Intracellular Passage Triggers a Molecular Response in Brucella abortus That Increases Its Infectiousness.
Animals
Autophagosomes
Bacterial Adhesion
Bacterial Proteins
/ genetics
Brucella abortus
/ physiology
Brucellosis, Bovine
/ immunology
Cattle
Gene Expression Regulation, Bacterial
Host-Pathogen Interactions
/ immunology
Macrophages
/ microbiology
Type IV Secretion Systems
/ genetics
Virulence
/ genetics
adherent
brucellosis
host cells
host-pathogen interactions
infectiousness
intracellular life cycle
transcriptional regulator VjbR
two-component system
type IV secretion system
virulence circuit
Journal
Infection and immunity
ISSN: 1098-5522
Titre abrégé: Infect Immun
Pays: United States
ID NLM: 0246127
Informations de publication
Date de publication:
16 06 2021
16 06 2021
Historique:
pubmed:
7
4
2021
medline:
21
9
2021
entrez:
6
4
2021
Statut:
ppublish
Résumé
Brucella abortus is a facultatively extracellular-intracellular pathogen that encounters a diversity of environments within the host cell. We report that bacteria extracted from infected cells at late stages (48 h postinfection) of the intracellular life cycle significantly increase their ability to multiply in new target cells. This increase depends on early interaction with the cell surface, since the bacteria become more adherent and penetrate more efficiently than
Identifiants
pubmed: 33820813
pii: IAI.00004-21
doi: 10.1128/IAI.00004-21
pmc: PMC8373234
doi:
Substances chimiques
Bacterial Proteins
0
Type IV Secretion Systems
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0000421Références
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