Interactions of porphyrins with DNA: A review focusing recent advances in chemical modifications on porphyrins as artificial nucleases.
Anionic porphyrin
Cationic porphyrin
Heme proteins
Metalloporphyrins
Porphyrin conjugates
Porphyrin-DNA interactions
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
11
12
2020
revised:
18
03
2021
accepted:
18
03
2021
pubmed:
6
4
2021
medline:
18
1
2022
entrez:
5
4
2021
Statut:
ppublish
Résumé
The advance of porphyrins as artificial nucleases along the years have developed a class of compounds having potential therapeutic applications. Being an extrovert of chemistry, a variety of chemical modifications have been done on porphyrin macrocycle in order to improve the spectroscopic properties and to adapt as artificial receptors that can recognize molecules. The last twenty years has witnessed broad research in the arena of porphyrin- DNA interactions and their evolution from simple to more complex entities. In this review, we summarize the recent advances in the porphyrin-based structural modifications, with a specific emphasis on various effects of porphyrin on DNA cleavage potency. We particularly detailed the nuclease activity of cationic and anionic porphyrins, porphyrin dimers and conjugates as well as heme proteins till the third generation porphyrins as artificial nucleases.
Identifiants
pubmed: 33819802
pii: S0162-0134(21)00081-7
doi: 10.1016/j.jinorgbio.2021.111434
pii:
doi:
Substances chimiques
Anions
0
Cations
0
Hemeproteins
0
Metalloporphyrins
0
Metals
0
Porphyrins
0
DNA
9007-49-2
Endonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111434Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.