Familial-Related Risks for Congenital Hypothyroidism in Iranian Newborns: A Population-Based Case-Control Study.
Congenital Hypothyroidism
Familial Risk Factor
Intra-family Marriage
Newborn Screening Program
Population Attributable Fraction
Journal
International journal of endocrinology and metabolism
ISSN: 1726-913X
Titre abrégé: Int J Endocrinol Metab
Pays: Netherlands
ID NLM: 101235597
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
12
05
2020
revised:
19
11
2020
accepted:
23
12
2020
entrez:
5
4
2021
pubmed:
6
4
2021
medline:
6
4
2021
Statut:
epublish
Résumé
Congenital hypothyroidism (CH), as one of the most common endocrine disorders, is a preventable cause of mental retardation. This study aimed to identify familial-related risk factors for CH in Iranian newborns. A population-based case-control study was performed on the National Registry System of patients with CH in Iran. In this study, 906 controls and 454 cases were studied for one year. Familial related factors were investigated using logistic regression models. Population attributable fraction (PAF) was also calculated for each significant risk factor. Using multivariate analysis, an increased risk for CH was observed in patients with congenital anomalies (odds ratio (OR): 5.77, 95% confidence interval (CI): 2.37 - 14.01), history of mental retardation in family (OR:2.10, 95% CI: 1.15-3.83), mother's hypothyroidism during pregnancy (OR: 2.01, 95% CI: 1.33 - 3.03), intra-family marriage (OR:1.49, 95% CI: 1.18 - 1.89), gestational diabetes (OR: 1.69, 95% CI: 1.09 - 2.63), having a hypothyroid child in the family (OR: 2.48, 95% CI: 1.39 - 4.42), and twins or more (OR: 2.61, 95% CI: 1.31 - 5.21). The highest PAF among familial-related risk factors for CH is related to the intra-family marriage (14.9%). This study revealed that familial-related risk factors and consanguine marriages play an essential role in the high incidence of CH in Iran. About 15% of CH in Iran could be attributed to intra-family marriage alone.
Sections du résumé
BACKGROUND
BACKGROUND
Congenital hypothyroidism (CH), as one of the most common endocrine disorders, is a preventable cause of mental retardation.
OBJECTIVE
OBJECTIVE
This study aimed to identify familial-related risk factors for CH in Iranian newborns.
METHODS
METHODS
A population-based case-control study was performed on the National Registry System of patients with CH in Iran. In this study, 906 controls and 454 cases were studied for one year. Familial related factors were investigated using logistic regression models. Population attributable fraction (PAF) was also calculated for each significant risk factor.
RESULTS
RESULTS
Using multivariate analysis, an increased risk for CH was observed in patients with congenital anomalies (odds ratio (OR): 5.77, 95% confidence interval (CI): 2.37 - 14.01), history of mental retardation in family (OR:2.10, 95% CI: 1.15-3.83), mother's hypothyroidism during pregnancy (OR: 2.01, 95% CI: 1.33 - 3.03), intra-family marriage (OR:1.49, 95% CI: 1.18 - 1.89), gestational diabetes (OR: 1.69, 95% CI: 1.09 - 2.63), having a hypothyroid child in the family (OR: 2.48, 95% CI: 1.39 - 4.42), and twins or more (OR: 2.61, 95% CI: 1.31 - 5.21). The highest PAF among familial-related risk factors for CH is related to the intra-family marriage (14.9%).
CONCLUSIONS
CONCLUSIONS
This study revealed that familial-related risk factors and consanguine marriages play an essential role in the high incidence of CH in Iran. About 15% of CH in Iran could be attributed to intra-family marriage alone.
Identifiants
pubmed: 33815515
doi: 10.5812/ijem.104889
pmc: PMC8010566
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e104889Informations de copyright
Copyright © 2021, International Journal of Endocrinology and Metabolism.
Déclaration de conflit d'intérêts
Conflict of Interests: No potential conflict of interest was reported by the authors.
Références
Curr Opin Endocrinol Diabetes Obes. 2015 Oct;22(5):407-12
pubmed: 26313902
Pediatr Int. 2010 Jun;52(3):467-71
pubmed: 20003140
J Pediatr Endocrinol Metab. 2008 Oct;21(10):1011-20
pubmed: 19209623
Horm Res Paediatr. 2015;83(2):79-85
pubmed: 25277881
Indian Pediatr. 2018 Feb 15;55(2):121-124
pubmed: 28952455
J Pediatr Endocrinol Metab. 2010 Aug;23(8):815-26
pubmed: 21073124
Nutrients. 2017 Oct 30;9(11):
pubmed: 29084139
J Clin Endocrinol Metab. 2007 Aug;92(8):3141-7
pubmed: 17488789
Int J Endocrinol Metab. 2017 Jun 25;15(3):e55451
pubmed: 29201074
J Community Genet. 2012 Jan;3(1):35-45
pubmed: 22271560
East Mediterr Health J. 2007 May-Jun;13(3):567-74
pubmed: 17687829
Rev Paul Pediatr. 2019 Jan-Mar;37(1):82-89
pubmed: 30183803
J Clin Endocrinol Metab. 2002 Sep;87(9):4072-7
pubmed: 12213848
Orphanet J Rare Dis. 2010 Jun 10;5:17
pubmed: 20537182
Endocrinology. 2002 Jun;143(6):2019-24
pubmed: 12021164
Int J Pediatr Endocrinol. 2017;2017:11
pubmed: 29026407
Int J Endocrinol Metab. 2020 Apr 27;18(2):e99099
pubmed: 32636885
Horm Res Paediatr. 2014;81(2):80-103
pubmed: 24662106
Iran Red Crescent Med J. 2016 Aug 07;18(11):e22038
pubmed: 28191326
Arch Dis Child Fetal Neonatal Ed. 2019 Mar;104(2):F176-F181
pubmed: 29540462
Eur J Endocrinol. 2005 Dec;153(6):765-73
pubmed: 16322381
Data Brief. 2018 Nov 27;21:2510-2514
pubmed: 30560160