Bioengineered percutaneous heart valves for transcatheter aortic valve replacement: a comparative evaluation of decellularised bovine and porcine pericardia.

Animals Bioprosthesis Cattle Heart Valve Prosthesis Heart Valves Materials Testing Swine Transcatheter Aortic Valve Replacement
Biomaterials Heart valve degeneration ISO standards Novel devices TAVI/TAVR

Journal

Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 20 12 2019
revised: 06 08 2020
accepted: 31 01 2021
entrez: 4 4 2021
pubmed: 5 4 2021
medline: 15 5 2021
Statut: ppublish

Résumé

Glutaraldehyde-treated, surgical bioprosthetic heart valves undergo structural degeneration within 10-15 years of implantation. Analogous preliminary results were disclosed for percutaneous heart valves (PHVs) realized with similarly-treated tissues. To improve long-term performance, decellularised scaffolds can be proposed as alternative fabricating biomaterials. The aim of this study was to evaluate whether bovine and porcine decellularised pericardia could be utilised to manufacture bioengineered percutaneous heart valves (bioPHVs) with adequate hydrodynamic performance and leaflet resistance to crimping damage. BioPHVs were fabricated by mounting acellular pericardia onto commercial stents. Independently from the pericardial species used for valve fabrication, bioPHVs satisfied the minimum hydrodynamic performance criteria set by ISO 5840-3 standards and were able to withstand a large spectrum of cardiac output conditions, also during extreme backpressure, without severe regurgitation, especially in the case of the porcine group. No macroscopic or microscopic leaflet damage was detected following bioPHV crimping. Bovine and porcine decellularized pericardia are both suitable alternatives to glutaraldehyde-treated tissues. Between the two types of pericardial species tested, the porcine tissue scaffold might be preferable to fabricate advanced PHV replacements for long-term performance. CONDENSED ABSTRACT: Current percutaneous heart valve replacements are formulated with glutaraldehyde-treated animal tissues, prone to structural degeneration. In order to improve long-term performance, bovine and porcine decellularised pericardia were utilised to manufacture bioengineered replacements, which demonstrated adequate hydrodynamic behaviour and resistance to crimping without leaflet architectural alteration.

Identifiants

DOI: 10.1016/j.msec.2021.111936 PMID: 33812574
pubmed: 33812574
pii: S0928-4931(21)00074-6
doi: 10.1016/j.msec.2021.111936
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111936

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Sugat Ratna Tuladhar (SR)

Cardiovascular Regenerative Medicine, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Shane Mulderrig (S)

Department of Biohybrid & Medical Textiles (BioTex), Institute for Applied Medical Engineering, Helmholtz Aachen, University Hospital RWTH Aachen, Aachen, Germany.

Mila Della Barbera (M)

Cardiovascular Pathology, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Luca Vedovelli (L)

Biostatistics, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Daniele Bottigliengo (D)

Biostatistics, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Chiara Tessari (C)

Cardiovascular Regenerative Medicine, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Stefan Jockenhoevel (S)

Department of Biohybrid & Medical Textiles (BioTex), Institute for Applied Medical Engineering, Helmholtz Aachen, University Hospital RWTH Aachen, Aachen, Germany.

Dario Gregori (D)

Biostatistics, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Gaetano Thiene (G)

Cardiovascular Pathology, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Sotiris Korossis (S)

Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, Hannover Medical School, Hannover, Germany.

Petra Mela (P)

Department of Biohybrid & Medical Textiles (BioTex), Institute for Applied Medical Engineering, Helmholtz Aachen, University Hospital RWTH Aachen, Aachen, Germany.

Laura Iop (L)

Cardiovascular Regenerative Medicine, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy; L.I.F.E.LA.B., CORIS, Veneto Region, Padua, Italy.

Gino Gerosa (G)

Cardiovascular Regenerative Medicine, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy; L.I.F.E.LA.B., CORIS, Veneto Region, Padua, Italy. Electronic address: gino.gerosa@unipd.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bioengineered percutaneous heart valves for...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Bioprothèse › Bioengineered percutaneous heart valves for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Bioengineered percutaneous heart valves for...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Prothèse valvulaire cardiaque › Bioengineered percutaneous heart valves for...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Valves cardiaques › Bioengineered percutaneous heart valves for...
questionsmedicales.fr › Techniques d'investigation › Test de matériaux › Bioengineered percutaneous heart valves for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Bioengineered percutaneous heart valves for...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie thoracique › Procédures de chirurgie cardiaque › Implantation de valve prothétique cardiaque › Remplacement valvulaire aortique par cathéter › Bioengineered percutaneous heart valves for...