Use of Intramolecular 1,5-Sulfur-Oxygen and 1,5-Sulfur-Halogen Interactions in the Design of
Animals
Drug Design
Half-Life
Halogens
/ chemistry
Humans
Male
Mice
Molecular Conformation
Motor Neurons
/ metabolism
Muscular Atrophy, Spinal
/ genetics
Oxygen
/ chemistry
Pyridazines
/ chemistry
RNA Splicing
/ drug effects
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Sulfur
/ chemistry
Survival of Motor Neuron 1 Protein
/ genetics
Survival of Motor Neuron 2 Protein
/ genetics
Thiadiazoles
/ chemistry
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
22 04 2021
22 04 2021
Historique:
pubmed:
7
4
2021
medline:
16
6
2021
entrez:
6
4
2021
Statut:
ppublish
Résumé
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of the survival motor neuron 1 (
Identifiants
pubmed: 33822618
doi: 10.1021/acs.jmedchem.0c02173
doi:
Substances chimiques
Halogens
0
Pyridazines
0
SMN1 protein, human
0
SMN2 protein, human
0
Survival of Motor Neuron 1 Protein
0
Survival of Motor Neuron 2 Protein
0
Thiadiazoles
0
1,3,4-thiadiazole
14IAC3GH7G
pyridazine
449GLA0653
Sulfur
70FD1KFU70
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM