A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Biomarkers Cell Cycle / genetics Computational Biology Energy Metabolism Gene Ontology Host Microbial Interactions Humans Mechanistic Target of Rapamycin Complex 1 / metabolism Mechanistic Target of Rapamycin Complex 2 / metabolism Nitrogen / metabolism Phosphoproteins / genetics Proteome Schizosaccharomyces / genetics Schizosaccharomyces pombe Proteins / genetics Signal Transduction Stress, Physiological TOR Serine-Threonine Kinases / genetics
Byr1 MAPKK TORC1 TORC2 fission yeast Schizosaccharomyces pombe nitrogen stress phosphoproteome

Journal

Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419

Informations de publication

Date de publication:
04 2021
Historique:
entrez: 7 4 2021
pubmed: 8 4 2021
medline: 3 2 2022
Statut: ppublish

Résumé

Fluctuations in TOR, AMPK and MAP-kinase signalling maintain cellular homeostasis and coordinate growth and division with environmental context. We have applied quantitative, SILAC mass spectrometry to map TOR and nutrient-controlled signalling in the fission yeast

Identifiants

DOI: 10.1098/rsob.200405 PMID: 33823663 PMC: PMC8025308
pubmed: 33823663
doi: 10.1098/rsob.200405
pmc: PMC8025308
doi:

Substances chimiques

Biomarkers 0
Phosphoproteins 0
Proteome 0
Schizosaccharomyces pombe Proteins 0
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
Mechanistic Target of Rapamycin Complex 2 EC 2.7.11.1
TOR Serine-Threonine Kinases EC 2.7.11.1
Nitrogen N762921K75

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

200405

Subventions

Organisme : Cancer Research UK
ID : C10888/A11178
Pays : United Kingdom

Références

Anal Chem. 2004 Jul 1;76(13):3590-8
pubmed: 15228329
Exp Cell Res. 1977 Jul;107(2):377-86
pubmed: 872891
Eukaryot Cell. 2012 Feb;11(2):159-67
pubmed: 22140232
J Cell Sci. 1992 Nov;103 ( Pt 3):665-75
pubmed: 1478963
Nature. 2015 Jan 15;517(7534):302-10
pubmed: 25592535
Open Biol. 2018 May;8(5):
pubmed: 29720420
Curr Biol. 2015 Feb 16;25(4):445-54
pubmed: 25639242
Mol Cell. 2003 Dec;12(6):1607-13
pubmed: 14690612
Cell Rep. 2018 Jul 10;24(2):503-514
pubmed: 29996109
Cold Spring Harb Protoc. 2016 Jun 01;2016(6):
pubmed: 27250942
Cell. 2017 Oct 19;171(3):642-654.e12
pubmed: 29053970
Nat Methods. 2007 Mar;4(3):207-14
pubmed: 17327847
J Cell Sci. 2010 Mar 1;123(Pt 5):777-86
pubmed: 20144990
Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
J Cell Sci. 2014 Mar 15;127(Pt 6):1346-56
pubmed: 24424027
Nature. 2011 Apr 21;472(7343):366-9
pubmed: 21441910
Cell Metab. 2014 Dec 2;20(6):939-52
pubmed: 25448702
Mol Cell Biol. 2007 Apr;27(8):3154-64
pubmed: 17261596
Diabetes. 2014 Dec;63(12):4115-29
pubmed: 25008179
Nat Protoc. 2018 Sep;13(9):1897-1916
pubmed: 30190555
Science. 2011 Jun 10;332(6035):1322-6
pubmed: 21659605
Elife. 2018 Mar 29;7:
pubmed: 29595474
Sci Signal. 2011 Jun 28;4(179):rs6
pubmed: 21712547
Nature. 1989 Mar 2;338(6210):83-7
pubmed: 2645527
Cell. 2016 Dec 15;167(7):1750-1761.e16
pubmed: 27984725
Genetics. 2019 Aug;212(4):1205-1225
pubmed: 31213504
Elife. 2014 Mar 11;3:e01695
pubmed: 24618897
J Cell Sci. 1977 Apr;24:51-67
pubmed: 893551
Genome Res. 2010 Jun;20(6):837-46
pubmed: 20237107
Biochemistry. 1995 Feb 28;34(8):2610-20
pubmed: 7873542
Elife. 2018 Jun 11;7:
pubmed: 29889021
Open Biol. 2014 Jul;4(7):
pubmed: 24990387
J Cell Sci. 2006 Nov 1;119(Pt 21):4475-85
pubmed: 17046992
Nature. 2005 May 26;435(7041):507-12
pubmed: 15917811
Trends Biochem Sci. 2016 Jun;41(6):532-545
pubmed: 27161823
Cold Spring Harb Protoc. 2016 Mar 01;2016(3):pdb.top079764
pubmed: 26933253
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Science. 2011 Jun 10;332(6035):1317-22
pubmed: 21659604
Sci Rep. 2019 Feb 6;9(1):1461
pubmed: 30728400
Mol Biol Cell. 2010 Oct 1;21(19):3475-86
pubmed: 20702584
Semin Cell Biol. 1995 Apr;6(2):95-104
pubmed: 7548848
Mol Cell Biol. 2000 Feb;20(4):1254-62
pubmed: 10648611
J Proteome Res. 2011 Apr 1;10(4):1794-805
pubmed: 21254760
Nat Commun. 2020 Jul 15;11(1):3535
pubmed: 32669568
Mol Cell Proteomics. 2005 Dec;4(12):2010-21
pubmed: 16249172
Nat Protoc. 2007;2(8):1896-906
pubmed: 17703201
Nat Commun. 2018 Aug 16;9(1):3275
pubmed: 30115907
Nat Cell Biol. 2007 Nov;9(11):1263-72
pubmed: 17952063
J Cell Sci. 2016 Jul 1;129(13):2613-24
pubmed: 27206859
Cell Rep. 2019 Sep 24;28(13):3486-3496.e6
pubmed: 31553916
Epigenetics Chromatin. 2019 Jul 17;12(1):45
pubmed: 31315658
Curr Biol. 2016 Feb 8;26(3):319-30
pubmed: 26776736
Autophagy. 2014 Feb;10(2):339-55
pubmed: 24300666
Mol Cell Proteomics. 2014 Aug;13(8):1925-36
pubmed: 24763107
Mol Cell Biol. 1995 Jul;15(7):3697-707
pubmed: 7791776
Science. 2013 Mar 15;339(6125):1320-3
pubmed: 23429704
Mol Cell Proteomics. 2012 May;11(5):160-70
pubmed: 22496350
Genes Cells. 2007 Dec;12(12):1357-70
pubmed: 18076573
EMBO Rep. 2017 Dec;18(12):2197-2218
pubmed: 29079657
Nat Methods. 2017 May;14(5):504-512
pubmed: 28319114
Mol Cell Biol. 2012 Jan;32(1):2-11
pubmed: 22025673
PLoS One. 2017 Mar 8;12(3):e0172740
pubmed: 28273166
Methods Mol Biol. 2009;492:131-42
pubmed: 19241030
J Biol Chem. 2009 Mar 20;284(12):8023-32
pubmed: 19150980
PLoS One. 2014 May 21;9(5):e97683
pubmed: 24848109

Auteurs

Lenka Halova (L)

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, UK.

David Cobley (D)

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

Mirita Franz-Wachtel (M)

Proteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.

Tingting Wang (T)

Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia 5042, Australia.

Kaitlin R Morrison (KR)

Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia 5042, Australia.

Karsten Krug (K)

Proteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.

Nicolas Nalpas (N)

Proteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.

Boris Maček (B)

Proteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.

Iain M Hagan (IM)

Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, UK.

Sean J Humphrey (SJ)

Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, Australia.

Janni Petersen (J)

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia 5042, Australia.
Nutrition and Metabolism, South Australia Health and Medical Research Institute, North Terrace, Adelaide, South Australia 5000, Australia.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Vocabulaire contrôlé › Ontologies biologiques › Gene Ontology › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-2 cible mécanistique de la rapamycine › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Azote › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Schizosaccharomyces › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Schizosaccharomyces pombe › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › A TOR (target of rapamycin) and nutritional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › A TOR (target of rapamycin) and nutritional...