Budding and Fission of Nanovesicles Induced by Membrane Adsorption of Small Solutes.
lipid bilayer
membrane neck
nanovesicle
neck fission
solute adsorption
vesicle budding
vesicle division
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
27 04 2021
27 04 2021
Historique:
pubmed:
6
4
2021
medline:
15
5
2021
entrez:
5
4
2021
Statut:
ppublish
Résumé
Membrane budding and fission are essential cellular processes that produce new membrane compartments during cell and organelle division, for intracellular vesicle trafficking as well as during endo- and exocytosis. Such morphological transformations have also been observed for giant lipid vesicles with a size of many micrometers. Here, we report budding and fission processes of lipid nanovesicles with a size below 50 nm. We use coarse-grained molecular dynamics simulations, by which we can visualize the morphological transformations of individual vesicles. The budding and fission processes are induced by low concentrations of small solutes that absorb onto the outer leaflets of the vesicle membranes. In addition to the solute concentration, we identify the solvent conditions as a second key parameter for these processes. For
Identifiants
pubmed: 33819031
doi: 10.1021/acsnano.1c00525
pmc: PMC8155335
doi:
Substances chimiques
Lipids
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7237-7248Références
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