Astrocyte senescence and SASP in neurodegeneration: tau joins the loop.
Alzheimer’s disease
SASP
astrocyte senescence
neurodegeneration
p53 isoforms
tau
Journal
Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Titre abrégé: Cell Cycle
Pays: United States
ID NLM: 101137841
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
pubmed:
6
4
2021
medline:
27
1
2022
entrez:
5
4
2021
Statut:
ppublish
Résumé
Tau accumulation is a core component of Alzheimer's disease and other neurodegenerative tauopathies. While tau's impact on neurons is a major area of research, the effect of extracellular tau on astrocytes is largely unknown. This article summarizes our recent studies showing that astrocyte senescence plays a critical role in neurodegenerative diseases and integrates extracellular tau into the regulatory loop of senescent astrocyte-mediated neurotoxicity. Human astrocytes
Identifiants
pubmed: 33818291
doi: 10.1080/15384101.2021.1909260
pmc: PMC8098067
doi:
Substances chimiques
MAPT protein, human
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
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