Bioinspired imidazo[1,2-a:4,5-c']dipyridines with dual antiproliferative and anti-migrative properties in human cancer cells: The SAR investigation.
Antineoplastic Agents
/ chemical synthesis
Apoptosis
/ drug effects
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Structure-Activity Relationship
Tumor Cells, Cultured
Anti-migration activity
Antiproliferative activity
Harmine analogues
Imidazo[1,2-a:4,5-c’]dipyridines
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Jun 2021
05 Jun 2021
Historique:
received:
10
11
2020
revised:
28
01
2021
accepted:
30
01
2021
pubmed:
5
4
2021
medline:
7
8
2021
entrez:
4
4
2021
Statut:
ppublish
Résumé
Herein, we report the design, synthesis and evaluation of novel bioinspired imidazo[1,2-a:4,5c']dipyridines. The structural optimization identified four anti-proliferative compounds. Compounds 11, 18, 19 and 20 exhibited excellent anticancer activities in vitro with IC
Identifiants
pubmed: 33813152
pii: S0223-5234(21)00107-0
doi: 10.1016/j.ejmech.2021.113258
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113258Informations de copyright
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.