JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer.
Alternative Splicing
Antineoplastic Agents
/ therapeutic use
Cell Line, Tumor
Cohort Studies
Enzyme Inhibitors
/ therapeutic use
Gene Expression Regulation, Neoplastic
Humans
Jumonji Domain-Containing Histone Demethylases
/ antagonists & inhibitors
Male
Molecular Targeted Therapy
Oxygenases
/ genetics
Prognosis
Prostatic Neoplasms, Castration-Resistant
/ diagnosis
Protein Isoforms
/ genetics
Receptors, Androgen
/ chemistry
Retrospective Studies
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
28
05
2020
revised:
07
09
2020
accepted:
02
12
2020
entrez:
6
4
2021
pubmed:
7
4
2021
medline:
13
5
2021
Statut:
ppublish
Résumé
Endocrine resistance (EnR) in advanced prostate cancer is fatal. EnR can be mediated by androgen receptor (AR) splice variants, with AR splice variant 7 (AR-V7) arguably the most clinically important variant. In this study, we determined proteins key to generating AR-V7, validated our findings using clinical samples, and studied splicing regulatory mechanisms in prostate cancer models. Triangulation studies identified JMJD6 as a key regulator of AR-V7, as evidenced by its upregulation with
Identifiants
pubmed: 33822745
pii: 81/4/1087
doi: 10.1158/0008-5472.CAN-20-1807
pmc: PMC8025710
mid: NIHMS1653942
doi:
Substances chimiques
AR protein, human
0
Antineoplastic Agents
0
Enzyme Inhibitors
0
Protein Isoforms
0
Receptors, Androgen
0
Oxygenases
EC 1.13.-
JMJD6 protein, human
EC 1.14.11.-
Jumonji Domain-Containing Histone Demethylases
EC 1.14.11.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1087-1100Subventions
Organisme : European Research Council
ID : 683136
Pays : International
Organisme : Prostate Cancer UK
ID : CEO13_2-002
Pays : United Kingdom
Organisme : BLRD VA
ID : I01 BX003324
Pays : United States
Organisme : Wellcome Trust
ID : 106244/Z/14/Z
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U54 CA126540
Pays : United States
Organisme : Cancer Research UK
ID : C8717/A18245
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M018318/1
Pays : United Kingdom
Informations de copyright
©2021 American Association for Cancer Research.
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