Cystathionine gamma-lyase/H
H2S
MEF2c
S-sulfhydration
aging
cystathionine gamma-lyase
myogenesis
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
10
02
2021
received:
07
12
2020
accepted:
22
02
2021
entrez:
7
4
2021
pubmed:
8
4
2021
medline:
21
7
2021
Statut:
ppublish
Résumé
Hydrogen sulfide (H
Identifiants
pubmed: 33826201
doi: 10.1096/fj.202002675R
doi:
Substances chimiques
Cystathionine gamma-Lyase
EC 4.4.1.1
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21511Informations de copyright
© 2021 Federation of American Societies for Experimental Biology.
Références
Jin S, Pu SX, Hou CL, et al. Cardiac H2S generation is reduced in ageing diabetic mice. Oxid Med Cell Longev. 2015;2015:758358.
Yang G, Wu L, Jiang B, et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008;322:587-590.
Chen YH, Yao WZ, Geng B, et al. Endogenous hydrogen sulfide in patients with COPD. Chest. 2005;128:3205-3211.
Hine C, Harputlugil E, Zhang Y, et al. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015;160:132-144.
Shaposhnikov M, Proshkina E, Koval L, Zemskaya N, Zhavoronkov A, Moskalev A. Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster. Aging (Albany NY). 2018;10:3260-3272.
Sen U, Sathnur PB, Kundu S, et al. Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia. Am J Physiol Cell Physiol. 2012;303:C41-C51.
Mustafa AK, Sikka G, Gazi SK, et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res. 2011;109:1259-1268.
Wang R. Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev. 2012;92:791-896.
Wang Y, Yu R, Wu L, Yang G. Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide. 2020;103:9-19.
Yang G, Cao K, Wu L, Wang R. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. J Biol Chem. 2004;279:49199-49205.
Yang G, Ju Y, Fu M, et al. Cystathionine gamma-lyase/H2S system is essential for adipogenesis and fat mass accumulation in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:165-176.
Matei IV, Ii H, Yaegaki K. H2S enhances pancreatic β-cell differentiation from human tooth under normal and glucotoxic conditions. Regen Med. 2017;12:125-141.
Leslie M. Medicine: nothing rotten about hydrogen sulfide's medical promise. Science. 2008;320:1155-1157.
Szczesny B, Módis K, Yanagi K, et al. AP39, a novel mitochondria-targeted H2S donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide. 2014;41:120-130.
Mani S, Li H, Untereiner A, et al. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation. 2013;127:2523-2534.
Paul BD, Sbodio JI, Xu R, et al. Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease. Nature. 2014;509:96-100.
Das A, Huang GX, Bonkowski MS, et al. Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging. Cell. 2018;173:74-89.e20.
Qabazard B, Stürzenbaum SR. H2S: a new approach to lifespan enhancement and healthy ageing? Handb Exp Pharmacol. 2015;230:269-287.
Nagpure BV, Bian JS. Brain, learning, and memory: role of H2S in neurodegenerative diseases. Handb Exp Pharmacol. 2015;230:193-215.
Lu F, Lu B, Zhang L, et al. Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration. J Cell Mol Med. 2020;24:9362-9377.
Bitar MS, Nader J, Al-Ali W, Al Madhoun A, Arefanian H, Al-Mulla F. Hydrogen sulfide donor NaHS improves metabolism and reduces muscle atrophy in Type 2 diabetes: implication for understanding sarcopenic pathophysiology. Oxid Med Cell Longev. 2018;2018:6825452.
Islam KN, Polhemus DJ, Donnarumma E, Brewster LP, Lefer DJ. Hydrogen sulfide levels and nuclear factor-erythroid 2-related factor 2 (NRF2) activity are attenuated in the setting of critical limb ischemia (CLI). J Am Heart Assoc. 2015;4:e001986.
Wang WJ, Cai GY, Ning YC, et al. H2S mediates the protection of dietary restriction against renal senescence in aged F344 rats. Sci Rep. 2016;6:30292.
Miller DL, Roth MB. Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007;104:20618-20622.
Shaposhnikov MV, Zemskaya NV, Koval LA, et al. Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster. Biogerontology. 2021. Online ahead of print. https://doi.org/10.1007/s10522-021-09911-4.
Lu Z, Zhao T, Tao L, et al. Cystathionine β-synthase-derived H2S correlates with successful aging in mice. Rejuvenation Res. 2019;22:513-520.
Qabazard B, Li L, Gruber J, et al. Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans. Antioxid Redox Signal. 2014;20:2621-26230.
Zivanovic J, Kouroussis E, Kohl JB, et al. Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration. Cell Metab. 2019;30:1152-1170.
Stokes E, Shuang T, Zhang Y, et al. Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells. Life Sci. 2018;213:116-125.
Ju Y, Untereiner A, Wu L, Yang G. H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells. Biochim Biophys Acta. 2015;1850:2293-2303.
Sen N. Functional and molecular insights of hydrogen sulfide signaling and protein sulfhydration. J Mol Biol. 2017;429:543-561.
Gao X, Li L, Parisien M, et al. Discovery of a redox thiol switch: implications for cellular energy metabolism. Mol Cell Proteomics. 2020;19:852-870.
Brunet A, Berger SL. Epigenetics of aging and aging-related disease. J Gerontol A Biol Sci Med Sci. 2014;69:S17-20.
Braun T, Gautel M. Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis. Nat Rev Mol Cell Biol. 2011;12:349-361.
Egerman MA, Cadena SM, Gilbert JA, et al. GDF11 increases with age and inhibits skeletal muscle regeneration. Cell Metab. 2015;22:164-174.
Byun SK, An TH, Son MJ, et al. HDAC11 inhibits myoblast differentiation through repression of myoD-dependent transcription. Mol Cells. 2017;40:667-676.
Ding J, Nie M, Liu J, et al. Trbp is required for differentiation of myoblasts and normal regeneration of skeletal muscle. PLoS ONE. 2016;11:e0155349.
Keller K. Sarcopenia. Wien Med Wochenschr. 2019;169:157-172.
Potthoff MJ, Olson EN. MEF2: a central regulator of diverse developmental programs. Development. 2007;134:4131-4140.
Liu N, Nelson BR, Bezprozvannaya S, et al. Requirement of MEF2A, C, and D for skeletal muscle regeneration. Proc Natl Acad Sci U S A. 2014;111:4109-4114.
Naidu PS, Ludolph DC, To RQ, Hinterberger TJ, Konieczny SF. Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. Mol Cell Biol. 1995;15:2707-2718.
Vellecco V, Armogida C, Bucci M. Hydrogen sulfide pathway and skeletal muscle: an introductory review. Br J Pharmacol. 2018;175:3090-3099.
Vellecco V, Martelli A, Bibli IS, et al. Anomalous K v 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2S and persulfidation in skeletal muscle. Br J Pharmacol. 2020;177:810-823.
Yang R, Jia Q, Li Y, Mehmood S. Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats. Exp Biol Med (Maywood). 2020;245:1280-1289. https://doi.org/10.1177/1535370220931038
Wetzel MD, Wenke JC. Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. J Transl Med. 2019;17:33.
Parsanathan R, Jain SK. Hydrogen sulfide regulates circadian-clock genes in C 2 C 12 myotubes and the muscle of high-fat-diet-fed mice. Arch Biochem Biophys. 2019;672:108054.
Majumder A, Singh M, Behera J, et al. Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury. Am J Physiol Cell Physiol. 2018;315:C609-C622.
Zhang Y, Wang Y, Read E, et al. Golgi stress response, H2S metabolism, and intracellular calcium homeostasis. Antioxid Redox Signal. 2020;32:583-601.
Wang R, Li K, Wang H, et al. Endogenous CSE/hydrogen sulfide system regulates the effects of glucocorticoids and insulin on muscle protein synthesis. Oxid Med Cell Longev. 2019;2019:9752698.
Parsanathan R, Jain SK. Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C 2 C 12 mouse myotubes. Free Radic Res. 2018;52:288-303.
Wang X, Zeng R, Xu H, Xu Z, Zuo B. The nuclear protein-coding gene ANKRD23 negatively regulates myoblast differentiation. Gene. 2017;629:68-75.
Yang G, Zhao K, Ju Y, et al. Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid Redox Signal. 2013;18:1906-1919.
Zhao K, Ju Y, Li S, Altaany Z, Wang R, Yang G S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair. EMBO Rep. 2014;15:792-800.
Zhao W, Zhang J, Lu Y, Wang R. The vasorelaxant effect of H2S as a novel endogenous gaseous K(ATP) channel opener. EMBO J. 2001;20:6008-6016.
Shatalin K, Shatalina E, Mironov A, Nudler E. H2S: a universal defense against antibiotics in bacteria. Science. 2011;334:986-990.
Fu M, Zhang W, Wu L, Yang G, Li H, Wang R. Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci U S A. 2012;109:2943-2948.
Guo B, Hembruff SL, Villeneuve DJ, Kirwan AF, Parissenti AM. Potent killing of paclitaxel- and doxorubicin-resistant breast cancer cells by calphostin C accompanied by cytoplasmic vacuolization. Breast Cancer Res Treat. 2003;82:125-141.
Kozhemyakina E, Cohen T, Yao T, Lassar AB. Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol Cell Biol. 2009;29:5751-5762.
Mustafa AK, Gadalla MM, Sen N, et al. H2S signals through protein S-sulfhydration. Sci Signal. 2009;2:ra72.
Mani S, Yang G, Wang R. A critical life-supporting role for cystathionine γ-lyase in the absence of dietary cysteine supply. Free Radic Biol Med. 2011;50:1280-1287.
Dröge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci. 2005;360:2355-2372.
Iciek M, Kowalczyk-Pachel D, Bilska-Wilkosz A, Kwiecień I, Górny M, Włodek L. S-sulfhydration as a cellular redox regulation. Biosci Rep. 2015;36:e00304.
Olguin HC, Olwin BB. Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal. Dev Biol. 2004;275:375-388.
Liu N, Williams AH, Maxeiner JM, et al. microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. J Clin Invest. 2012;122:2054-2065.
Baghdadi MB, Firmino J, Soni K, et al. Notch-induced miR-708 antagonizes satellite cell migration and maintains quiescence. Cell Stem Cell. 2018;23:859-868.e5.
Wang P, Wu L, Ju Y, et al. Age-dependent allergic asthma development and cystathionine gamma-Lyase deficiency. Antioxid Redox Signal. 2017;27:931-944.
Perridon BW, Leuvenink HG, Hillebrands JL, van Goor H, Bos EM. The role of hydrogen sulfide in aging and age-related pathologies. Aging (Albany NY). 2016;8:2264-2289.
Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu M. Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J Biol Chem. 2010;285:26358-26368.
McDonagh B, Sakellariou GK, Smith NT, Brownridge P, Jackson MJ. Differential cysteine labeling and global label-free proteomics reveals an altered metabolic state in skeletal muscle aging. J Proteome Res. 2014;13:5008-5021.
Rizvi SI, Maurya PK. L-cysteine influx in erythrocytes as a function of human age. Rejuvenation Res. 2008;11:661-665.
Lands LC, Grey VL, Smountas AA. Effect of supplementation with a cysteine donor on muscular performance. J Appl Physiol. 1999;87:1381-1385.
Sinha-Hikim I, Sinha-Hikim AP, Parveen M, et al. Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging. J Gerontol A Biol Sci Med Sci. 2013;68:749-759.
Longchamp A, Mirabella T, Arduini A, et al. Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production. Cell. 2018;173:117-129.e14.
Ohtsubo H, Sato Y, Suzuki T, et al. APOBEC2 negatively regulates myoblast differentiation in muscle regeneration. Int J Biochem Cell Biol. 2017;85:91-101.
Zhao K, Li H, Li S, Yang G. Regulation of cystathionine gamma-lyase/H2S system and its pathological implication. Front Biosci (Landmark Ed). 2014;19:1355-1369.
Dodou E, Xu SM, Black BL. mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo. Mech Dev. 2003;120:1021-1032.
Okamoto S, Nakamura T, Cieplak P, et al. S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Rep. 2014;8:217-228.
Yang G, Pei Y, Teng H, Cao Q, Wang R. Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells. J Biol Chem. 2011;286:26450-26460.
Yang G, Li H, Tang G, et al. Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in α5β1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells. J Mol Cell Cardiol. 2012;52:677-688.