Coenzyme Q
Animals
Antidotes
/ therapeutic use
Arsenic Poisoning
/ blood
Arsenites
/ toxicity
Blood Cells
/ drug effects
Brain
/ drug effects
Chelating Agents
/ therapeutic use
Drug Therapy, Combination
Glutathione
/ metabolism
Hematocrit
Kidney
/ drug effects
Liver
/ drug effects
Male
Mice
Protective Agents
/ therapeutic use
Sodium Compounds
/ toxicity
Succimer
/ therapeutic use
Ubiquinone
/ analogs & derivatives
Glutathione
Immune response
Inflammation
Organ metal damage
Ubiquinone
Journal
BMC pharmacology & toxicology
ISSN: 2050-6511
Titre abrégé: BMC Pharmacol Toxicol
Pays: England
ID NLM: 101590449
Informations de publication
Date de publication:
07 04 2021
07 04 2021
Historique:
received:
04
12
2020
accepted:
16
03
2021
entrez:
8
4
2021
pubmed:
9
4
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA). As a pharmacological intervention, DMSA is unable to chelate arsenic molecules from intracellular spaces. The consequence is continued toxicity and cell damage in the presence of DMSA. A two-pronged approach that removes extracellular arsenic, while protecting from the intracellular arsenic would provide a better pharmacotherapeutic outcome. In this study, Coenzyme Q Group one represented the control; the second group was treated with NaAsO Administration of CoQ Findings from this study demonstrate that CoQ
Sections du résumé
BACKGROUND
Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA). As a pharmacological intervention, DMSA is unable to chelate arsenic molecules from intracellular spaces. The consequence is continued toxicity and cell damage in the presence of DMSA. A two-pronged approach that removes extracellular arsenic, while protecting from the intracellular arsenic would provide a better pharmacotherapeutic outcome. In this study, Coenzyme Q
METHODS
Group one represented the control; the second group was treated with NaAsO
RESULTS
Administration of CoQ
CONCLUSIONS
Findings from this study demonstrate that CoQ
Identifiants
pubmed: 33827703
doi: 10.1186/s40360-021-00484-z
pii: 10.1186/s40360-021-00484-z
pmc: PMC8028750
doi:
Substances chimiques
Antidotes
0
Arsenites
0
Chelating Agents
0
Protective Agents
0
Sodium Compounds
0
Ubiquinone
1339-63-5
sodium arsenite
48OVY2OC72
Succimer
DX1U2629QE
coenzyme Q10
EJ27X76M46
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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