Collagenous gastritis: Epidemiology and clinical associations.
Autoimmune gastritis
Celiac disease
Collagenous gastritis
Duodenal intraepithelial lymphocytosis
Environmental risk factors
Epidemiology
Helicobacter pylori
Microscopic colitis
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
19
02
2021
revised:
04
03
2021
accepted:
10
03
2021
pubmed:
8
4
2021
medline:
4
2
2022
entrez:
7
4
2021
Statut:
ppublish
Résumé
the rare occurrence of collagenous gastritis (CG) makes its epidemiology difficult to investigate. We designed a study to determine the demographic and clinical characteristics as well as the associations of CG with other upper gastrointestinal diseases in a large national clinicopathological database. from the IDEA database we extracted all patients with histopathologically documented CG and, in a case-control study, we compared 168 subjects with and 1,286,165 subjects without CG using odds ratios (OR) with their 95% confidence intervals (CI). the prevalence of CG was 13 per 100,000 EGDs. CG was significantly more common among female than male patients (OR: 1.69, 95% CI: 1.20-2.39) and was characterized by a bi-modal age distribution (first peak in patients aged 10-19, second peak primarily in females aged >60 years). CG patients presented with diarrhea (18%), anemia (12%), weight loss (11%), and vomiting (10%). CG was significantly associated with other lymphocytic disorders of the upper gastrointestinal tract, including celiac sprue (2.12, 1.55-2.88), duodenal intraepithelial lymphocytosis (3.71, 2.30-5.98), and lymphocytic gastritis (23.2, 10.9-49.5). CG persisted in 69% of patients who underwent multiple consecutive endoscopies. the epidemiologic features of collagenous gastritis reflect on different etiologies contributing to its occurrence in children and adults.
Sections du résumé
BACKGROUND
BACKGROUND
the rare occurrence of collagenous gastritis (CG) makes its epidemiology difficult to investigate. We designed a study to determine the demographic and clinical characteristics as well as the associations of CG with other upper gastrointestinal diseases in a large national clinicopathological database.
METHODS
METHODS
from the IDEA database we extracted all patients with histopathologically documented CG and, in a case-control study, we compared 168 subjects with and 1,286,165 subjects without CG using odds ratios (OR) with their 95% confidence intervals (CI).
RESULTS
RESULTS
the prevalence of CG was 13 per 100,000 EGDs. CG was significantly more common among female than male patients (OR: 1.69, 95% CI: 1.20-2.39) and was characterized by a bi-modal age distribution (first peak in patients aged 10-19, second peak primarily in females aged >60 years). CG patients presented with diarrhea (18%), anemia (12%), weight loss (11%), and vomiting (10%). CG was significantly associated with other lymphocytic disorders of the upper gastrointestinal tract, including celiac sprue (2.12, 1.55-2.88), duodenal intraepithelial lymphocytosis (3.71, 2.30-5.98), and lymphocytic gastritis (23.2, 10.9-49.5). CG persisted in 69% of patients who underwent multiple consecutive endoscopies.
CONCLUSIONS
CONCLUSIONS
the epidemiologic features of collagenous gastritis reflect on different etiologies contributing to its occurrence in children and adults.
Identifiants
pubmed: 33824091
pii: S1590-8658(21)00124-9
doi: 10.1016/j.dld.2021.03.010
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1136-1140Informations de copyright
Copyright © 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest RM Genta, KO Turner, and CJ Morgan are employed by Inform Diagnostics, Irving, TX. A Sonnenberg has no conflict of interest to declare. No funding was obtained for this study. Author Contributions: Study conception and design: A Sonnenberg, RM Genta; data analysis: A Sonnenberg, RM Genta, KO Turner; review of biopsy specimens and photographs: CJ Morgan; writing of manuscript: RM Genta, A Sonnenberg.