Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease.
Crohn's disease
T cell trafficking
infiltration
inflammatory bowel disease
pediatric
ulcerative colitis
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
12
2020
accepted:
08
02
2021
entrez:
5
4
2021
pubmed:
6
4
2021
medline:
6
4
2021
Statut:
epublish
Résumé
T cell subsets are considered central orchestrators of inflammation and homeostasis in the intestine and are established targets for the treatment of inflammatory bowel disease. While approaches aimed at the neutralization of T cell effector cytokines have provided significant benefits for pediatric and adult patients, more recent strategies aimed at inhibiting the infiltration of pathogenic T cell subsets have also emerged. In this review, we describe current knowledge surrounding the function of T cell subsets in pediatric inflammatory bowel disease and outline approaches aimed at targeting T cell trafficking to the intestine which may represent a new treatment option for pediatric inflammatory bowel disease.
Identifiants
pubmed: 33816403
doi: 10.3389/fped.2021.640497
pmc: PMC8012547
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
640497Informations de copyright
Copyright © 2021 Giannoudaki, Gargan, Hussey, Long and Walsh.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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