Assessment of pulmonary arterial circulation 3 months after hospitalization for SARS-CoV-2 pneumonia: Dual-energy CT (DECT) angiographic study in 55 patients.

COVID-19 CT angiography Dual-energy CT Lung perfusion Pulmonary embolism

Journal

EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727

Informations de publication

Date de publication:
Apr 2021
Historique:
entrez: 5 4 2021
pubmed: 6 4 2021
medline: 6 4 2021
Statut: ppublish

Résumé

During COVID-19, the main manifestations of the disease are not only pneumonia but also coagulation disorders. The purpose of this study was to evaluate pulmonary vascular abnormalities 3 months after hospitalization for SARS-CoV-2 pneumonia in patients with persistent respiratory symptoms. Among the 320 patients who participated in a systematic follow-up 3 months after hospitalization, 76 patients had residual symptoms justifying a specialized follow-up in the department of pulmonology. Among them, dual-energy CT angiography (DECTA) was obtained in 55 patients. The 55 patients had partial ( DECT depicted proximal arterial thrombosis in 5.4% of patients and perfusion abnormalities suggestive of widespread microangiopathy in 65.5% of patients. Lung microcirculation was abnormal in 4 patients with normal lung parenchyma.

Sections du résumé

BACKGROUND BACKGROUND
During COVID-19, the main manifestations of the disease are not only pneumonia but also coagulation disorders. The purpose of this study was to evaluate pulmonary vascular abnormalities 3 months after hospitalization for SARS-CoV-2 pneumonia in patients with persistent respiratory symptoms.
METHODS METHODS
Among the 320 patients who participated in a systematic follow-up 3 months after hospitalization, 76 patients had residual symptoms justifying a specialized follow-up in the department of pulmonology. Among them, dual-energy CT angiography (DECTA) was obtained in 55 patients.
FINDINGS RESULTS
The 55 patients had partial (
INTERPRETATION CONCLUSIONS
DECT depicted proximal arterial thrombosis in 5.4% of patients and perfusion abnormalities suggestive of widespread microangiopathy in 65.5% of patients. Lung microcirculation was abnormal in 4 patients with normal lung parenchyma.

Identifiants

DOI: 10.1016/j.eclinm.2021.100778 PMID: 33817609 PMC: PMC8008988
pubmed: 33817609
doi: 10.1016/j.eclinm.2021.100778
pii: S2589-5370(21)00058-4
pmc: PMC8008988
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100778

Informations de copyright

© 2021 Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Author MRJ received nonfinancial support for clinical research purposes from Siemens Healthineers. Author JR received personal fees as consultant for Siemens Healthineers and non-financial support for clinical research purposes. All other authors have nothing to declare.

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Auteurs

Martine Remy-Jardin (M)

Univ.Lille, CHU Lille, Department of Thoracic Imaging, ULR 2694 METRICS Evaluation des technologies de santé et des pratiques médicales, F-59000 LILLE, France.
Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.

Louise Duthoit (L)

Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.
Univ.Lille, CHU Lille, Department of Pulmonology, Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq, F-59000 LILLE, France.

Thierry Perez (T)

Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.
Department of Pulmonary Function Testing, Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq, F-59000 LILLE, France.

Paul Felloni (P)

Univ.Lille, CHU Lille, Department of Thoracic Imaging, ULR 2694 METRICS Evaluation des technologies de santé et des pratiques médicales, F-59000 LILLE, France.
Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.

Jean-Baptiste Faivre (JB)

Univ.Lille, CHU Lille, Department of Thoracic Imaging, ULR 2694 METRICS Evaluation des technologies de santé et des pratiques médicales, F-59000 LILLE, France.
Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.

Stéphanie Fry (S)

Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.
Univ.Lille, CHU Lille, Department of Pulmonology, Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq, F-59000 LILLE, France.

Nathalie Bautin (N)

Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.
Univ.Lille, CHU Lille, Department of Pulmonology, Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq, F-59000 LILLE, France.

Cécile Chenivesse (C)

Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.
Univ.Lille, CHU Lille, Department of Pulmonology, Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq, F-59000 LILLE, France.

Jacques Remy (J)

Univ.Lille, CHU Lille, Department of Thoracic Imaging, ULR 2694 METRICS Evaluation des technologies de santé et des pratiques médicales, F-59000 LILLE, France.
Hospital Calmette, University Hospital Center of Lille, Blvd Jules Leclercq F-59000 LILLE, France.

Alain Duhamel (A)

Univ.Lille, CHU Lille, Department of Biostatistics, ULR 2694 METRICS Evaluation des technologies de santé et des pratiques médicales, F-59000 LILLE, France.

Classifications MeSH