Human Exposures to Neonicotinoids in Kumasi, Ghana.
Biomonitoring
Chronic reference dose
Imidacloprid equivalent
Neonicotinoid
Pesticide risk assessment
Pesticides
Journal
Environmental toxicology and chemistry
ISSN: 1552-8618
Titre abrégé: Environ Toxicol Chem
Pays: United States
ID NLM: 8308958
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
19
03
2021
received:
17
02
2021
accepted:
02
04
2021
pubmed:
7
4
2021
medline:
15
4
2022
entrez:
6
4
2021
Statut:
ppublish
Résumé
Neonicotinoid insecticides (NNIs) are now popular in many agricultural systems across Africa; however, the extent of human exposures to NNIs in African countries is scarcely reported. The present study evaluates neonicotinoid exposures in the consumer population of Kumasi, a cosmopolitan city in Ghana. A total of 75 human urine samples were collected from healthy volunteers (nonfarmers, aged 13-80 yr) and analyzed with a liquid chromatography electrospray ionization tandem mass spectrometry system. Seven NNIs and 3 NNI metabolites were detected in the following pattern (frequency, median concentration, maximum concentration): N-dm-acetamiprid (94.7%, 0.41 µg/L, 8.79 µg/L) > imidacloprid (70.7%, 0.15 µg/L, 211.62 µg/L) > N-(6-chloro-3-pyridylmethyl)-N-ethyl-N'-methylformamidine (62.2%, 0.43 µg/L, 53.85 µg/L) > 2-[N-(6-chloro-3-pyridylmethyl)-N-ethylamino]-2-(methylimino)acetic acid (56.8%, 0.10 µg/L, 3.53 µg/L) > clothianidin (40%, >limit of quantification [LOQ], 0.45 µg/L) > nitenpyram (18.7%, >LOQ, 0.14 µg/L) ≈ thiamethoxam (18.7%, >LOQ, 0.21 µg/L) > dinotefuran (12.0%, >LOQ, 1.01 µg/L) > acetamiprid (2.7%, >LOQ, 0.08 µg/L) ≈ thiacloprid (2.7%, >LOQ, 0.14 µg/L). Approximately 92% of the subjects were found to be exposed to multiple neonicotinoids simultaneously. The mean, median, and maximum imidacloprid equivalent of the relative potency factor of NNIs were found to be 1.6, 0.5, and 22.52, respectively. The median estimated daily intakes of acetamiprid, imidacloprid, and nitenpyram were 0.47, 1.27, and 0.02 µg/kg/d for females and 0.91, 0.66, and 0.08 µg/kg/d for males, respectively. The maximum daily intakes of all the NNIs were <1% of their chronic reference doses (cRfDs), except for imidacloprid and thiacloprid which recorded maximum daily intakes corresponding to 17.97 and 8.28% of cRfDs, respectively. To the best of our knowledge, the present study is the first biomonitoring report on neonicotinoid insecticides in Africa. Environ Toxicol Chem 2021;40:2306-2318. © 2021 SETAC.
Substances chimiques
Insecticides
0
Neonicotinoids
0
Nitro Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2306-2318Informations de copyright
© 2021 SETAC.
Références
Adam I , Amuquandoh FE . 2013. Dimensions of hotel location in the Kumasi metropolis, Ghana. Tour Manag Perspect 8:1-8.
Afari-Sefa V , Asare-Bediako E , Kenyon L , Micah A . 2015. Pesticide use practices and perceptions of vegetable farmers in the cocoa belts of the Ashanti and Western Regions of Ghana. Advances Crop Science Technol 3:174.
Antwi-Agyakwa KA , Osekre EA , Adu-Acheampong R , Ninsin KD . 2015. Insecticide use practices in cocoa production in four regions in Ghana. West African J Appl Ecol 22:39-48.
Baker SE , Serafim AB , Morales-Agudelo P , Vidal M , Calafat AM , Ospina M . 2018. Quantification of DEET and neonicotinoid pesticide biomarkers in human urine by online solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 422:669-678.
Casida JE . 2018. Neonicotinoids and other insect nicotinic receptor competitive modulators: Progress and prospects. Annu Rev Entomol 63:125-144.
Chen M , Tao L , McLean J , Lu C . 2014. Quantitative analysis of neonicotinoid insecticide residues in foods: Implication for dietary exposures. J Agric Food Chem 62:6082-6090.
Dankyi E , Carboo D , Gordon C , Fomsgaard SI . 2015. Application of the QuEChERS procedure and LC-MS/MS for the assessment of neonicotinoid insecticide residues in cocoa beans and shells. J Food Compost Anal 44:149-157.
Dankyi E , Gordon C , Carboo D , Fomsgaard SI . 2014. Quantification of neonicotinoid insecticide residues in soils from cocoa plantations using a QuEChERS extraction procedure and LC-MS/MS. J Food Compost Anal 44:149-157.
Deshmukh M , Shripanavar C . 2011. Synthesis of N'-carbamoyl-N-[(6-chloropyridin-3-yl)methyl]ethanimidamide. J Chem Pharm Res 3:636-637.
Feher J . 2017. Tubular reabsorption and secretion, Quantitative Human Physiology: An Introduction, 2nd ed. Elsevier, London, UK, pp 719-729.
Fianko RJ , Donkor A , Lowor TS , Yeboah OP . 2011. Agrochemicals and the Ghanaian Environment, a Review. J Environ Prot (Irvine, Calif) 2:221-230.
Food Safety Committee. 2016. Pesticide evaluation report: Nitenpyram. Heisei Central Environmental Council, Tokyo, Japan (in Japanese). [cited 2021 January 20]. Available from: https://www.env.go.jp/council/10dojo/y104-63/ref02.pdf
Harada KH , Tanaka K , Sakamoto H , Imanaka M , Niisoe T , Hitomi T , Kobayashi H , Okuda H , Inoue S , Kusakawa K , Oshima M , Watanabe K , Yasojima M , Takasuga T , Koizumi A . 2016. Biological monitoring of human exposure to neonicotinoids using urine samples, and neonicotinoid excretion kinetics. PLoS One 11:e0146335.
Hirano T , Yanaia S , Takada T , Yoneda N , Omotehara T , Kubota N , Minami K , Yamamoto A , Mantani Y , Yokoyama T , Kitagawa H , Hoshi N . 2018. NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment. Toxicol Lett 282:57-63.
Honda M , Robinson R , Kannan K . 2019. A simple method for the analysis of neonicotinoids and their metabolites in human urine. Environ Chem 16:171-178.
Hornung RW , Reed LD . 1990. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg 5:46-51.
Ikenaka Y , Fujioka K , Kawakami T , Ichise I , Bortey-Sam N , Nakayama MMS , Mizukawa H , Taira K , Takahashi K , Kato K , Arizono K , Ishizuka K . 2018. Contamination by neonicotinoid insecticides and their metabolites in Sri Lankan black tea leaves and Japanese green tea leaves. Toxicol Rep 5:744-749.
Ikenaka Y , Miyabara Y , Ichise T , Nakayama S , Nimako C , Ishizuka M , Tohyama C . 2019. Exposures of children to neonicotinoids in pine wilt disease control areas. Environ Toxicol Chem 38:71-79.
Index Mundi. 2018. Ghana demographics profile. [cited 2021 February 17]. Available from: https://www.indexmundi.com/ghana/demographics_profile.html
Joint Food and Agriculture Organization/World Health Organization Meeting on Pesticide Residues. 2005. Acetamiprid. [cited 2021 January 31]. Available from: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwjuvaWujMbwAhWQGqYKHQgEBfEQFjABegQIBBAD&url=http%3A%2F%2Fwww.fao.org%2Ffileadmin%2Ftemplates%2Fagphome%2Fdocuments%2FPests_Pesticides%2FJMPR%2FReport11%2FAcetamiprid.pdf&usg=AOvVaw1TJRYlhekk16y6tHFVkf07
Joint Food and Agriculture Organization/World Health Organization Meeting on Pesticide Residues. 2010. Thiomethoxam (245) (T, R). In Pesticide Residues in Food 2010. FAO Plant Production and Protection Paper 200. Rome, Italy, pp 313-364. [cited 2018 June 13]. Available from: http://www.fao.org/fileadmin/templates/agphome/documents/Pests_Pesticides/JMPR/Evaluation10/2010_Evaluation.pdf
Kabata R , Nanayakkara S , Senevirathna S , Harada KH , Chandrajith R , Hitomi T , Abeysekera T , Takasuga T , Koizumi A . 2016. Neonicotinoid concentrations in urine from chronic kidney disease patients in North Central Region of Sri Lanka. J Occup Health 58:128-133.
Karami-Mohajeri S , Abdollahi M . 2010. Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates: A systematic review. Hum Exp Toxicol 30:1119-1140.
Kwakye OM , Mengistie B , Ofosu-Anim J , Nuer KTA , Brink VJP . 2018. Pesticide registration, distribution and use practices in Ghana. Environ Dev Sustain 21:2667-2691.
Li AJ , Kannan K . 2018. Urinary concentrations and profiles of organophosphate and pyrethroid pesticide metabolites and phenoxyacid herbicides in populations in eight countries. Environ Int 121:1148-1154.
Li AJ , Kannan K . 2020. Profiles of urinary neonicotinoids and dialkylphosphates in populations in nine countries. Environ Int 145:106120.
Li AJ , Martinez-Moral MP , Kannan K . 2020. Variability in urinary neonicotinoid concentrations in single-spot and first-morning void and its association with oxidative stress markers. Environ Int 135:105415.
Li P , Ann J , Akk G . 2011. Activation and modulation of human a4b2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid. J Neurosci Res 89:1295-1301.
Lu C , Chang C , Palmer C , Zhao M , Zhang Q . 2018. Neonicotinoid residues in fruits and vegetables: An integrated dietary exposure assessment. Environ Sci Technol 52:3175-3184.
Metcalf LR . 1989. Insect resistance to insecticide. Pestic Sci 26:333-358.
Ministry of Food and Agriculture. 2018. Kumasi Metropolitan. [cited 2018 June 20]. Available from: http://mofa.gov.gh/site/?page_id=859
Mitchell DAE , Mulhauser B , Mulot M , Mutabazi A , Glauser G , Aebi1 A . 2017. A worldwide survey of neonicotinoids in honey. Science 358:109-111.
Natural Resources Defense Council. 2016. Clothianidin (CAS# 210880-92-5) GreenScreen® for safer chemicals (GreenScreen®) assessment. Bethesda, MD, USA. [cited 2018 March 28]. Available from: https://ntp.niehs.nih.gov/ntp/ohat/publiccomms/2016/attachment-3.pdf
Ndiath MO . 2019. Insecticides and insecticide resistance. In Ariey F , Gay F , & Ménard R , eds, Malaria Control and Elimination. Vol 2013-Methods in Molecular Biology Humana, New York, NY, USA.
Network of African Science Academies. 2019. Neonicotinoid insecticides: Use and effects in African agriculture. A review and recommendations to policymakers. Nairobi, Kenya. [cited 2021 January 31]. Available from: https://www.interacademies.org/publication/neonicotinoid-insecticides-use-and-effects-african-agriculture-review-and
Northern Presbyterian Agricultural Services and Partners. 2012. Ghana's pesticide crisis: The need for further government action. NPAS, Tamale, Ghana (pp 1-50). [cited 2021 May]. Available from: https://reliefweb.int/report/ghana/ghana%E2%80%99s-pesticide-crisis
Ospina M , Wong LY , Baker SE , Serafim AB , Morales-Agudelo P , Calafat AM . 2019. Exposure to neonicotinoid insecticides in the US general population: Data from the 2015-2016 national health and nutrition examination survey. Environ Res 176:108555.
Sano K , Isobe T , Yang J , Win-Shwe T-T , Yoshikane M , Nakayama SF , Kawashima T , Suzuki G , Hashimoto S , Nohara K , Tohyama C , Maekawa F . 2016. In utero and lactational exposure to acetamiprid induces abnormalities in socio-sexual and anxiety-related behaviors of male mice. Front Neurosci 10:1-12.
Simon-Delso N , Amaral-Rogers V , Belzunces LP , Bonmatin JM , Chagnon M , Down C , Furlan L , Gibbons DW , Giorio C , Girolami V , Goulson D , Kreutzweiser DP , Krupke CH , Liess M , Long E , McField M , Mineau P , Mitchell EAD , Morrissey CA , Noome DA , Pisa L , Settele J , Stark JD , Tapparo A , Van Dyck H , Van Praagh J , Van der Sluijs JP , Whitehorn PR , Wiemers M . 2015. Systemic insecticides (neonicotinoids and fipronil): Trends, uses, mode of action and metabolites. Environ Sci Pollut Res 22:5-34.
Song S , Zhang T , Huang Y , Zhang B , Guo Y , He Y , Huang X , Bai X , Kannan K . 2020. Urinary metabolites of neonicotinoid insecticides: Levels and recommendations for future biomonitoring studies in China. Environ Sci Technol 54:8210-8220.
Sun Q , Xiao X , Kim Y , Kim D , Yoon SK , Clark MJ , Park Y . 2016. Imidacloprid promotes high fat diet-induced adiposity and insulin resistance in male C57BL/6 J mice. J Agric Food Chem 64:9293-9306.
Taira K . 2014. Human neonicotinoids exposure in Japan. Japanese Journal of Clinical Ecology 1:14-23.
Taira K , Fujioka K , Aoyama Y . 2013. Qualitative profiling and quantification of neonicotinoid metabolites in human urine by liquid chromatography coupled with mass spectrometry. PLoS One 8:e80332.
Ueyama J , Arisa A , Ueda Y , Oya N , Sugiuraa Y , Ito Y , Ebara T , Kamijima M . 2020. Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 37:304-315.
Ueyama J , Harada HK , Koizumi A , Sugiura Y , Kondo T , Saito I , Kamijima M . 2015. Temporal level of urinary neonicotinoid and dialkylphosphate concentrations in Japanese women between 1994 and 2011. Environ Sci Technol 49:14522-14528.
Ueyama J , Nomura H , Kondo T , Saito I , Ito Y , Osaka A , Kamijima M . 2014. Biological monitoring method for urinary neonicotinoid insecticides using LC-MS/MS and its application to Japanese adults. J Occup Health 56:461-468.
Wang A , Mahai G , Wan Y , Yang Z , He Z , Xu S , Xia W . 2020. Assessment of imidacloprid related exposure using imidacloprid-olefin and desnitro-imidacloprid: Neonicotinoid insecticides in human urine in Wuhan, China. Environ Int 141:105785.
Wang X , Anadón A , Qinghua W , Qiao F , Ares I , Martínez-Larrañaga M-R , Yuan Z , Martínez M-A . 2018. Mechanism of neonicotinoid toxicity: Impact on oxidative stress and metabolism. Annu Rev Pharmacol Toxicol 58:471-507.
Xu M , Zhang Z , Li Z , Kan S , Liu Z , Wang D , Liu Q , Zhang H . 2021. Profiles of neonicotinoid insecticides and characteristic metabolites in paired urine and blood samples: Partitioning between urine and blood and implications for human exposure. Sci Total Environ 773:145582.
Zhang Q , Li Z , Chang CH , Lou LJ , Zhao RM , Lu C . 2018. Potential human exposures to neonicotinoid insecticides: A review. Environ Pollut 236:71-81.
Zhang T , Song S , Bai X , He Y , Zhang B , Gui M , Kannan K , Lu S , Huang Y , Sun H . 2019. A nationwide survey of urinary concentrations of neonicotinoid insecticides in China. Environ Int 132:105114.