Heat Shock Proteins in Lymphoma Immunotherapy.
Animals
Benzamides
/ therapeutic use
Benzodioxoles
/ therapeutic use
Glycine
/ therapeutic use
Heat-Shock Proteins
/ antagonists & inhibitors
Humans
Immunotherapy
/ methods
Immunotherapy, Adoptive
/ methods
Indazoles
/ therapeutic use
Isoxazoles
/ therapeutic use
Lymphoma
/ immunology
Molecular Targeted Therapy
/ methods
Purines
/ therapeutic use
Resorcinols
/ therapeutic use
CAR NK
CAR T
checkpoint inhibitors
heat shock proteins
lymphoma
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
01
2021
accepted:
26
02
2021
entrez:
5
4
2021
pubmed:
6
4
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Immunotherapy harnessing the host immune system for tumor destruction revolutionized oncology research and advanced treatment strategies for lymphoma patients. Lymphoma is a heterogeneous group of cancer, where the central roles in pathogenesis play immune evasion and dysregulation of multiple signaling pathways. Immunotherapy-based approaches such as engineered T cells (CAR T), immune checkpoint modulators and NK cell-based therapies are now in the frontline of lymphoma research. Even though emerging immunotherapies showed promising results in treating lymphoma patients, low efficacy and on-target/off-tumor toxicity are of a major concern. To address that issue it is suggested to look into the emerging role of heat shock proteins. Heat shock proteins (HSPs) showed to be highly expressed in lymphoma cells. HSPs are known for their abilities to modulate immune responses and inhibit apoptosis, which made their successful entry into cancer clinical trials. Here, we explore the role of HSPs in Hodgkin and Non-Hodgkin lymphoma and their involvement in CAR T therapy, checkpoint blockade and NK cell- based therapies. Understanding the role of HSPs in lymphoma pathogenesis and the ways how HSPs may enhance anti-tumor responses, may help in the development of more effective, specific and safe immunotherapy.
Identifiants
pubmed: 33815422
doi: 10.3389/fimmu.2021.660085
pmc: PMC8012763
doi:
Substances chimiques
5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide
0
Benzamides
0
Benzodioxoles
0
Heat-Shock Proteins
0
Indazoles
0
Isoxazoles
0
Purines
0
Resorcinols
0
9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)-
06IVK87M04
SNX-5422
BF52J69Q8T
Glycine
TE7660XO1C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
660085Informations de copyright
Copyright © 2021 Albakova, Mangasarova and Sapozhnikov.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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