyanaraman B (2002) Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells role of oxidant-induced iron signaling in apoptosis. J Biol Chem 277(19):17179–17187
doi: 10.1074/jbc.M111604200
Zou Z, Chang H, Li H, Wang S (2017) Induction of reactive oxygen species: an emerging approach for cancer therapy. Apoptosis 22(11):1–15
doi: 10.1007/s10495-017-1424-9
Li S, Chou AP, Chen W, Chen R, Deng Y, Phillips HS et al (2012) Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation. Neuro Oncol 15(1):57–68
doi: 10.1093/neuonc/nos261
Pacor S, Zorzet S, Cocchietto M, Bacac M, Vadori M, Turrin C (2004) Intratumoral NAMI-A treatment triggers metastasis reduction, which correlates to CD44 regulation and tumor infiltrating lymphocyte recruitment. J Pharmacol Exp Ther 310(2):737–744
doi: 10.1124/jpet.104.066175
Gillberg L, Ørskov AD, Liu M, Harsløf LBS, Jones PA, Grønbæk K (2018) Vitamin C—a new player in regulation of the cancer epigenome. Semin Cancer Biol 51:59–67
doi: 10.1016/j.semcancer.2017.11.001
Voth BL, Pelargos PE, Barnette NE et al (2020) Intratumor injection of CCL21-coupled vault nanoparticles is associated with reduction in tumor volume in an in vivo model of glioma. J Neurooncol 147(3):599–605
doi: 10.1007/s11060-020-03479-8
Singh P, Anil G (2013) Yttrium-90 radioembolization of liver tumors: what do the images tell us? Cancer Imaging 13(4):645–657
doi: 10.1102/1470-7330.2013.0057