Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge.
Animal model
COVID-19
Clinical trial
Pandemic
Pre-clinical research
Vaccine
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
19
12
2020
revised:
22
02
2021
accepted:
05
03
2021
pubmed:
5
4
2021
medline:
18
5
2021
entrez:
4
4
2021
Statut:
ppublish
Résumé
Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.
Identifiants
pubmed: 33813139
pii: S2352-3964(21)00084-0
doi: 10.1016/j.ebiom.2021.103291
pmc: PMC8016444
pii:
doi:
Substances chimiques
Antiviral Agents
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103291Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflicts of interest.
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