Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).
African green monkey
Alzheimer's disease
cognitive decline
gait speed
vervet
Journal
American journal of primatology
ISSN: 1098-2345
Titre abrégé: Am J Primatol
Pays: United States
ID NLM: 8108949
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
05
03
2021
received:
09
12
2020
accepted:
21
03
2021
pubmed:
6
4
2021
medline:
25
11
2021
entrez:
5
4
2021
Statut:
ppublish
Résumé
Age-related neurodegeneration characteristic of late-onset Alzheimer's disease (LOAD) begins in middle age, well before symptoms. Translational models to identify modifiable risk factors are needed to understand etiology and identify therapeutic targets. Here, we outline the evidence supporting the vervet monkey (Chlorocebus aethiops sabaeus) as a model of aging-related AD-like neuropathology and associated phenotypes including cognitive function, physical function, glucose handling, intestinal physiology, and CSF, blood, and neuroimaging biomarkers. This review provides the most comprehensive multisystem description of aging in vervets to date. This review synthesizes a large body of evidence that suggests that aging vervets exhibit a coordinated suite of traits consistent with early AD and provide a powerful, naturally occurring model for LOAD. Notably, relationships are identified between AD-like neuropathology and modifiable risk factors. Gaps in knowledge and key limitations are provided to shape future studies to illuminate mechanisms underlying divergent neurocognitive aging trajectories and to develop interventions that increase resilience to aging-associated chronic disease, particularly, LOAD.
Identifiants
pubmed: 33818801
doi: 10.1002/ajp.23260
pmc: PMC8626867
mid: NIHMS1751612
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23260Subventions
Organisme : NIH HHS
ID : P40 OD010965
Pays : United States
Organisme : NIH HHS
ID : K08 AG065426
Pays : United States
Organisme : NIH HHS
ID : P30 AG21332
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG033534
Pays : United States
Organisme : NIH HHS
ID : RF1AG058829
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG073199
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072947
Pays : United States
Organisme : NIH HHS
ID : R01HL087103
Pays : United States
Organisme : NIH HHS
ID : P40-OD010965
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087103
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058829
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066509
Pays : United States
Organisme : NIA NIH HHS
ID : K08 AG065426
Pays : United States
Organisme : NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG068330
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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