Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation.

Carbon Radioisotopes / chemistry Catalysis Coordination Complexes / chemistry Cycloaddition Reaction Isotope Labeling Molecular Conformation Nitriles / chemistry Pharmaceutical Preparations / chemistry Transition Elements / chemistry Zinc / chemistry

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
21 04 2021
Historique:
pubmed: 8 4 2021
medline: 28 9 2021
entrez: 7 4 2021
Statut: ppublish

Résumé

The incorporation of carbon-14 allows tracking of organic molecules and provides vital knowledge on their fate. This information is critical in pharmaceutical development, crop science, and human food safety evaluation. Herein, a transition-metal-catalyzed procedure enabling carbon isotope exchange on aromatic nitriles is described. By utilizing the radiolabeled precursor Zn([

Identifiants

DOI: 10.1021/jacs.1c01923 PMID: 33825486
pubmed: 33825486
doi: 10.1021/jacs.1c01923
doi:

Substances chimiques

Carbon Radioisotopes 0
Coordination Complexes 0
Nitriles 0
Pharmaceutical Preparations 0
Transition Elements 0
Carbon-14 7V68J5677O
Zinc J41CSQ7QDS

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5659-5665

Auteurs

Minghao Feng (M)

Université Paris Saclay, CEA, DMTS, Service de Chimie Bio-organique et Marquage, 91191 Gif-sur-Yvette, France.
ORCID: 0000-0002-8220-9187

Joao De Oliveira (J)

Université Paris Saclay, CEA, DMTS, Service de Chimie Bio-organique et Marquage, 91191 Gif-sur-Yvette, France.
Isotope Chemistry, Integrated Drug Discovery Sanofi R&D, 94403 Vitry-sur-Seine, France.

Antoine Sallustrau (A)

Université Paris Saclay, CEA, DMTS, Service de Chimie Bio-organique et Marquage, 91191 Gif-sur-Yvette, France.

Gianluca Destro (G)

Université Paris Saclay, CEA, DMTS, Service de Chimie Bio-organique et Marquage, 91191 Gif-sur-Yvette, France.
Université Paris Saclay, CEA, CNRS, NIMBE, 91191 Gif-sur-Yvette, France.

Pierre Thuéry (P)

Université Paris Saclay, CEA, CNRS, NIMBE, 91191 Gif-sur-Yvette, France.
ORCID: 0000-0003-1683-570X

Sebastien Roy (S)

Isotope Chemistry, Integrated Drug Discovery Sanofi R&D, 94403 Vitry-sur-Seine, France.

Thibault Cantat (T)

Université Paris Saclay, CEA, CNRS, NIMBE, 91191 Gif-sur-Yvette, France.
ORCID: 0000-0001-5265-8179

Charles S Elmore (CS)

Isotope Chemistry, Pharmaceutical Science, R&D, AstraZeneca, 43183 Gothenburg, Sweden.

Jorg Blankenstein (J)

Isotope Chemistry, Integrated Drug Discovery Sanofi R&D, 94403 Vitry-sur-Seine, France.

Frédéric Taran (F)

Université Paris Saclay, CEA, DMTS, Service de Chimie Bio-organique et Marquage, 91191 Gif-sur-Yvette, France.
ORCID: 0000-0001-5461-329X

Davide Audisio (D)

Université Paris Saclay, CEA, DMTS, Service de Chimie Bio-organique et Marquage, 91191 Gif-sur-Yvette, France.
ORCID: 0000-0002-6234-3610

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Réaction de cycloaddition › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Techniques d'investigation › Marquage isotopique › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Composés chimiques organiques › Nitriles › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Préparations pharmaceutiques › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Éléments de transition › Direct Carbon Isotope Exchange of...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zinc › Direct Carbon Isotope Exchange of...