Idarucizumab (Praxbind
direct oral anticoagulant (DOAC) dabigatran
heart transplantation
idarucizumab
Journal
Future science OA
ISSN: 2056-5623
Titre abrégé: Future Sci OA
Pays: England
ID NLM: 101665030
Informations de publication
Date de publication:
15 Feb 2021
15 Feb 2021
Historique:
entrez:
5
4
2021
pubmed:
6
4
2021
medline:
6
4
2021
Statut:
epublish
Résumé
Novel oral anticoagulants are used in atrial fibrillation. Idarucizumab has been approved for reversal of dabigatran in situations of life-threatening hemorrhage or emergency surgery. We report a single center experience of ten patients on dabigatran therapy who were given idarucizumab prior to heart transplantation. The mean plasma concentration of dabigatran prior to reversal was 139 ± 89 ng/ml. Hemoglobin, hematocrit and platelet levels were decreased after surgery. Surgical procedures were successfully performed with no increased risk, especially regarding bleeding complications. All patients were alive after 90 days. Dabigatran reversal with idarucizumab in contexts of emergency surgery/urgent procedures is an attractive and safe option to be taken into consideration for patients with end stage heart disease awaiting transplantation and indication of anticoagulant therapy.
Sections du résumé
BACKGROUND
BACKGROUND
Novel oral anticoagulants are used in atrial fibrillation. Idarucizumab has been approved for reversal of dabigatran in situations of life-threatening hemorrhage or emergency surgery.
OBJECTIVES
OBJECTIVE
We report a single center experience of ten patients on dabigatran therapy who were given idarucizumab prior to heart transplantation.
METHODS & RESULTS
RESULTS
The mean plasma concentration of dabigatran prior to reversal was 139 ± 89 ng/ml. Hemoglobin, hematocrit and platelet levels were decreased after surgery. Surgical procedures were successfully performed with no increased risk, especially regarding bleeding complications. All patients were alive after 90 days.
CONCLUSION
CONCLUSIONS
Dabigatran reversal with idarucizumab in contexts of emergency surgery/urgent procedures is an attractive and safe option to be taken into consideration for patients with end stage heart disease awaiting transplantation and indication of anticoagulant therapy.
Identifiants
pubmed: 33815827
doi: 10.2144/fsoa-2020-0186
pmc: PMC8015660
doi:
Types de publication
Journal Article
Langues
eng
Pagination
FSO689Informations de copyright
© 2021 Francois Roubille.
Déclaration de conflit d'intérêts
Financial & competing interests disclosure F Roubille and F Leclercq declare to have received honoraria for lectures from Boehringer-Ingelheim. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Medical writing support was provided by B Herve and was funded by Boehringer-Ingelheim.
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