Adaptive Remodeling in the Elastase-induced Rabbit Aneurysms.
animal model
axial loading
cerebral aneurysm
collagen remodeling
constitutive modeling
Journal
Experimental mechanics
ISSN: 0014-4851
Titre abrégé: Exp Mech
Pays: United States
ID NLM: 101469718
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
entrez:
5
4
2021
pubmed:
6
4
2021
medline:
6
4
2021
Statut:
ppublish
Résumé
Rupture of brain aneurysms is associated with high fatality and morbidity rates. Through remodeling of the collagen matrix, many aneurysms can remain unruptured for decades, despite an enlarging and evolving geometry. Our objective was to explore this adaptive remodeling for the first time in an elastase induced aneurysm model in rabbits. Saccular aneurysms were created in 22 New Zealand white rabbits and remodeling was assessed in tissue harvested 2, 4, 8 and 12 weeks after creation. The intramural principal stress ratio doubled after aneurysm creation due to increased longitudinal loads, triggering a remodeling response. A distinct wall layer with multi-directional collagen fibers developed between the media and adventitia as early as 2 weeks, and in all cases by 4 weeks with an average thickness of 50.6 ± 14.3 μm. Collagen fibers in this layer were multi-directional ( A new mechanism was identified by which aneurysm walls can rapidly adapt to changes in load, ensuring the structural integrity of the aneurysm until a slower process of medial reorganization occurs. The rabbit model can be used to evaluate therapies to increase aneurysm wall stability.
Sections du résumé
BACKGROUND
BACKGROUND
Rupture of brain aneurysms is associated with high fatality and morbidity rates. Through remodeling of the collagen matrix, many aneurysms can remain unruptured for decades, despite an enlarging and evolving geometry.
OBJECTIVE
OBJECTIVE
Our objective was to explore this adaptive remodeling for the first time in an elastase induced aneurysm model in rabbits.
METHODS
METHODS
Saccular aneurysms were created in 22 New Zealand white rabbits and remodeling was assessed in tissue harvested 2, 4, 8 and 12 weeks after creation.
RESULTS
RESULTS
The intramural principal stress ratio doubled after aneurysm creation due to increased longitudinal loads, triggering a remodeling response. A distinct wall layer with multi-directional collagen fibers developed between the media and adventitia as early as 2 weeks, and in all cases by 4 weeks with an average thickness of 50.6 ± 14.3 μm. Collagen fibers in this layer were multi-directional (
CONCLUSIONS
CONCLUSIONS
A new mechanism was identified by which aneurysm walls can rapidly adapt to changes in load, ensuring the structural integrity of the aneurysm until a slower process of medial reorganization occurs. The rabbit model can be used to evaluate therapies to increase aneurysm wall stability.
Identifiants
pubmed: 33814553
doi: 10.1007/s11340-020-00671-9
pmc: PMC8011419
mid: NIHMS1641676
doi:
Types de publication
Journal Article
Langues
eng
Pagination
263-283Subventions
Organisme : NINDS NIH HHS
ID : R01 NS097457
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS088256
Pays : United States
Organisme : NIH HHS
ID : S10 OD025041
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interst: The authors declare no competing interests.
Références
World Neurosurg. 2018 Sep;117:453-458.e1
pubmed: 29902602
Biomech Model Mechanobiol. 2011 Feb;10(1):109-32
pubmed: 20496095
Ann Biomed Eng. 2013 Jul;41(7):1528-38
pubmed: 23297000
J Neurointerv Surg. 2019 Nov;11(11):1150-1154
pubmed: 31036558
Sci Rep. 2019 Nov 1;9(1):15865
pubmed: 31676797
Neurosurgery. 2020 Jan 1;86(Suppl 1):S13-S19
pubmed: 31838528
Coll Relat Res. 1985 Dec;5(6):481-92
pubmed: 3833451
Am J Physiol. 1989 Apr;256(4 Pt 2):H931-9
pubmed: 2705563
IEEE Trans Med Imaging. 2005 Apr;24(4):457-67
pubmed: 15822804
J Mech Behav Biomed Mater. 2018 Jan;77:475-484
pubmed: 29032314
Cerebrovasc Dis. 2019;48(1-2):26-31
pubmed: 31473731
AJR Am J Roentgenol. 2000 Feb;174(2):349-54
pubmed: 10658703
AJNR Am J Neuroradiol. 2014 Jul;35(7):1358-62
pubmed: 24557706
J Neuroradiol. 2019 Feb;46(1):25-28
pubmed: 30389508
Circ Res. 2002 May 3;90(8):918-25
pubmed: 11988494
Ann Biomed Eng. 2013 Jul;41(7):1366-83
pubmed: 23242844
Ann Biomed Eng. 2015 Jul;43(7):1502-15
pubmed: 25632891
J Biomed Mater Res A. 2009 Feb;88(2):322-31
pubmed: 18286605
J Biomech. 2007;40(4):766-76
pubmed: 16750537
Acta Neurochir (Wien). 2020 Mar;162(3):553-566
pubmed: 32008209
Neurosurgery. 2005 Oct;57(4):676-83; discussion 676-83
pubmed: 16239879
Jpn Circ J. 1994 Apr;58(4):264-8
pubmed: 8051785
Stroke. 2011 Jul;42(7):1878-82
pubmed: 21546472
Neurosurg Focus. 2009 May;26(5):E2
pubmed: 19408998
J Neurosurg. 2008 May;108(5):1052-60
pubmed: 18447733
J Biomech Eng. 2018 Jun 1;140(6):
pubmed: 29560496
Opt Express. 2005 Apr 4;13(7):2337-44
pubmed: 19495122
Math Med Biol. 2009 Jun;26(2):133-64
pubmed: 19234094
Radiology. 2013 Oct;269(1):258-65
pubmed: 23821755
Methods Mol Biol. 2017;1627:429-451
pubmed: 28836218
J Neurosurg. 2005 Feb;102(2):355-62
pubmed: 15739566
J Surg Res. 2007 May 15;139(2):236-42
pubmed: 17303171
J Biomech Eng. 2012 Jan;134(1):011005
pubmed: 22482660
Stroke. 2017 Jul;48(7):1986-1989
pubmed: 28468927
Stroke. 2019 Jun;50(6):1570-1573
pubmed: 31035900
Neurol Res. 1990 Dec;12(4):249-55
pubmed: 1982169
J Biomech. 2012 Mar 15;45(5):762-71
pubmed: 22305290
J Biomech. 2006;39(16):3010-6
pubmed: 16337949
AJNR Am J Neuroradiol. 2015 May;36(5):953-9
pubmed: 25655875
Radiology. 2012 Jun;263(3):828-35
pubmed: 22623696
J Biomech Eng. 2006 Feb;128(1):142-9
pubmed: 16532628
Biomech Model Mechanobiol. 2018 Apr;17(2):403-417
pubmed: 29039043
Ann Biomed Eng. 2013 Jul;41(7):1505-15
pubmed: 23392863
Biomech Model Mechanobiol. 2018 Dec;17(6):1757-1769
pubmed: 30058051
J R Soc Interface. 2012 Nov 7;9(76):3081-93
pubmed: 22764133
Neuroradiology. 2019 Mar;61(3):275-284
pubmed: 30456458
J Biomed Opt. 2014 Jan;19(1):16007
pubmed: 24407500
Front Surg. 2016 Jul 25;3:43
pubmed: 27504449
Tissue Eng Part A. 2015 May;21(9-10):1529-38
pubmed: 25710791
Arch Neurol. 1963 Mar;8:272-85
pubmed: 13983641
J Neurointerv Surg. 2018 Apr;10(4):411-415
pubmed: 28768819
J Neurointerv Surg. 2017 Oct;9(10):994-998
pubmed: 27707872
Stroke. 2007 Aug;38(8):2346-52
pubmed: 17615366
AJNR Am J Neuroradiol. 2017 Jan;38(1):119-126
pubmed: 27686488
Expert Rev Med Devices. 2010 Nov;7(6):825-42
pubmed: 21050092
AJNR Am J Neuroradiol. 2015 Sep;36(9):1695-703
pubmed: 26228891
Biomech Model Mechanobiol. 2005 Dec;4(4):235-48
pubmed: 16283226
AJNR Am J Neuroradiol. 2011 Mar;32(3):595-601
pubmed: 21273353
J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):42-8
pubmed: 23012447