Evaluation of efficacy of intradermal injection therapy vs derma roller application for administration of QR678 Neo
QR678 Neo
androgenetic alopecia
derma roller
hair regrowth therapy
intradermal application
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
15
04
2021
received:
17
03
2021
accepted:
29
03
2021
pubmed:
8
4
2021
medline:
21
10
2021
entrez:
7
4
2021
Statut:
ppublish
Résumé
Non-surgical hair restoration is one of the most exciting and innovative fields in cosmetic surgery today. The addition of latest technique like derma roller seeks to achieve better results for delivering pharmaceutical solution for hair growth in comparison with topical administration. We aim to compare intradermal injection vs. derma roller technique for administration of QR678Neo A sum of 50 patients in the age range of 20-70 years with AGA were included and divided into 2 groups; Group A (intradermal) and Group B (derma roller). Intradermal injection of QR678Neo Significant diminution in hair fall was seen in both the groups. All the video-microscopic assessment factors were better in intradermal injection group compared to the derma roller group, but not significant. Erythema and pain were high in derma roller group in compare to intradermal. Derma roller technique is more convenient and easy to perform, especially when the availability of a trained person to carry out intradermal injection is not feasible, it gives satisfactory results. It is also beneficial in needle phobic and apprehensive patients. Though the results are more efficacious with intradermal scalp injection technique, this study established satisfactory results with derma roller technique as well.
Sections du résumé
BACKGROUND
BACKGROUND
Non-surgical hair restoration is one of the most exciting and innovative fields in cosmetic surgery today. The addition of latest technique like derma roller seeks to achieve better results for delivering pharmaceutical solution for hair growth in comparison with topical administration.
AIM
OBJECTIVE
We aim to compare intradermal injection vs. derma roller technique for administration of QR678Neo
METHOD
METHODS
A sum of 50 patients in the age range of 20-70 years with AGA were included and divided into 2 groups; Group A (intradermal) and Group B (derma roller). Intradermal injection of QR678Neo
RESULTS
RESULTS
Significant diminution in hair fall was seen in both the groups. All the video-microscopic assessment factors were better in intradermal injection group compared to the derma roller group, but not significant. Erythema and pain were high in derma roller group in compare to intradermal.
CONCLUSION
CONCLUSIONS
Derma roller technique is more convenient and easy to perform, especially when the availability of a trained person to carry out intradermal injection is not feasible, it gives satisfactory results. It is also beneficial in needle phobic and apprehensive patients. Though the results are more efficacious with intradermal scalp injection technique, this study established satisfactory results with derma roller technique as well.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3299-3307Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Ebling FJ. Hair. J Invest Dermatol. 1976;67:98-105.
Yesudian P. Human hair - an evolutionary relic? Int J Trichology. 2011;3:69.
Bernardez C, Molina-Ruiz AM, Requena L. Histologic features of alopecias-part I: non-scarring alopecias. Actas Dermosifiliogr. 2015;106:158-167.
Filbrandt R, Rufaut N, Jones L, Sinclair R. Primary cicatricial alopecia: diagnosis and treatment. CMAJ. 2013;185:1579-1585.
Qi J, Garza LA. An overview of alopecias. Cold Spring Harb Perspect Med. 2014;4(3):a013615.
Jones MC. Treatment options for androgenetic alopecia. US Pharm. 2018;43:12-16.
Yoo KH, Lee JW, Li K, Kim BJ, Kim MN. Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration. Dermatol Surg. 2010;36:618-622.
Park JH, Choi SO, Seo S, Choy YB, Prausnitz MR. A microneedle roller for transdermal drug delivery. Eur J Pharm Biopharm. 2010;76:282-289.
Prausnitz MR. Microneedles for transdermal drug delivery. Adv Drug Deliv Rev. 2004;56:581-587.
Park KY, Jang WS, Lim YY, et al. Safety evaluation of stamp type digital microneedle devices in hairless mice. Ann Dermatol. 2013;25:46-53.
Lee YB, Eun YS, Lee JH, et al. Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: a pilot study. J Dermatol. 2013;40:81-83.
Kapoor R, Shome D, Vadera S, Kumar V. QR678 &QR678 Neo hair growth formulations: A cellular toxicity & animal efficacy study. PRS global open 2020.
Kapoor R, Shome D. Intradermal injections of a hair growth factor formulation for enhancement of human hair regrowth - safety and efficacy evaluation in a first-in-man pilot clinical study. J Cosmet Laser Ther. 2018;20(6):369-379.
Kapoor R, Shome D, Doshi K, Vadera S, Patel G, Kumar V. Evaluation of efficacy of QR678®and QR678® Neo hair growth factor formulation in the treatment of persistent chemotherapy-induced alopecia caused due to cytotoxic chemotherapy-A prospective pilot study. J Cosmet Dermatol. 2020;1-10.
Kapoor R, Shome D, Vadera S, Ram MS. QR 678 & QR678 Neo Vs PRP-A randomized, comparative, prospective study. J Cosmet Dermatol. 2020;19:2877-2885.
Kapoor R, Shome D, Doshi K, Patel G, Vadera S. Evaluation of efficacy of QR 678 and QR678 neo hair growth factor formulation for the treatment of female pattern alopecia in patients with PCOS-A prospective study. J Cosmet Dermatol. 2020;00:1-10.
Gupta M, Mysore V. Classification on patterned hair loss: a review. Cutan Aesthet Surg. 2016;9:3-1.
Cranwell W, Sinclair R. Male androgenetic alopecia. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, et al, Endotext [Internet]. South Dartmouth, MA: MDText.com; 2000.
Dhurat R, Sukesh M, Avhad G, Dandale A, Pal A, Pund P. A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study. Int J Trichology. 2013;5:6.
Kaliyadan F, Nambiar A, Vijayaraghavan S. Androgenetic alopecia: An update. Indian J Dermatol Venereol Leprol. 2013;79(5):613.
Olsen EA, Weiner MS, Delong ER, Pinnell SR. Topical minoxidil in male pattern baldness. J Am Acad Dermatol. 1985;13:185-192.
Kaufman KD, Olsen EA, Whiting D, et al. Finasteride in the treatment of androgenic alopecia. J Am Acad Dermatol. 1998;39:578-589.
Jha AK, Vinay K. Androgenetic alopecia and microneedling: every needling is not microneedling. J Am Acad Dermatol. 2019;81:e43-e44.
Faghihi G, Nabavinejad S, Mokhtari F, Naeini FF, Iraji F. Microneedling in androgenetic alopecia; comparing two different depth of microneedles. J Cosmet Dermatol. 2020;20:1241-1247.
Randall VA, Thornton MJ, Hamada K, Messenger AG. Mechanism of androgen action in cultured dermal papilla cells derived from human hair follicles with varying responses to androgens in vivo. J Invest Dermatol. 1992;98:86S-91S.
Leirós GJ, Attorresi AI, Balañá ME. Hair follicle stem cell differentiation is inhibited through cross-talk between wnt/β-catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia. Br J Dermatol. 2012;166:1035-1042.
O’Toole EA, Mellerio JE. Wound healing. In: Burns TB, Cox N, Griffiths C, eds. Rook's Textbook of Dermatology (8th edn). King's College, London: Blackwell Publishing; 2010:14.1-27.
Jeong K, Lee YJ, Kim JE, Park YM, Kim BJ, Kang H. Repeated microneedle stimulation induce the enhanced expression of hair-growth-related genes. Int J Trichology. 2012;4:117.
Kim BJ, Lim YY, Kim HM, et al. Hair follicle regeneration in mice after wounding by microneedle roller. Int J Trichology. 2012;4:117.
Kumar MK, Inamadar AC, Palit A. A randomized controlled, single-observer blinded study to determine the efficacy of topical minoxidil plus microneedling versus topical minoxidil alone in the treatment of androgenetic alopecia. J Cutan Aesthet Surg. 2018;11:211-216.