Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology.

Animals High-Throughput Screening Assays / methods Humans Potassium / metabolism Potassium Channels, Inwardly Rectifying / metabolism Small Molecule Libraries / pharmacology
drug discovery high-throughput screening medicinal chemistry small molecules

Journal

American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225

Informations de publication

Date de publication:
01 06 2021
Historique:
pubmed: 8 4 2021
medline: 24 7 2021
entrez: 7 4 2021
Statut: ppublish

Résumé

Inward rectifying potassium (Kir) channels play important roles in both excitable and nonexcitable cells of various organ systems and could represent valuable new drug targets for cardiovascular, metabolic, immune, and neurological diseases. In nonexcitable epithelial cells of the kidney tubule, for example, Kir1.1 (

Identifiants

DOI: 10.1152/ajpcell.00548.2020 PMID: 33826405 PMC: PMC8285633
pubmed: 33826405
doi: 10.1152/ajpcell.00548.2020
pmc: PMC8285633
doi:

Substances chimiques

Potassium Channels, Inwardly Rectifying 0
Small Molecule Libraries 0
Potassium RWP5GA015D

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

C1125-C1140

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK120821
Pays : United States

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Auteurs

C David Weaver (CD)

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Department of Chemistry, Vanderbilt University, Nashville, Tennessee.
Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.

Jerod S Denton (JS)

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.
Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Next-generation inward rectifier potassium...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › Next-generation inward rectifier potassium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Next-generation inward rectifier potassium...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Potassium › Next-generation inward rectifier potassium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Next-generation inward rectifier potassium...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Bibliothèques de petites molécules › Next-generation inward rectifier potassium...