Cognitive Dysfunction and Gait Abnormalities in CKD.
chronic kidney disease
cognitive dysfunction
gait
geriatric nephrology
Journal
Clinical journal of the American Society of Nephrology : CJASN
ISSN: 1555-905X
Titre abrégé: Clin J Am Soc Nephrol
Pays: United States
ID NLM: 101271570
Informations de publication
Date de publication:
08 05 2021
08 05 2021
Historique:
received:
12
10
2020
accepted:
11
02
2021
pubmed:
8
4
2021
medline:
21
1
2022
entrez:
7
4
2021
Statut:
ppublish
Résumé
Cognitive impairment is a major cause of morbidity in CKD. We hypothesized that gait abnormalities share a common pathogenesis with cognitive dysfunction in CKD, and therefore would be associated with impaired cognitive function in older adults with CKD, and focused on a recently defined gait phenotype linked with CKD. Gait assessments and neuropsychological testing were performed in 312 nondisabled, community-dwelling older adults (aged ≥65 years). A subset ( Lower eGFR was associated with lower RBANS score only among participants with the gait phenotype ( The gait phenotype was associated with poorer function in a number of cognitive domains among older adults with CKD, and was associated with incident mild cognitive impairment independent of eGFR. CKD and the gait phenotype were associated with a shared pattern of gray matter atrophy.
Sections du résumé
BACKGROUND AND OBJECTIVES
Cognitive impairment is a major cause of morbidity in CKD. We hypothesized that gait abnormalities share a common pathogenesis with cognitive dysfunction in CKD, and therefore would be associated with impaired cognitive function in older adults with CKD, and focused on a recently defined gait phenotype linked with CKD.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
Gait assessments and neuropsychological testing were performed in 312 nondisabled, community-dwelling older adults (aged ≥65 years). A subset (
RESULTS
Lower eGFR was associated with lower RBANS score only among participants with the gait phenotype (
CONCLUSIONS
The gait phenotype was associated with poorer function in a number of cognitive domains among older adults with CKD, and was associated with incident mild cognitive impairment independent of eGFR. CKD and the gait phenotype were associated with a shared pattern of gray matter atrophy.
Identifiants
pubmed: 33824156
pii: 01277230-202105000-00008
doi: 10.2215/CJN.16091020
pmc: PMC8259490
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
694-704Subventions
Organisme : NIA NIH HHS
ID : R01 AG044007
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK099438
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036921
Pays : United States
Informations de copyright
Copyright © 2021 by the American Society of Nephrology.
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