Immunomodulation by epigenome alterations in Mycobacterium tuberculosis infection.
DNA methylation
Epigenetics
Histone modification
Immunomodulation
MicroRNAs
Mycobacterium tuberculosis
Journal
Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
29
10
2020
revised:
24
02
2021
accepted:
07
03
2021
pubmed:
4
4
2021
medline:
8
1
2022
entrez:
3
4
2021
Statut:
ppublish
Résumé
Mycobacterium tuberculosis (MTB) has co-evolved with humans for decades and developed several mechanisms to evade host immunity. It can efficiently alter the host epigenome, thus playing a major role in immunomodulation by either activating or suppressing genes responsible for mounting an immune response against the pathogen. Epigenetic modifications such as DNA methylation and chromatin remodelling regulate gene expression and influence several cellular processes. The involvement of epigenetic factors in disease onset and development had been overlooked upon in comparison to genetic mutations. It is now believed that assessment of epigenetic changes hold great potential in diagnosis, prevention and treatment strategies for a wide range of diseases. In this review, we unravel the principles of epigenetics and the numerous ways by which MTB re-shapes the host epigenetic landscape as a strategy to overpower the host immune system for its survival and persistence.
Identifiants
pubmed: 33812175
pii: S1472-9792(21)00027-5
doi: 10.1016/j.tube.2021.102077
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102077Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.