Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors.

Adult Atherosclerosis Computed Tomography Angiography Coronary Angiography Coronary Artery Disease / diagnostic imaging Female Humans Male Plaque, Atherosclerotic Risk Factors

Atherogenic index of plasma Atherosclerosis Coronary artery disease Coronary computed tomography angiography

Journal

Atherosclerosis

ISSN: 1879-1484

Titre abrégé: Atherosclerosis

Pays: Ireland

ID NLM: 0242543

Informations de publication

Date de publication:
05 2021

Historique:

received: 03 12 2020

revised: 03 03 2021

accepted: 10 03 2021

pubmed: 5 4 2021

medline: 24 6 2021

entrez: 4 4 2021

Statut: ppublish

Résumé

The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) ≥1.0%/year. All participants were divided into three groups based on AIP tertiles. Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV. Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.

Sections du résumé

BACKGROUND AND AIMS

METHODS

A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) ≥1.0%/year. All participants were divided into three groups based on AIP tertiles.

RESULTS

Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV.

CONCLUSIONS

Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.

Identifiants

DOI: 10.1016/j.atherosclerosis.2021.03.009 PMID: 33813155

pubmed: 33813155

pii: S0021-9150(21)00117-9

doi: 10.1016/j.atherosclerosis.2021.03.009

pii:

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

46-51

Commentaires et corrections

Type : CommentIn