Electrically-responsive antimicrobial coatings based on a tetracycline-loaded poly(3,4-ethylenedioxythiophene) matrix.
Antimicrobial activity
Bacterial growth
Conjugated polymers
Escherichia coli
Poly(3,4-ethylenedioxythiophene)
Tetracycline
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
13
12
2020
revised:
09
02
2021
accepted:
02
03
2021
entrez:
4
4
2021
pubmed:
5
4
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
The growth of bacteria and the formation of complex bacterial structures on biomedical devices is a major challenge in modern medicine. The aim of this study was to develop a biocompatible, conducting and antibacterial polymer coating applicable in biomedical engineering. Since conjugated polymers have recently aroused strong interest as controlled delivery systems for biologically active compounds, we decided to employ a poly(3,4-ethylenedioxythiophene) (PEDOT) matrix to immobilize a powerful, first-line antibiotic: tetracycline (Tc). Drug immobilization was carried out simultaneously with the electrochemical polymerization process, allowing to obtain a polymer coating with good electrochemical behaviour (charge storage capacity of 19.15 ± 6.09 mC/cm
Identifiants
pubmed: 33812635
pii: S0928-4931(21)00156-9
doi: 10.1016/j.msec.2021.112017
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Bridged Bicyclo Compounds, Heterocyclic
0
Polymers
0
poly(3,4-ethylene dioxythiophene)
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112017Informations de copyright
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