Use of convalescent plasma for COVID-19 in India: A review & practical guidelines.

Antibody-dependent enhancement COVID-19 anti-SARS-CoV-2 antibodies convalescent plasma donor selection neutralizing antibodies passive immunization

Journal

The Indian journal of medical research
ISSN: 0971-5916
Titre abrégé: Indian J Med Res
Pays: India
ID NLM: 0374701

Informations de publication

Date de publication:
Historique:
entrez: 5 4 2021
pubmed: 6 4 2021
medline: 16 4 2021
Statut: ppublish

Résumé

Convalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and also in India. However, unequivocal proof of efficacy and effectiveness in COVID-19 is still not available. Various CP therapy parameters such as donor selection, antibody quantification, timing of use, and dosing need to be considered before its use. The current review attempts to summarize the available evidence and provide recommendations for setting up CP protocols in clinical and research settings.

Identifiants

pubmed: 33818467
pii: IndianJMedRes_2021_153_1_64_308620
doi: 10.4103/ijmr.IJMR_3092_20
pmc: PMC8184072
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

64-85

Déclaration de conflit d'intérêts

None

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Auteurs

Niranjan Shiwaji Khaire (NS)

Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Nishant Jindal (N)

Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Lakshmi Narayana Yaddanapudi (LN)

Department of Anaesthesia & Intensive Care, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Suchet Sachdev (S)

Department of Transfusion Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Rekha Hans (R)

Department of Transfusion Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Naresh Sachdeva (N)

Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Mini P Singh (MP)

Department of Virology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Anup Agarwal (A)

Clinical Trial & Health System Research Unit, Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.

Aparna Mukherjee (A)

Clinical Trial & Health System Research Unit, Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.

Gunjan Kumar (G)

Clinical Trial & Health System Research Unit, Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.

Ratti Ram Sharma (RR)

Department of Transfusion Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Vikas Suri (V)

Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Goverdhan Dutt Puri (GD)

Department of Anaesthesia & Intensive Care, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Pankaj Malhotra (P)

Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

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