Lumipulse G SARS-CoV-2 Ag assay evaluation using clinical samples from different testing groups.
SARS-CoV-2
antigen detection
lumipulse assay
nasopharyngeal swab
testing group
Journal
Clinical chemistry and laboratory medicine
ISSN: 1437-4331
Titre abrégé: Clin Chem Lab Med
Pays: Germany
ID NLM: 9806306
Informations de publication
Date de publication:
27 07 2021
27 07 2021
Historique:
received:
08
02
2021
accepted:
29
03
2021
pubmed:
7
4
2021
medline:
8
7
2021
entrez:
6
4
2021
Statut:
epublish
Résumé
Compared to RT-PCR, lower performance of antigen detection assays, including the Lumipulse G SARS-CoV-2 Ag assay, may depend on specific testing scenarios. We tested 594 nasopharyngeal swab samples from individuals with COVID-19 (RT-PCR cycle threshold [Ct] values ≤ 40) or non-COVID-19 (Ct values >40) diagnoses. RT-PCR positive samples were assigned to diagnostic, screening, or monitoring groups of testing. With a limit of detection of 1.2 × 10 Lumipulse assay was highly sensitive in samples with low RT-PCR Ct values, implying repeated testing to reduce consequences of false-negative results.
Identifiants
pubmed: 33823089
pii: cclm-2021-0182
doi: 10.1515/cclm-2021-0182
doi:
Substances chimiques
RNA, Viral
0
Reagent Kits, Diagnostic
0
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1468-1476Informations de copyright
© 2021 Giulia Menchinelli et al., published by De Gruyter, Berlin/Boston.
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