Current opinion in neurological manifestations of SARS-CoV-2 infection.
ACE2
Blood–brain barrier
COVID-19
IL-6
Neuropilin-1
Thromboembolic complications
Journal
Current opinion in toxicology
ISSN: 2468-2934
Titre abrégé: Curr Opin Toxicol
Pays: Netherlands
ID NLM: 101697847
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
pubmed:
6
4
2021
medline:
6
4
2021
entrez:
5
4
2021
Statut:
ppublish
Résumé
Neurological symptoms occur in approximately one-third of hospitalized patients with coronavirus disease 2019 (COVID-19). Among these symptoms, hypoxic encephalopathy develops in one-fifth of severe cases, while ischemic strokes due to thrombotic complications are common in one-third of COVID-19 intensive care patients. Brain involvement of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is eventuated by several routes, including hematogenous spread, transsynaptic entry through infected neurons, olfactory nerve, ocular epithelium, vascular endothelium, and impaired blood-brain barrier. Besides the high angiotensin-converting enzyme-2 (ACE2) binding affinity, and FURIN preactivation, SARS-CoV-2 maintains efficient neuronal entry while evading immune surveillance by using basigin and neuropilin-1 receptors. However, the neurological manifestations and their pathogenic mechanisms are still debated in COVID-19 patients.
Identifiants
pubmed: 33817451
doi: 10.1016/j.cotox.2021.03.004
pii: S2468-2020(21)00008-5
pmc: PMC8006515
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
49-56Informations de copyright
© 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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